公开(公告)号：US20230123268A1

公开(公告)日：2023-04-20

申请号：US18062892

申请日：2022-12-07

Applicant: Hoffmann-La Roche Inc.

Inventor： Angélica BEURIER ,  Luke GREEN ,  Christian KRAMER ,  Dmitry MAZUNIN ,  Emmanuel PINARD ,  Hasane RATNI

IPC: C07D487/04 ,  C07D471/04

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and n are as defined herein, compositions including methods of making the compounds and using the compounds as ATX inhibitors.

公开(公告)号：US20230112172A1

公开(公告)日：2023-04-13

申请号：US18062896

申请日：2022-12-07

Applicant: Hoffmann-La Roche Inc.

Inventor： Virginie BROM ,  Luke GREEN ,  Christian KRAMER ,  Dmitry MAZUNIN ,  Emmanuel PINARD ,  Hasane RATNI

IPC: C07D413/04 ,  C07D403/04

Abstract: The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20240025883A1

公开(公告)日：2024-01-25

申请号：US18455029

申请日：2023-08-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Guido GALLEY ,  Luca GOBBI ,  Wolfgang GUBA ,  Dmitry MAZUNIN ,  Emmanuel PINARD ,  Antonio RICCI

IPC: C07D403/12 ,  C07D409/12 ,  C07D495/04 ,  C07D471/04 ,  C07D405/14 ,  C07D491/048 ,  C07D513/04

CPC classification number: C07D403/12 ,  C07D409/12 ,  C07D495/04 ,  C07D513/04 ,  C07D405/14 ,  C07D491/048 ,  C07D471/04

Abstract: Compounds having the general formula I




wherein R1, R2, R3, R4, X1 and X2 are as described herein, composition including the compounds and methods of using the compounds for treatment of GPR17-mediated diseases.

公开(公告)号：US20230382911A1

公开(公告)日：2023-11-30

申请号：US18361526

申请日：2023-07-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Andrew Simon BELL ,  Jérémy BESNARD ,  Anthony Richard BRADLEY ,  Luke GREEN ,  Wolfgang HAAP ,  Buelent KOCER ,  Andreas KUGLSTATTER ,  Xavier LUCAS ,  Patrizio MATTEI ,  Dmitry MAZUNIN ,  Claus RIEMER ,  Willem Paul VAN HOORN

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of formula I or II:




wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：US20230174516A1

公开(公告)日：2023-06-08

申请号：US18062644

申请日：2022-12-07

Applicant: Hoffmann-La Roche Inc.

Inventor： Angelica BEURIER ,  Michail Konstantinos BOGDOS ,  Luke GREEN ,  Christian KRAMER ,  Dmitry MAZUNIN ,  Emmanuel PINARD ,  Hasane RATNI

IPC: C07D403/06 ,  C07D491/107

CPC classification number: C07D403/06 ,  C07D491/107

Abstract: The invention provides novel compounds having the general formula (I)




wherein R1, R2, R3, R4 and R5 are as defined herein, compositions including the compounds and methods of using the compounds.