公开(公告)号：US06831182B2

公开(公告)日：2004-12-14

申请号：US10433424

申请日：2003-06-04

申请人： Holger Borchert ,  Stephan Schlitter ,  Rolf-Hartmuth Fischer ,  Markus Rösch ,  Frank Stein ,  Ralf-Thomas Rahn ,  Alexander Weck ,  Gerd Kaibel

发明人： Holger Borchert ,  Stephan Schlitter ,  Rolf-Hartmuth Fischer ,  Markus Rösch ,  Frank Stein ,  Ralf-Thomas Rahn ,  Alexander Weck ,  Gerd Kaibel

IPC分类号： C07D30708

CPC分类号： C07D307/08

摘要： The present invention relates to a process for the gas-phase hydrogenation of C4-dicarboxylic acids and/or their derivatives over a catalyst based on copper oxide to give substituted or unsubstituted &ggr;-butyrolactone and/or tetrahydrofuran, which comprises, which a first reaction zone in which the C4-dicarboxylic acid and/or its derivatives is/are reacted to give a mixture comprising a substituted or unsubstituted &ggr;-butyrolactone as main product and a subsequent second reaction zone in which the substituted or unsubstituted &ggr;-butyrolactone present in the mixture from the first hydrogenation step is reacted at a temperature lower than the temperature in the first hydrogenation step to give substituted or unsubstituted tetrahydrofuran.

公开(公告)号：US07217679B2

公开(公告)日：2007-05-15

申请号：US10433008

申请日：2001-12-07

申请人： Holger Borchert ,  Stephan Schlitter ,  Rolf-Hartmuth Fischer ,  Markus Rösch ,  Frank Stein ,  Ralf-Thomas Rahn ,  Alexander Weck

发明人： Holger Borchert ,  Stephan Schlitter ,  Rolf-Hartmuth Fischer ,  Markus Rösch ,  Frank Stein ,  Ralf-Thomas Rahn ,  Alexander Weck

IPC分类号： B01J37/02

CPC分类号： C07D307/33 ,  B01J23/72 ,  B01J23/76 ,  B01J23/80 ,  B01J23/8926 ,  B01J37/0215 ,  B01J37/0223 ,  C07D307/08 ,  C07D315/00

摘要： A catalyst for the hydrogenation of C4-dicarboxylic acids and/or their derivatives, preferably maleic anhydride, in the gas phase comprises from 5 to 100% by weight, preferably from 40 to 90% by weight, of copper oxide and from 0 to 95% by weight, preferably from 10 to 60% by weight, of one or more metals or compounds thereof selected from the group consisting of Al, Si, Zn, Pd, La, Ce, the elements of groups III A to VIII A and groups I A and II A as active composition applied in the form of a thin layer to an inert support material.

摘要翻译： 在气相中用于氢化C 4 - 二羧酸和/或其衍生物，优选马来酸酐的催化剂包含5至100重量％，优选40至90重量％ 的氧化铜和0至95重量％，优选10至60重量％的一种或多种选自Al，Si，Zn，Pd，La，Ce的金属或其化合物，其元素为 作为活性组合物，将IIIA至VIIIA族和IAA和IIA族作为以薄层形式施用于惰性载体材料的活性组合物。

公开(公告)号：US06730800B2

公开(公告)日：2004-05-04

申请号：US10433425

申请日：2003-06-04

申请人： Rolf-Hartmuth Fischer ,  Frank Stein ,  Rolf Pinkos ,  Michael Hesse ,  Michael Jolyon Sprague ,  Markus Rösch ,  Holger Borchert ,  Stephan Schlitter ,  Ralf-Thomas Rahn ,  Alexander Weck

发明人： Rolf-Hartmuth Fischer ,  Frank Stein ,  Rolf Pinkos ,  Michael Hesse ,  Michael Jolyon Sprague ,  Markus Rösch ,  Holger Borchert ,  Stephan Schlitter ,  Ralf-Thomas Rahn ,  Alexander Weck

IPC分类号： C07D33102

CPC分类号： B01J23/72 ,  B01J23/80 ,  C07D307/08

摘要： Unsubstituted or alkyl-substituted THF is obtained by catalytic hydrogenation in the gas phase of C4-dicarboxylic acids and/or their derivatives using a catalyst comprising 20% by weight, preferably >30% by weight, in particular from 35 to 90% by weight, of an oxidic support having acid centers, at a hot spot temperature of from 240 to 310° C., preferably from 240 to 280° C., and a WHSV over the catalyst of from 0.01 to 1.0, preferably from 0.02 to 1, in particular from 0.05 to 0.5, kg of starting material/l of catalyst x hour.

摘要翻译： 未取代或烷基取代的THF通过使用包含<80重量％，优选<70重量％，特别是10至65重量％的催化剂在C4-二羧酸和/或其衍生物的气相中通过催化氢化获得， 重量的CuO和> 20重量％，优选> 30重量％，特别是35至90重量％的具有酸中心的氧化载体，在热点温度为240-310℃， 优选为240〜280℃，催化剂上的WHSV为0.01〜1.0，优选为0.02〜1，特别优选为0.05〜0.5kg的原料/ l催化剂x小时。

公开(公告)号：US06958404B2

公开(公告)日：2005-10-25

申请号：US10450114

申请日：2001-12-07

申请人： Holger Borchert ,  Stephan Schlitter ,  Michael Hesse ,  Frank Stein ,  Rolf-Hartmuth Fischer ,  Ralf-Thomas Rahn ,  Alexander Weck ,  Markus Rösch

发明人： Holger Borchert ,  Stephan Schlitter ,  Michael Hesse ,  Frank Stein ,  Rolf-Hartmuth Fischer ,  Ralf-Thomas Rahn ,  Alexander Weck ,  Markus Rösch

IPC分类号： C07B61/00 ,  C07C51/36 ,  C07C55/10 ,  C07D307/08 ,  C07D307/33 ,  C07D307/58 ,  C07D307/60

CPC分类号： C07D307/33 ,  C07D307/08

摘要： C4-dicarboxylic acids or derivatives thereof are hydrogenated in the gas phase in a fluidized-bed reactor. It is possible to use catalyst compositions known per se.

摘要翻译： C 4 N 4 - 二羧酸或其衍生物在气相中在流化床反应器中氢化。 可以使用本身已知的催化剂组合物。

公开(公告)号：US06888011B2

公开(公告)日：2005-05-03

申请号：US10433012

申请日：2001-12-07

申请人： Holger Borchert ,  Stephan Schlitter ,  Markus Rösch ,  Rolf-Hartmuth Fischer ,  Ralf-Thomas Rahn ,  Alexander Weck

发明人： Holger Borchert ,  Stephan Schlitter ,  Markus Rösch ,  Rolf-Hartmuth Fischer ,  Ralf-Thomas Rahn ,  Alexander Weck

IPC分类号： B01J23/72 ,  B01J23/76 ,  B01J23/80 ,  B01J35/10 ,  B01J37/00 ,  B01J37/03 ,  C07B61/00 ,  C07D307/08 ,  C07D307/33 ,  C07D315/00

CPC分类号： C07D307/33 ,  B01J23/72 ,  B01J23/76 ,  B01J23/80 ,  B01J35/1061 ,  B01J35/1066 ,  B01J35/108 ,  B01J37/0018 ,  B01J37/03 ,  C07D307/08 ,  C07D315/00

摘要： A hydrogenation catalyst which is suitable, in particular, for the hydrogenation of maleic anhydride and its derivatives to THF or its derivatives comprises copper oxide and at least one further metal or compound thereof, preferably an oxide, selected from the group consisting of Al, Si, Zn, La, Ce, the elements of groups IIIA to VIIIA and the elements of groups IA and IIA and having a pore volume of ≧0.01 ml/g for pore diameters of >50 nm and a ratio of the pore volume of macropores having a diameter of >50 nm to the total pore volume for pores having a diameter of >4 nm of >10%.

摘要翻译： 特别适用于马来酸酐及其衍生物氢化成THF或其衍生物的氢化催化剂包含氧化铜和至少一种其它金属或其化合物，优选选自Al，Si ，Zn，La，Ce，IIIA至VIIIA族的元素和IA和IIA族的元素，孔径> 50nm的细孔容积> 0.01ml / g，孔的孔体积比 具有> 50nm的直径> 50nm的直径> 10nm的孔的总孔体积。

公开(公告)号：US06921830B2

公开(公告)日：2005-07-26

申请号：US10475219

申请日：2002-04-22

申请人： Ralf-Thomas Rahn ,  Alexander Weck ,  Gerd Kaibel

发明人： Ralf-Thomas Rahn ,  Alexander Weck ,  Gerd Kaibel

IPC分类号： C07D307/60 ,  C07C51/215 ,  C07C51/44 ,  C07C51/573 ,  C07C57/145 ,  C07C57/15 ,  C07D307/36

CPC分类号： C07C51/215 ,  C07C51/573 ,  C07C57/145

摘要： In a process for purifying an organic solvent for the absorption of maleic anhydride from a gaseous mixture, in which the maleic anhydride is separated off from the solvent, a substream is taken from the solvent stream, this substream is distilled and returned to the solvent circuit, the proposed improvement comprises separating off a low-boiling fraction and a high-boiling fraction from the fraction consisting essentially of purified solvent and feeding the fraction consisting essentially of purified solvent back into the solvent stream.

摘要翻译： 在从溶剂中分离马来酸酐的气体混合物中纯化用于吸收马来酸酐的有机溶剂的方法中，从溶剂流中取出一个子流，蒸馏该子流并返回溶剂回路 所提出的改进包括从基本上由纯化溶剂组成的馏分中分离低沸点馏分和高沸点馏分，并将基本上由纯化溶剂组成的馏分反馈回溶剂流中。

公开(公告)号：US06846389B2

公开(公告)日：2005-01-25

申请号：US10258938

申请日：2001-05-03

申请人： Gerd Kaibel ,  Alexander Weck ,  Ralf-Thomas Rahn

发明人： Gerd Kaibel ,  Alexander Weck ,  Ralf-Thomas Rahn

IPC分类号： B01D3/14 ,  B01D3/26 ,  C07C27/28 ,  C07C29/80 ,  C07C31/20 ,  C07D307/08 ,  C07D307/33 ,  B01D3/42

CPC分类号： C07D307/33 ,  B01D3/14 ,  B01D3/141 ,  B01D3/146 ,  C07C29/80 ,  C07D307/08 ,  Y10S203/09 ,  Y10S203/20 ,  C07C31/207

摘要： In a process for the continuous fractional distillation of mixtures comprising tetrahydrofuran, γ-butyrolactone and/or 1,4-butanediol to give at least three fractions, the fractionation is carried out in an assembly of distillation columns comprising at least one dividing wall column or at least one assembly of thermally coupled conventional distillation columns.

摘要翻译： 在包括四氢呋喃，γ-丁内酯和/或1,4-丁二醇的混合物的连续分馏的方法中，得到至少三个级分，分馏在包括至少一个分隔壁塔或 至少一个热偶联常规蒸馏塔的组件。

公开(公告)号：US06054628A

公开(公告)日：2000-04-25

申请号：US955076

申请日：1997-10-21

申请人： Manfred Stroezel ,  Udo Rheude ,  Ralf-Thomas Rahn ,  Gerd Kaibel

发明人： Manfred Stroezel ,  Udo Rheude ,  Ralf-Thomas Rahn ,  Gerd Kaibel

IPC分类号： C07B49/00 ,  C07C29/124 ,  C07C29/40 ,  C07C31/00 ,  C07C33/02 ,  C07C35/18

CPC分类号： C07C29/40

摘要： In a process for carrying out an exothermal reaction, selected from the addition reaction of organomagnesium halide compounds to carbonyl compounds and the ensuing hydrolysis of the addition product, a considerable fraction of the heat liberated during the reaction is removed by evaporation of the solvent.

摘要翻译： 在进行放热反应的方法中，选自有机卤化镁化合物与羰基化合物的加成反应以及随后的加成产物的水解，通过蒸发溶剂除去反应期间释放出的相当大部分的热量。

公开(公告)号：US06433192B1

公开(公告)日：2002-08-13

申请号：US09673847

申请日：2001-06-04

申请人： Rolf Fischer ,  Gerd Kaibel ,  Rolf Pinkos ,  Ralf-Thomas Rahn

发明人： Rolf Fischer ,  Gerd Kaibel ,  Rolf Pinkos ,  Ralf-Thomas Rahn

IPC分类号： C07D30702

CPC分类号： C07D315/00 ,  C07C29/149 ,  C07D307/08 ,  C07C31/207

摘要： In a process for preparing 1,4-butanediol, tetrahydrofuran and &ggr;-butyrolactone by oxidation of butane to give a product stream comprising maleic anhydride, absorption of maleic anhydride from the product stream using a high-boiling alcohol to give a liquid absorption product comprising monoesters and diesters of maleic acid and also high-boiling alcohol, after-esterification of the liquid absorption product and subsequent hydrogenation of the after-esterified product in the liquid phase, the high-boiling alcohol is a polyhydric alcohol having a boiling point at atmospheric pressure of above 233° C. and the after-esterified product has an acid number of less than 30 mg KOH/g and a water content of less than 1% by weight.

摘要翻译： 在通过丁烷氧化制备1,4-丁二醇，四氢呋喃和γ-丁内酯以产生包含马来酸酐的产物流的方法中，使用高沸点醇从产物流中吸收马来酸酐，得到液体吸收产物，其包含 马来酸的单酯和二酯以及高沸点醇，液体吸收产物的酯化和后期酯化产物在液相中的氢化后，高沸点醇是沸点在大气压下的多元醇 高于233℃的压力，后酯化产物的酸值小于30mg KOH / g，水含量小于1重量％。

公开(公告)号：US06350924B1

公开(公告)日：2002-02-26

申请号：US09673134

申请日：2000-10-11

申请人： Rolf Fischer ,  Gerd Kaibel ,  Rolf Pinkos ,  Ralf-Thomas Rahn

发明人： Rolf Fischer ,  Gerd Kaibel ,  Rolf Pinkos ,  Ralf-Thomas Rahn

IPC分类号： C07C2700

CPC分类号： C07D315/00 ,  C07C29/177 ,  C07D307/08 ,  C07C31/207

摘要： A process for preparing 1,4-butanediol and, if desired, &ggr;-butyrolactone and THF by oxidizing butane or benzene to form a product stream including maleic anhydride, absorbing maleic anhydride from the product stream with a high-boiling inert solvent in an absorption stage to give a liquid absorption product, esterifying the liquid absorption product with a C1-C5 esterifying alcohol in an esterification stage to form an esterification product comprising the corresponding diester and high-boiling inert solvent, then hydrogenating the esterification product to give a hydrogenation product which comprises the products of value, 1,4-butanediol and, if desired, &ggr;-butyrolactone and tetrahydrofuran and the esterifying alcohol and which is separated by distillation into the products of value and the esterifying alcohol, and recycling the esterifying alcohol to the esterification zone, which comprises separating the esterification product into the diester and the inert solvent by distillation under reduced pressure prior to the hydrogenation, recycling the inert solvent to the absorption stage, and hydrogenating the diester in the liquid phase over a fixed-bed catalyst.

摘要翻译： 通过氧化丁烷或苯来制备1,4-丁二醇和（如果需要的话）γ-丁内酯和THF以形成包含马来酸酐的产物流的方法，在吸收中用高沸点惰性溶剂从产物流中吸收马来酸酐 阶段以得到液体吸收产物，在酯化阶段用C1-C5酯化醇酯化液体吸收产物以形成包含相应的二酯和高沸点惰性溶剂的酯化产物，然后氢化酯化产物得到氢化产物 其包括价值的产物，1,4-丁二醇，如果需要的话，γ-丁内酯和四氢呋喃和酯化醇，并通过蒸馏分离成产物和酯化醇，并将酯化醇再循环到酯化反应 其包括通过蒸馏分离酯化产物成二酯和惰性溶剂 在氢化之前在减压下进行反应，将惰性溶剂循环到吸收阶段，并在固定床催化剂中使液相中的二酯氢化。