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公开(公告)号：US20240287120A1
公开(公告)日：2024-08-29
申请号：US18646230
申请日：2024-04-25
发明人： Wing C. Poon , Xiaoyang Guan , David Yu , Ruiming Zou , Xiaojun Li , Michael Su , Gang Zhao , Gengyu Du , Yun-Chiao Yao , Aldrich N.K. Lau
摘要： Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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公开(公告)号：US20230279041A1
公开(公告)日：2023-09-07
申请号：US18065503
申请日：2022-12-13
发明人： Wing C. Poon , Xiaoyang Guan , David Yu , Ruiming Zou , Xiaojun Li , Michael Su , Gang Zhao , Gengyu Du , Yun-Chiao Yao
摘要： Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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公开(公告)号：US11993626B2
公开(公告)日：2024-05-28
申请号：US18065503
申请日：2022-12-13
发明人： Wing C. Poon , Xiaoyang Guan , David Yu , Ruiming Zou , Xiaojun Li , Michael Su , Gang Zhao , Gengyu Du , Yun-Chiao Yao , Aldrich N. K. Lau
摘要： Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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