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公开(公告)号：US12065460B2
公开(公告)日：2024-08-20
申请号：US18505877
申请日：2023-11-09
Applicant: Hongene Biotech Corporation
Inventor： Gaomai Yang , Yun-Chiao Yao , David Yu , Aldrich N. K. Lau
IPC: C07H1/00 , C07H21/00 , C08F120/68 , C08F220/28 , C08F220/56 , C08F265/10
CPC classification number: C07H1/00 , C07H21/00 , C08F120/68 , C08F220/286 , C08F220/56 , C08F265/10
Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
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公开(公告)号：US20230212209A1
公开(公告)日：2023-07-06
申请号：US18146279
申请日：2022-12-23
Applicant: Hongene Biotech Corporation
Inventor： Gaomai Yang , Yun-Chiao Yao , David Yu , Aldrich N.K. Lau
IPC: C07H1/00 , C08F220/56 , C07H21/00 , C08F265/10 , C08F220/28 , C08F120/68
CPC classification number: C07H1/00 , C08F220/56 , C07H21/00 , C08F265/10 , C08F220/286 , C08F120/68
Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
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公开(公告)号：US20230130509A1
公开(公告)日：2023-04-27
申请号：US18048350
申请日：2022-10-20
Applicant: Hongene Biotech Corporation
Inventor： Jingshe Song , John Michael Cue , Yun-Chiao Yao , David Yu , Aldrich N.K. Lau
Abstract: Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.
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公开(公告)号：US20250034192A1
公开(公告)日：2025-01-30
申请号：US18902678
申请日：2024-09-30
Applicant: Hongene Biotech Corporation
Inventor： Gaomai Yang , Jingshe Song , Shengdong Wang , Yun-Chiao Yao , Hongrong Yang , David Yu , Aldrich N.K. Lau
IPC: C07H1/00 , C08F120/68 , C08F220/28 , C08F220/56 , C08F265/10
Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.
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公开(公告)号：US20240287120A1
公开(公告)日：2024-08-29
申请号：US18646230
申请日：2024-04-25
Applicant: Hongene Biotech Corporation
Inventor： Wing C. Poon , Xiaoyang Guan , David Yu , Ruiming Zou , Xiaojun Li , Michael Su , Gang Zhao , Gengyu Du , Yun-Chiao Yao , Aldrich N.K. Lau
Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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Patent Agency Ranking
公开(公告)号：US20240117362A1
公开(公告)日：2024-04-11
申请号：US18451013
申请日：2023-08-16
Applicant: Hongene Biotech Corporation
Inventor： Mufa Zou , David Yu , Aldrich N.K. Lau , Ruiming Zou , Wing C. Poon , Gang Zhao , Gengyu Du , Yun-Chiao Yao , Allen Wong , Xiaojun Li
IPC: C12N15/117 , B01J19/00
CPC classification number: C12N15/117 , B01J19/0046 , C12N2310/14 , C12N2310/17 , C12N2310/3515
Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
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公开(公告)号：US20240092817A1
公开(公告)日：2024-03-21
申请号：US18505877
申请日：2023-11-09
Applicant: Hongene Biotech Corporation
Inventor： Gaomai Yang , Yun-Chiao Yao , David Yu , Aldrich N.K. Lau
IPC: C07H1/00 , C07H21/00 , C08F120/68 , C08F220/28 , C08F220/56 , C08F265/10
CPC classification number: C07H1/00 , C07H21/00 , C08F120/68 , C08F220/286 , C08F220/56 , C08F265/10
Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
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公开(公告)号：US11897914B2
公开(公告)日：2024-02-13
申请号：US18059357
申请日：2022-11-28
Applicant: Hongene Biotech Corporation
Inventor： Wing C. Poon , Ruiming Zou , Aldrich N. K. Lau , David Yu , Gengyu Du , Yun-Chiao Yao , Gang Zhao
IPC: C07H21/02 , C07H19/10 , C07H19/067 , C07H19/167 , C07H19/20 , C07H23/00
CPC classification number: C07H21/02 , C07H19/067 , C07H19/10 , C07H19/167 , C07H19/20 , C07H23/00
Abstract: Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.
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公开(公告)号：US20240002420A1
公开(公告)日：2024-01-04
申请号：US18337233
申请日：2023-06-19
Applicant: Hongene Biotech Corporation
Inventor： Gaomai Yang , Jingshe Song , Shengdong Wang , Yun-Chiao Yao , Hongrong Yang , David Yu , Aldrich N.K. Lau
IPC: C07H1/00 , C08F120/68 , C08F220/28 , C08F220/56 , C08F265/10
CPC classification number: C07H1/00 , C08F120/68 , C08F220/286 , C08F220/56 , C08F265/10
Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.
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公开(公告)号：US11851454B2
公开(公告)日：2023-12-26
申请号：US18146279
申请日：2022-12-23
Applicant: Hongene Biotech Corporation
Inventor： Gaomai Yang , Yun-Chiao Yao , David Yu , Aldrich N. K. Lau
IPC: C07H1/00 , C07H21/00 , C08F220/56 , C08F265/10 , C08F220/28 , C08F120/68
CPC classification number: C07H1/00 , C07H21/00 , C08F120/68 , C08F220/286 , C08F220/56 , C08F265/10
Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
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