公开(公告)号：US20180085344A1

公开(公告)日：2018-03-29

申请号：US15710842

申请日：2017-09-21

申请人： Hong Kong Baptist University

发明人： Hongjie ZHANG ,  Man Shing Ricky WONG ,  Lei GUO ,  Siu Wai TSANG ,  Kanglun LIU ,  Tongxin ZHANG

IPC分类号： A61K31/357 ,  A61K31/22 ,  A61K45/06 ,  C07C69/12 ,  C07D319/08 ,  C07D493/08

CPC分类号： A61K31/357 ,  A61K31/22 ,  C07C69/18 ,  C07C2603/86 ,  C07D319/08 ,  C07D493/08

摘要： The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.