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公开(公告)号：US20180326011A1
公开(公告)日：2018-11-15
申请号：US15943264
申请日：2018-04-02
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Stefan Seeber , Pablo Umana , Inja Waldhauer
CPC分类号： A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61P35/00 , C07K14/55 , C07K16/2818 , C07K2317/73 , C07K2319/74
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US11413331B2
公开(公告)日：2022-08-16
申请号：US15943237
申请日：2018-04-02
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Valeria G. Nicolini , Stefan Seeber , Pablo Umana , Inja Waldhauer
IPC分类号： A61K38/20 , A61K39/395 , C07K14/55 , C07K16/28 , A61K47/68 , A61P35/00 , A61K39/00 , A61K38/00
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20230134606A1
公开(公告)日：2023-05-04
申请号：US17810041
申请日：2022-06-30
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Valeria G. Nicolini , Stefan Seeber , Pablo Umana , Inja Waldhauer
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US11591397B2
公开(公告)日：2023-02-28
申请号：US17474980
申请日：2021-09-14
发明人： Anne Freimoser-Grundschober , Thomas Hofer , Ralf Hosse , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña , Inja Waldhauer , Wolfgang Richter , Alexander Knaupp , Halina Trochanowska
摘要： The present invention generally relates to antibodies that bind to CD3, including multi specific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20220010014A1
公开(公告)日：2022-01-13
申请号：US17350111
申请日：2021-06-17
发明人： Anne Freimoser-Grundschober , Maria Valeria Gonzalez Nicolini , Ralf Hosse , Alexander Knaupp , Ekkehard Moessner , Wolfgang Richter , Halina Trochanowska , Pablo Umaña , Christian Klein , Inja Waldhauer
摘要： The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20230071733A1
公开(公告)日：2023-03-09
申请号：US17834096
申请日：2022-06-07
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Stefan Seeber , Pablo Umana , Inja Waldhauer
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20180326010A1
公开(公告)日：2018-11-15
申请号：US15943237
申请日：2018-04-02
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Valeria G. Nicolini , Stefan Seeber , Pablo Umana , Inja Waldhauer
CPC分类号： A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6891 , A61K2039/505 , A61P35/00 , C07K14/55 , C07K16/2818 , C07K2317/73 , C07K2319/74
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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