公开(公告)号：US20230219953A1

公开(公告)日：2023-07-13

申请号：US18068360

申请日：2022-12-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Andrew Simon Bell ,  Jérémy Besnard ,  Anthony Richard Bradley ,  Luke Green ,  Wolfgang Haap ,  Buelent Kocer ,  Andreas Kuglstatter ,  Xavier Lucas ,  Patrizio Mattei ,  Dmitry Mazunin ,  Claus Riemer ,  Willem Paul Van Hoorn

IPC: C07D471/04 ,  C07D231/56 ,  C07D209/08

CPC classification number: C07D471/04 ,  C07D231/56 ,  C07D209/08

Abstract: The present invention provides compounds of formula I




wherein X1, X2, X3, X4, R1, R1a, R1b, R2′, R2″, R3′, R3″, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：US20240400556A1

公开(公告)日：2024-12-05

申请号：US18654989

申请日：2024-05-03

Applicant: Hoffmann-La Roche Inc.

Inventor： Andrew Simon Bell ,  Jérémy Besnard ,  Anthony Richard Bradley ,  Luke Green ,  Wolfgang Haap ,  Buelent Kocer ,  Andreas Kuglstatter ,  Xavier Lucas ,  Patrizio Mattei ,  Dmitry Mazunin ,  Hasane Ratni ,  Claus Riemer ,  Willem Paul Van Hoorn

IPC: C07D471/04 ,  C07D239/95 ,  C07D401/04 ,  C07D405/04 ,  C07D519/00

Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：US20230227449A1

公开(公告)日：2023-07-20

申请号：US18068407

申请日：2022-12-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Andrew Simon Bell ,  Jérémy Besnard ,  Anthony Richard Bradley ,  Luke Green ,  Wolfgang Haap ,  Buelent Kocer ,  Andreas Kuglstatter ,  Xavier Lucas ,  Patrizio Mattei ,  Dmitry Mazunin ,  Hasane Ratni ,  Claus Riemer ,  Willem Paul Van Hoorn

IPC: C07D471/04 ,  C07D405/04 ,  C07D519/00 ,  C07D401/04 ,  C07D239/95

CPC classification number: C07D471/04 ,  C07D405/04 ,  C07D519/00 ,  C07D401/04 ,  C07D239/95

Abstract: The present invention provides compounds of formula I or II:




wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.