-
公开(公告)号：US11911394B2
公开(公告)日：2024-02-27
申请号：US17560501
申请日：2021-12-23
发明人： Takeshi Noshi , Takahiro Noda , Ryu Yoshida , Takao Shishido , Kaoru Baba , Aeron C. Hurt , Leo Yi Yang Lee , Steffen Wildum , Klaus Kuhlbusch , Barry Clinch , Jan Michal Nebesky , Annabelle Lemenuel , Wendy S. Barclay , Jean-Eric Charoin , Yoshinori Ando
IPC分类号： C07D498/14 , A61K31/5383 , A61P31/16
CPC分类号： A61K31/5383
摘要： The present invention relates to a method for preventing transmission of influenza, wherein said method comprises administering an effective amount of a compound to a patient having an influenza virus infection, herein referred to as “index patient”, wherein the compound has one of the formulae (I) and (II), or its pharmaceutically acceptable salt. The compound to be used in the present invention reduces infectivity of the influenza virus of the index patient, and therefore, reduces the risk of the index patient to trigger an influenza epidemic or an influenza pandemic as compared to a control patient. Therefore, one aspect of the present invention relates to a method for preventing an influenza epidemic or an influenza pandemic, wherein the method comprises administering an effective amount of a compound to patients having an influenza virus infection (index patients), wherein the compound is administered to at least 10% of all influenza infected persons of a city's or country's population, and wherein the compound has one of the formulae (I) and (II), or is a pharmaceutically acceptable salt thereof.
-
公开(公告)号：US20180250301A1
公开(公告)日：2018-09-06
申请号：US15970128
申请日：2018-05-03
发明人： Lu Gao , Isabel Najera , Hong Shen , Fang Shen , Liping Shi , Steffen Wildum , Guang Yang
IPC分类号： A61K31/506 , A61K31/5377 , A61P31/12
CPC分类号： A61K31/506 , A61K31/5377 , A61K38/212 , A61K2300/00 , A61P31/12
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and an interferon for use in the treatment of hepatitis B virus infections.
-
公开(公告)号：US20200276198A1
公开(公告)日：2020-09-03
申请号：US16825997
申请日：2020-03-20
发明人： Lu Gao , Isabel Najera , Hong Shen , Fang Shen , Liping Shi , Steffen Wildum , Guang Yang
IPC分类号： A61K31/506 , A61K38/21 , A61P31/12 , A61K31/5377
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and an interferon for use in the treatment of hepatitis B virus infections.
-
公开(公告)号：US20190275052A1
公开(公告)日：2019-09-12
申请号：US16282481
申请日：2019-02-22
发明人： Isabel Najera , Steffen Wildum
IPC分类号： A61K31/5377 , A61K31/522 , A61P31/20 , A61K31/506 , A61K31/675 , A61K31/7072 , A61K31/683
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and a nucleoside or nucleotide analogue for use in the treatment or prophylaxis of chronic hepatitis B patient.
-
公开(公告)号：US10596173B2
公开(公告)日：2020-03-24
申请号：US15970128
申请日：2018-05-03
发明人： Lu Gao , Isabel Najera , Hong Shen , Fang Shen , Liping Shi , Steffen Wildum , Guang Yang
IPC分类号： A61K31/506 , A61K38/21 , A61P31/12 , A61K31/5377
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and an interferon for use in the treatment of hepatitis B virus infections.
-
-
-
-
搜索结果
5 条记录 (耗时 0.02 秒)
