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1.发明申请METHODS FOR REMOVING TRIAZINE FROM N-METHYLIMIDAZOLE FOR SYNTHESIS OF OLIGONUCLEOTIDE 有权从N-甲基咪唑中除去三氮杂以合成寡核苷酸的方法公开(公告)号：US20150119564A1
公开(公告)日：2015-04-30
申请号：US14471635
申请日：2014-08-28
IPC分类号： C07D233/58 , C07H21/04 , C07H1/00
CPC分类号： C07D233/58 , C07H1/00 , C07H21/04
摘要： Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using N-methylimidazole are provided. In one embodiment, a method for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a feedstock containing N-methylimidazole includes contacting the feedstock with small or medium pore molecular sieves. The small or medium pore molecular sieves adsorb 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from the feedstock. The method further includes separating the small or medium pore molecular sieves from the feedstock.
摘要翻译： 提供了从N-甲基咪唑中除去1,3,5-三甲基六氢-1,3,5-三嗪和N-亚甲基甲胺的方法以及使用N-甲基咪唑制备寡核苷酸的方法。 在一个实施方案中，从含有N-甲基咪唑的原料中除去1,3,5-三甲基六氢-1,3,5-三嗪和N-亚甲基甲胺的方法包括使原料与中孔分子筛接触。 小孔或中孔分子筛从原料中吸附1,3,5-三甲基六氢-1,3,5-三嗪和N-亚甲基甲胺。 该方法还包括从原料中分离出小孔或中孔分子筛。
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2.发明授权Methods for removing triazine from N-methylimidazole for synthesis of oligonucleotide 有权从N-甲基咪唑中除去三嗪以合成寡核苷酸的方法公开(公告)号：US09556124B2
公开(公告)日：2017-01-31
申请号：US14471635
申请日：2014-08-28
IPC分类号： C07H21/00 , C07D233/00 , C07D233/58 , C07H1/00 , C07H21/04
CPC分类号： C07D233/58 , C07H1/00 , C07H21/04
摘要： Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using N-methylimidazole are provided. In one embodiment, a method for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a feedstock containing N-methylimidazole includes contacting the feedstock with small or medium pore molecular sieves. The small or medium pore molecular sieves adsorb 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from the feedstock. The method further includes separating the small or medium pore molecular sieves from the feedstock.
摘要翻译： 提供了从N-甲基咪唑中除去1,3,5-三甲基六氢-1,3,5-三嗪和N-亚甲基甲胺的方法以及使用N-甲基咪唑制备寡核苷酸的方法。 在一个实施方案中，从含有N-甲基咪唑的原料中除去1,3,5-三甲基六氢-1,3,5-三嗪和N-亚甲基甲胺的方法包括使原料与中孔分子筛接触。 小孔或中孔分子筛从原料中吸附1,3,5-三甲基六氢-1,3,5-三嗪和N-亚甲基甲胺。 该方法还包括从原料中分离出小孔或中孔分子筛。
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