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1.发明申请Method of Using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions 有权在纤维化和糖尿病状态治疗中使用二氢白藜芦醇或其芪衍生物和/或化学变体的方法公开(公告)号：US20170057896A1
公开(公告)日：2017-03-02
申请号：US15351636
申请日：2016-11-15
发明人： Hongjie ZHANG , Siu Wai TSANG , Yegao CHEN
CPC分类号： A61K8/347 , A61K8/33 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C69/34 , C07C69/736 , C07C69/753 , C07C2601/08
摘要： A polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
摘要翻译： 公知的二萜类家族的多酚衍生物即反式-3,5,4'-三羟基联苄（又称二氢白藜芦醇）作为补救剂。 特别地，提出了二氢白藜芦醇作为抗纤维化剂抑制胰岛细胞（PSC）活化的用途。 一个实施方案还涉及胰腺纤维化的治疗，胰腺纤维化通常伴有慢性胰腺炎和胰腺癌的发育不良反应。 另一个实施方案可用于预防或缓解或治疗胰腺癌或胰腺癌。
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公开(公告)号：US20170290782A1
公开(公告)日：2017-10-12
申请号：US15633780
申请日：2017-06-27
发明人： Hongjie ZHANG , Siu Wai TSANG , Yegao CHEN
IPC分类号： A61K31/09 , A61K31/05 , A61K9/00 , A61K31/085
CPC分类号： A61K8/347 , A61K8/33 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C69/34 , C07C69/736 , C07C69/753 , C07C2601/08
摘要： The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
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公开(公告)号：US20160221907A1
公开(公告)日：2016-08-04
申请号：US15071222
申请日：2016-03-16
发明人： Min LI , Juxian SONG , Chuanbin YANG , Yu ZENG , Sandeep MALAMPATI , Hongjie ZHANG
IPC分类号： C07C49/223 , C07C49/255 , A61K9/00 , C07C49/248 , A61K31/12 , C07C49/235
CPC分类号： C07C49/223 , A61K9/0053 , A61K31/12 , C07C49/235 , C07C49/248 , C07C49/255
摘要： The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.
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公开(公告)号：US20180085344A1
公开(公告)日：2018-03-29
申请号：US15710842
申请日：2017-09-21
发明人： Hongjie ZHANG , Man Shing Ricky WONG , Lei GUO , Siu Wai TSANG , Kanglun LIU , Tongxin ZHANG
IPC分类号： A61K31/357 , A61K31/22 , A61K45/06 , C07C69/12 , C07D319/08 , C07D493/08
CPC分类号： A61K31/357 , A61K31/22 , C07C69/18 , C07C2603/86 , C07D319/08 , C07D493/08
摘要： The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.
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公开(公告)号：US20170057906A1
公开(公告)日：2017-03-02
申请号：US15352903
申请日：2016-11-16
发明人： Hongjie ZHANG , Siu Wai TSANG , Yu ZHU
IPC分类号： C07C69/80 , C07C43/205 , C07C43/215 , C07C69/34 , A61K8/34 , A61K8/37 , A61K8/33 , A61Q19/02 , A61Q17/04 , C07C39/21 , C07C69/736 , C07C69/753
CPC分类号： A61K8/347 , A61K8/33 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C69/34 , C07C69/736 , C07C69/753 , C07C2601/08
摘要： A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
摘要翻译： 显示出一种皮肤保护组合物，其包含从石斛属植物获得的含有萜烯和/或芪类的提取物，例如石斛兰和石斛石斛用于管理黑素生成，皮肤变暗和皮肤老化。 更具体地说，石斛成分和芪类化合物的使用被证明可以减少黑素细胞中黑色素的形成。 还显示石斛粉成分和芪类化合物的使用可以减少活性氧和氧化自由基的产生。 在皮肤保护，皮肤美白和/或抗皮肤衰老产品的配方中显示了使用石斛衍生的提取物或成分或芪类化合物。
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公开(公告)号：US20230248754A1
公开(公告)日：2023-08-10
申请号：US18173865
申请日：2023-02-24
发明人： Hongjie ZHANG , Wanfei LI , Nga Yi TSANG
IPC分类号： A61K31/69 , A61K31/365 , A61K31/506 , A61K31/443 , A61P31/16 , A61K31/5377 , A61K31/7048 , A61K31/706 , A61P31/18 , A61K31/381
CPC分类号： A61K31/69 , A61K31/365 , A61K31/506 , A61K31/443 , A61P31/16 , A61K31/5377 , A61K31/7048 , A61K31/706 , A61P31/18 , A61K31/381
摘要： The present disclosure relates to patentiflorin A analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.
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公开(公告)号：US20210060042A1
公开(公告)日：2021-03-04
申请号：US16947935
申请日：2020-08-25
发明人： Hongjie ZHANG , Wanfei LI , Nga Yi TSANG
IPC分类号： A61K31/69 , A61K31/365 , A61K31/506 , A61K31/443 , A61K31/381 , A61K31/5377 , A61K31/7048 , A61K31/706 , A61P31/18 , A61P31/16
摘要： The present disclosure relates to patentiflorin A analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.
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8.发明申请公开(公告)号：US20180319729A1
公开(公告)日：2018-11-08
申请号：US16030854
申请日：2018-07-09
发明人： Hongjie ZHANG , Siu Wai TSANG
IPC分类号： C07C43/23 , C07C39/16 , C07C37/00 , C07C43/215 , C07C39/21 , A61Q17/04 , C07C69/753 , C07C69/34 , A61Q19/02 , C07C69/736 , A61K31/05 , C07C43/205 , A61K8/33 , A61K8/37 , A61K8/34 , A61K31/085 , A61K31/09 , A61K9/00 , C07C39/15
CPC分类号： C07C43/23 , A61K8/33 , A61K8/347 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61K36/8984 , A61Q11/00 , A61Q17/005 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C69/30 , C07C69/34 , C07C69/616 , C07C69/712 , C07C69/736 , C07C69/74 , C07C69/753 , C07C69/76 , C07C69/78 , C07C69/92 , C07C2601/08
摘要： The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
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公开(公告)号：US20180118647A1
公开(公告)日：2018-05-03
申请号：US15849650
申请日：2017-12-20
发明人： Hongjie ZHANG , Siu Wai TSANG
CPC分类号： A61K8/347 , A61K8/33 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C69/34 , C07C69/736 , C07C69/753 , C07C2601/08
摘要： The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.
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公开(公告)号：US20240076299A1
公开(公告)日：2024-03-07
申请号：US18258224
申请日：2021-12-07
发明人： Hongjie ZHANG , Yu ZHU , Nga Yi TSANG , Yang ZHAO
IPC分类号： C07D493/04 , A61K31/365 , A61K36/19 , A61P31/14 , A61P31/16 , A61P31/18 , C07D407/14 , C07F7/18
CPC分类号： C07D493/04 , A61K31/365 , A61K36/19 , A61P31/14 , A61P31/16 , A61P31/18 , C07D407/14 , C07F7/1804
摘要： Provided herein are tuberculatin analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.
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