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公开(公告)号：US20230219953A1
公开(公告)日：2023-07-13
申请号：US18068360
申请日：2022-12-19
发明人： Andrew Simon Bell , Jérémy Besnard , Anthony Richard Bradley , Luke Green , Wolfgang Haap , Buelent Kocer , Andreas Kuglstatter , Xavier Lucas , Patrizio Mattei , Dmitry Mazunin , Claus Riemer , Willem Paul Van Hoorn
IPC分类号： C07D471/04 , C07D231/56 , C07D209/08
CPC分类号： C07D471/04 , C07D231/56 , C07D209/08
摘要： The present invention provides compounds of formula I
wherein X1, X2, X3, X4, R1, R1a, R1b, R2′, R2″, R3′, R3″, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.-
公开(公告)号：US09758530B2
公开(公告)日：2017-09-12
申请号：US14991786
申请日：2016-01-08
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： A61K31/506 , C07D498/18 , C07D498/08 , C07D491/18 , C07D453/06 , C07D471/08 , C07D513/08 , C07D417/14 , C07D487/08 , C07D491/08 , C07D498/20
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09540345B2
公开(公告)日：2017-01-10
申请号：US14766905
申请日：2014-03-03
发明人： Steven Joseph Berthel , Zhi Chen , Feng Chi , Elbert Chin , David Shawn Erickson , Stephen Deems Gabriel , Buelent Kocer , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert
IPC分类号： C07D401/12 , C07D403/12 , C07D487/10 , C07D471/04 , C07D409/12 , C07D249/14 , A61K31/4196 , A61K31/437 , A61K31/496 , A61K31/501 , A61K31/4439 , A61K31/506 , A61K38/21 , A61K45/06
CPC分类号： C07D401/12 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/501 , A61K31/506 , A61K38/21 , A61K45/06 , C07D249/14 , C07D403/12 , C07D409/12 , C07D471/04 , C07D487/10
摘要： The present invention discloses compounds of Formula (I): wherein the variables in Formula (I) are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula (I) in the prevention or treatment of HCV infection.
摘要翻译： 本发明公开了式（I）的化合物：其中式（I）中的变量如本文所述定义。 还公开了含有这些化合物的药物组合物和使用式（I）化合物在预防或治疗HCV感染中的方法。
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公开(公告)号：US20230227449A1
公开(公告)日：2023-07-20
申请号：US18068407
申请日：2022-12-19
发明人： Andrew Simon Bell , Jérémy Besnard , Anthony Richard Bradley , Luke Green , Wolfgang Haap , Buelent Kocer , Andreas Kuglstatter , Xavier Lucas , Patrizio Mattei , Dmitry Mazunin , Hasane Ratni , Claus Riemer , Willem Paul Van Hoorn
IPC分类号： C07D471/04 , C07D405/04 , C07D519/00 , C07D401/04 , C07D239/95
CPC分类号： C07D471/04 , C07D405/04 , C07D519/00 , C07D401/04 , C07D239/95
摘要： The present invention provides compounds of formula I or II:
wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.-
公开(公告)号：US10435407B2
公开(公告)日：2019-10-08
申请号：US16266782
申请日：2019-02-04
发明人： Bernd Buettelmann , Buelent Kocer , Bernd Kuhn , Marco Prunotto , Hans Richter , Martin Ritter , Markus Rudolph , Alexander Lee Satz
IPC分类号： C07D471/10 , A61P35/00 , A61P13/12 , A61P37/06 , A61P9/00 , A61P1/16 , C07D519/00
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
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6.发明授权6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection 有权6-桥连杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染公开(公告)号：US09266904B2
公开(公告)日：2016-02-23
申请号：US14279716
申请日：2014-05-16
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： A61K31/506 , C07D498/08 , C07D417/14 , C07D498/18 , C07D491/08 , C07D487/08 , C07D513/08 , C07D498/20 , C07D453/06 , C07D471/08 , C07D491/18
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。
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![Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors](/abs-image/US/2023/03/21/US11608347B2/abs.jpg.150x150.jpg)
公开(公告)号：US11608347B2
公开(公告)日：2023-03-21
申请号：US16922427
申请日：2020-07-07
发明人： Ann Petersen , Joerg Benz , Uwe Grether , Benoit Hornsperger , Buelent Kocer , Bernd Kuhn , Hans Richter , Satoshi Tsuchiya , Yangcheng Qiu , Rui Chen
IPC分类号： C07D471/04 , C07D519/00
摘要： The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20190071444A1
公开(公告)日：2019-03-07
申请号：US16057436
申请日：2018-08-07
发明人： Bernd Buettelmann , Buelent Kocer , Bernd Kuhn , Marco Prunotto , Hans Richter , Martin Ritter
IPC分类号： C07D471/10 , C07D519/00 , C07D487/10
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
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公开(公告)号：US09693997B2
公开(公告)日：2017-07-04
申请号：US14768915
申请日：2014-03-03
发明人： Joseph Anthony Bilotta , Zhi Chen , Feng Chi , Elbert Chin , Qingjie Ding , Shawn David Erickson , Stephen Deems Gabriel , Nan Jiang , Buelent Kocer , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert , Jing Zhang , Qiang Zhang
IPC分类号： C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D491/107 , C07D495/04 , A61K31/4196 , A61K31/454 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D411/12 , C07D413/12
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D491/107 , C07D495/04
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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10.发明申请NOVEL 6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权用于治疗和预防乙型肝炎病毒感染的新型6-氨基酸异丙肾上腺素公开(公告)号：US20160237078A9
公开(公告)日：2016-08-18
申请号：US14022519
申请日：2013-09-10
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Xianfeng Lin , Haixia Liu , Alexander V Mayweg , Zongxing Qiu , Hong Shen , Guozhi Tang , Lisha Wang , Guolong Wu , Shixiang Yan , Weixing Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D417/14 , A61K31/5377 , A61K31/541 , A61K31/506
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3，R 4和A如本文所述，包括该化合物的组合物和使用该化合物的方法。
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