公开(公告)号：US20240376073A1

公开(公告)日：2024-11-14

申请号：US18404194

申请日：2024-01-04

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra Marie Joseph GRALL-ULSEMER ,  Xingchun HAN ,  Joel Lukas KNECHT ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Patrizio MATTEI ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D401/12 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5355 ,  A61P31/04 ,  C07C53/06 ,  C07C53/10 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/14 ,  C07D487/04

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as described herein: Frther provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20210309658A1

公开(公告)日：2021-10-07

申请号：US17331599

申请日：2021-05-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Fabian DEY ,  Yimin HU ,  Yongqiang LIU ,  Hong SHEN ,  Houguang SHI ,  Xuefei TAN ,  Shixiang YAN ,  Weixing ZHANG ,  Zhiwei ZHANG ,  Chengang ZHOU ,  Mingwei ZHOU ,  Wei ZHU

IPC: C07D471/04 ,  A61P31/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20210309657A1

公开(公告)日：2021-10-07

申请号：US17331598

申请日：2021-05-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Fabian DEY ,  Yimin HU ,  Yongqiang LIU ,  Hong SHEN ,  Houguang SHI ,  Xuefei TAN ,  Shixiang YAN ,  Weixing ZHANG ,  Zhiwei ZHANG ,  Chengang ZHOU ,  Mingwei ZHOU ,  Wei ZHU

IPC: C07D471/04 ,  C07D519/00 ,  A61P31/04

Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20230257354A1

公开(公告)日：2023-08-17

申请号：US18117966

申请日：2023-03-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D233/90 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  A61P31/04

CPC classification number: C07D233/90 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  A61P31/04

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R9 and p are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230234939A1

公开(公告)日：2023-07-27

申请号：US18114959

申请日：2023-02-27

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra Marie Joseph GRALL-ULSEMER ,  Wolfgang GUBA ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Markus RUDOLPH ,  Sébastien SCHMITT ,  Lorenz URNER ,  Yongguang WANG ,  Min WANG ,  Jianhua WANG ,  Song YANG ,  Chengang ZHOU ,  Patrizio MATTEI

IPC: C07D401/14 ,  C07D403/14 ,  A61P31/04

CPC classification number: C07D401/14 ,  C07D403/14 ,  A61P31/04

Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1-R7 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230133845A1

公开(公告)日：2023-05-04

申请号：US17865192

申请日：2022-07-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Mathis BRAENDLIN ,  Sandra Marie Joseph GRALL-ULSEMER ,  Xingchun HAN ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Sébastien SCHMITT ,  Jianhua WANG ,  Yongguang WANG ,  Min WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  A61P31/04

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20210221832A1

公开(公告)日：2021-07-22

申请号：US17213125

申请日：2021-03-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Xiao DING ,  Yongqiang LIU ,  Hong SHEN ,  Houguang SHI ,  Xuefei TAN ,  Chengang ZHOU ,  Mingwei ZHOU

IPC: C07F9/6561 ,  C07D519/00 ,  A61P31/04 ,  B01J23/44

Abstract: The present invention relates to novel compounds of formula (I) or (II), wherein R1 to R6, R11 to R17 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US20230203047A1

公开(公告)日：2023-06-29

申请号：US18070648

申请日：2022-11-29

Applicant: Hoffmann-La Roche Inc.

Inventor： Christian LERNER ,  Yongqiang LIU ,  Song YANG ,  Chengang ZHOU

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1 to X4, R1 to R5, R8 to R10, A, and L1 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230141600A1

公开(公告)日：2023-05-11

申请号：US18076274

申请日：2022-12-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Christian KRAMER ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Sébastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/20 ,  A61K9/48 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

CPC classification number: C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2009 ,  A61K9/4866 ,  A61K9/4858 ,  A61K9/485 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein:




or pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20210323981A1

公开(公告)日：2021-10-21

申请号：US17326241

申请日：2021-05-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Hong SHEN ,  Xuefei TAN ,  Chengang ZHOU ,  Mingwei ZHOU ,  Yimin HU ,  Houguang SHI ,  Fabian DEY ,  Yongqiang LIU ,  Xiao DING

IPC: C07D519/00

Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.