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![SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF](/abs-image/US/2016/09/29/US20160280712A1/abs.jpg.150x150.jpg)
1.发明申请SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF 审中-公开反式-8-氯代-5-甲基-1- [4-（吡啶-2-基） - 苄氧基] -5,6-二氢-4H-2,3,5,10B-四氮杂 - 苯并[E] 其结构和结构形式公开(公告)号：US20160280712A1
公开(公告)日：2016-09-29
申请号：US15172542
申请日：2016-06-03
发明人： Benno Rothenhaeusler , Rene Trussardi , Fabienne Hoffmann-Emery , Urs Schwitter , Jean-Michel Adam , Olaf Grassmann , Thomas Hartung , Frederic Ran , Ralph Diodone , Christophe Pfleger , Bjorn Bartels
IPC分类号： C07D487/04 , C07D243/14
CPC分类号： C07D487/04 , C07B2200/13 , C07D243/14
摘要： The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
摘要翻译： 本发明提供了制备取代的1- [4-（吡啶-2-基氧基） - 环己基] -5,6-二氢-4H-2,3,5,10b-四氮杂 - 苯并[e]薁的方法。 还公开了可用作本发明方法中的中间体的化合物。
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![SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF](/abs-image/US/2021/09/16/US20210284648A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210284648A1
公开(公告)日：2021-09-16
申请号：US17337547
申请日：2021-06-03
发明人： Benno Rothenhaeusler , Rene Trussardi , Fabienne Hoffmann-Emery , Urs Schwitter , Jean-Michel Adam , Olaf Grassmann , Thomas Hartung , Frederic Ran , Ralph Diodone , Christophe Pfleger , Bjorn Bartels
IPC分类号： C07D487/04 , C07D243/14
摘要： The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
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![Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof](/abs-image/US/2019/04/02/US10246460B2/abs.jpg.150x150.jpg)
公开(公告)号：US10246460B2
公开(公告)日：2019-04-02
申请号：US15172542
申请日：2016-06-03
发明人： Benno Rothenhaeusler , Rene Trussardi , Fabienne Hoffmann-Emery , Urs Schwitter , Jean-Michel Adam , Olaf Grassmann , Thomas Hartung , Frederic Ran , Ralph Diodone , Christophe Pfleger , Bjorn Bartels
IPC分类号： C07D487/04 , C07D243/14
摘要： The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
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公开(公告)号：US10227308B2
公开(公告)日：2019-03-12
申请号：US15443894
申请日：2017-02-27
发明人： Simon M. Ametamey , Juergen Fingerle , Luca Gobbi , Uwe Grether , Ahmed Haider , Thomas Hartung , Linjing Mu , Leo Nicholls , Mark Rogers-Evans , Christoph Ullmer
IPC分类号： C07D231/40 , G01N33/566 , A61K51/04 , C07B59/00 , G01N33/60 , G01N33/94
摘要： The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.
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![Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crytalline forms thereof](/abs-image/US/2021/06/22/US11040977B2/abs.jpg.150x150.jpg)
公开(公告)号：US11040977B2
公开(公告)日：2021-06-22
申请号：US16291887
申请日：2019-03-04
发明人： Benno Rothenhaeusler , Rene Trussardi , Fabienne Hoffmann-Emery , Urs Schwitter , Jean-Michel Adam , Olaf Grassmann , Thomas Hartung , Frederic Ran , Ralph Diodone , Christophe Pfleger , Bjorn Bartels
IPC分类号： C07D487/04 , C07D243/14
摘要： The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
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![SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF](/abs-image/US/2019/06/27/US20190194210A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190194210A1
公开(公告)日：2019-06-27
申请号：US16291887
申请日：2019-03-04
发明人： Benno Rothenhaeusler , Rene Trussardi , Fabienne Hoffmann-Emery , Urs Schwitter , Jean-Michel Adam , Olaf Grassmann , Thomas Hartung , Frederic Ran , Ralph Diodone , Christophe Pfleger , Bjorn Bartels
IPC分类号： C07D487/04 , C07D243/14
CPC分类号： C07D487/04 , C07B2200/13 , C07D243/14
摘要： The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
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公开(公告)号：US20170166534A1
公开(公告)日：2017-06-15
申请号：US15443894
申请日：2017-02-27
发明人： Simon M. Ametamey , Juergen Fingerle , Luca Gobbi , Uwe Grether , Ahmed Haider , Thomas Hartung , Linjing Mu , Leo Nicholls , Mark Rogers-Evans , Christoph Ullmer
IPC分类号： C07D231/40 , G01N33/566 , A61K51/04
CPC分类号： C07D231/40 , A61K51/0453 , C07B59/002 , G01N33/566 , G01N33/60 , G01N33/948 , G01N2333/705 , G01N2333/726 , G01N2500/20 , G01N2800/00
摘要： The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.
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