公开(公告)号：US20100228014A1

公开(公告)日：2010-09-09

申请号：US12160359

申请日：2007-01-18

申请人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Kiu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

发明人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Kiu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

IPC分类号： C07H17/04 ,  C07D311/02 ,  C07H1/00

CPC分类号： C07D311/94

摘要： Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives.

摘要翻译： 新型萜烯二萜化合物及其衍生物及其制备方法及应用。 本发明中的--二萜可用作制备不对称有机化合物和药物的所需中间体，可用作抗肿瘤剂，抗炎剂和免疫剂等。所述萜烯二萜化合物可与 羟基化合物以获得各种缩醛衍生物，可以与胺化合物反应以获得各种氨基衍生物，并且可以与酰基卤或酸酐反应得到各种酰基衍生物。

公开(公告)号：US08084430B2

公开(公告)日：2011-12-27

申请号：US12160359

申请日：2007-01-18

申请人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Liu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

发明人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Liu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/24 ,  C07D311/78

CPC分类号： C07D311/94

摘要： Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives.

摘要翻译： 新型萜烯二萜化合物及其衍生物及其制备方法及其应用。 本发明中的--二萜可用作制备不对称有机化合物和药物的所需中间体，可用作抗肿瘤剂，抗炎剂和免疫剂等。所述萜烯二萜化合物可与 羟基化合物以获得各种缩醛衍生物，可以与胺化合物反应以获得各种氨基衍生物，并且可以与酰基卤或酸酐反应得到各种酰基衍生物。