公开(公告)号：US20210009589A1

公开(公告)日：2021-01-14

申请号：US17034240

申请日：2020-09-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Jérôme HERT ,  Daniel HUNZIKER ,  Patrizio MATTEI ,  Markus RUDOLPH ,  Petra SCHMITZ ,  Patrick DI GIORGIO

IPC: C07D471/04 ,  A61K9/20 ,  A61K9/48 ,  C07D401/14 ,  C07D405/14 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20200317624A1

公开(公告)日：2020-10-08

申请号：US16793178

申请日：2020-02-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Jerome HERT ,  Daniel HUNZIKER ,  Christoph KURATLI ,  Rainer E. MARTIN ,  Patrizio MATTEI ,  Alexander Lee SATZ

IPC: C07D239/90 ,  C07D401/04 ,  C07D471/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, A1, A2, A3, n and m are as described herein.

公开(公告)号：US20200223854A1

公开(公告)日：2020-07-16

申请号：US16832553

申请日：2020-03-27

Applicant: Hoffmann-La Roche Inc.

Inventor： Patrick DI GIORGIO ,  Jerome HERT ,  Daniel HUNZIKER ,  Patrizio MATTEI ,  Markus RUDOLPH ,  Petra SCHMITZ ,  Christoph ULLMER

IPC: C07D487/04 ,  A61K31/5517 ,  A61K31/407 ,  C07D471/04 ,  A61K31/437 ,  A61P27/02

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20230234939A1

公开(公告)日：2023-07-27

申请号：US18114959

申请日：2023-02-27

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra Marie Joseph GRALL-ULSEMER ,  Wolfgang GUBA ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Markus RUDOLPH ,  Sébastien SCHMITT ,  Lorenz URNER ,  Yongguang WANG ,  Min WANG ,  Jianhua WANG ,  Song YANG ,  Chengang ZHOU ,  Patrizio MATTEI

IPC: C07D401/14 ,  C07D403/14 ,  A61P31/04

CPC classification number: C07D401/14 ,  C07D403/14 ,  A61P31/04

Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1-R7 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20200002336A1

公开(公告)日：2020-01-02

申请号：US16569459

申请日：2019-09-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Jérôme HERT ,  Daniel HUNZIKER ,  Patrizio MATTEI ,  Markus RUDOLPH ,  Petra SCHMITZ ,  Patrick DI GIORGIO

IPC: C07D471/04 ,  C07D405/14 ,  C07D498/04 ,  C07D401/14 ,  C07D519/00 ,  C07D513/04 ,  C07D495/04 ,  A61K9/20 ,  A61K9/48

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20200002297A1

公开(公告)日：2020-01-02

申请号：US16569475

申请日：2019-09-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Patrizio MATTEI ,  Jérôme HERT ,  Daniel HUNZIKER ,  Markus RUDOLPH ,  Petra SCHMITZ ,  Patrick DI GIORGIO ,  Justin GOMME

IPC: C07D257/04 ,  C07D405/14 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D401/10 ,  C07D403/10 ,  C07D417/14 ,  C07D401/06 ,  C07D409/14

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20240376073A1

公开(公告)日：2024-11-14

申请号：US18404194

申请日：2024-01-04

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra Marie Joseph GRALL-ULSEMER ,  Xingchun HAN ,  Joel Lukas KNECHT ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Patrizio MATTEI ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D401/12 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5355 ,  A61P31/04 ,  C07C53/06 ,  C07C53/10 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/14 ,  C07D487/04

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as described herein: Frther provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20210015792A1

公开(公告)日：2021-01-21

申请号：US17034323

申请日：2020-09-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Patrizio MATTEI ,  Daniel HUNZIKER ,  Patrick DI GIORGIO ,  Jerome HERT ,  Markus RUDOLPH ,  Lisha WANG

IPC: A61K31/407 ,  C07D209/56 ,  C07D487/04

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20200339570A1

公开(公告)日：2020-10-29

申请号：US16818409

申请日：2020-03-13

Applicant: Hoffmann-La Roche Inc.

Inventor： Jerome HERT ,  Daniel HUNZIKER ,  Patrizio MATTEI ,  Harald MAUSER ,  Guozhi TANG ,  Lisha WANG

IPC: C07D471/04 ,  C07D519/00 ,  C07D413/12 ,  C07D403/12 ,  C07D487/04

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20150099734A1

公开(公告)日：2015-04-09

申请号：US14569564

申请日：2014-12-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Daniel HUNZIKER ,  Patrizio MATTEI ,  Harald MAUSER ,  Marco PRUNOTTO ,  Christoph ULLMER

IPC: C07D519/00 ,  C07D487/10 ,  C07D205/12 ,  C07D471/10 ,  C07D403/12

CPC classification number: C07D471/10 ,  C07D205/12 ,  C07D249/18 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/12 ,  C07D487/10 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y and W are as described herein, compositions including the compounds and methods of using the compounds.

Abstract translation: 本发明提供具有通式（I）的新化合物，其中R 1，R 2，Y和W如本文所述，包括该化合物的组合物和使用该化合物的方法。