公开(公告)号：US08084430B2

公开(公告)日：2011-12-27

申请号：US12160359

申请日：2007-01-18

申请人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Liu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

发明人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Liu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/24 ,  C07D311/78

CPC分类号： C07D311/94

摘要： Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives.

摘要翻译： 新型萜烯二萜化合物及其衍生物及其制备方法及其应用。 本发明中的--二萜可用作制备不对称有机化合物和药物的所需中间体，可用作抗肿瘤剂，抗炎剂和免疫剂等。所述萜烯二萜化合物可与 羟基化合物以获得各种缩醛衍生物，可以与胺化合物反应以获得各种氨基衍生物，并且可以与酰基卤或酸酐反应得到各种酰基衍生物。

公开(公告)号：US20100228014A1

公开(公告)日：2010-09-09

申请号：US12160359

申请日：2007-01-18

申请人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Kiu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

发明人： Hongmin Liu ,  Wenchen Zhu ,  Chenggong Zhu ,  Qingduan Wang ,  Yu Ke ,  Zhengzhou Kiu ,  Xuebin Yan ,  Zhang Jianye ,  Hongli Qu

IPC分类号： C07H17/04 ,  C07D311/02 ,  C07H1/00

CPC分类号： C07D311/94

摘要： Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives.

摘要翻译： 新型萜烯二萜化合物及其衍生物及其制备方法及应用。 本发明中的--二萜可用作制备不对称有机化合物和药物的所需中间体，可用作抗肿瘤剂，抗炎剂和免疫剂等。所述萜烯二萜化合物可与 羟基化合物以获得各种缩醛衍生物，可以与胺化合物反应以获得各种氨基衍生物，并且可以与酰基卤或酸酐反应得到各种酰基衍生物。

公开(公告)号：USD966472S1

公开(公告)日：2022-10-11

申请号：US29864360

申请日：2022-05-23

申请人： Hongmin Liu

设计人： Hongmin Liu

公开(公告)号：US20150051403A1

公开(公告)日：2015-02-19

申请号：US14377386

申请日：2013-02-05

申请人： Guifu Dai ,  Songlin Zhu ,  Yanan Wang ,  Jian Wu ,  Dan Zhao ,  Di Wu ,  Huanfei Liu ,  Haiwei Xu ,  Mengjiao Liu ,  Jing Zhao ,  Wei Han ,  Zhenwei Wu ,  Hang Wang ,  Hongmin Liu

发明人： Guifu Dai ,  Songlin Zhu ,  Yanan Wang ,  Jian Wu ,  Dan Zhao ,  Di Wu ,  Huanfei Liu ,  Haiwei Xu ,  Mengjiao Liu ,  Jing Zhao ,  Wei Han ,  Zhenwei Wu ,  Hang Wang ,  Hongmin Liu

IPC分类号： C07D405/12 ,  C07D307/33 ,  C07D307/58

CPC分类号： A61K31/365 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/443 ,  A61K31/455 ,  A61K47/38 ,  C07D307/33 ,  C07D307/58 ,  C07D405/12

摘要： Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.

摘要翻译： 公开了通式1所示的穿心莲内酯衍生物在制备抗丙型肝炎病毒药物中的用途，以及预防和治疗由病毒感染引起的免疫性肝损伤和不同的化学肝损伤。

公开(公告)号：US09198894B2

公开(公告)日：2015-12-01

申请号：US13823841

申请日：2011-10-19

申请人： Fengjuan Wu ,  Guifu Dai ,  Haiwei Xu ,  Zhiwen Jiang ,  Liping Zhu ,  Lijun Yan ,  Hongmin Liu ,  Yanan Wang ,  Weiyi Li ,  Ruijing Dong

发明人： Fengjuan Wu ,  Guifu Dai ,  Haiwei Xu ,  Zhiwen Jiang ,  Liping Zhu ,  Lijun Yan ,  Hongmin Liu ,  Yanan Wang ,  Weiyi Li ,  Ruijing Dong

IPC分类号： A61K31/365 ,  C07D307/33 ,  A61K31/341 ,  A61K45/06

CPC分类号： A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07D307/33

摘要： The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity. Thereby it has potential to expand the selectable range of clinical drug and is of high significance to make full use of the plant resources of Andrographis paniculata.

摘要翻译： 本发明涉及具有穿心莲内酯衍生物的抗肿瘤药物的制备，属于制药领域，涉及14-脱氧-11,12-脱氢穿心莲内酯的15-亚苄基取代衍生物及其3,19- 酯衍生物。 通过实验证明，这些化合物显着抑制了各种癌细胞的集落形成和迁移能力，并且还抑制了体外血管内皮细胞的迁移能力。 本发明化合物显着抑制小鼠异种移植模型的肿瘤生长，侵袭，转移和血管生成，并抑制B16-F10恶性黑素瘤细胞的实验性肺转移。 因此，这类化合物可用作制备有效和低毒的抗肿瘤药物的活性成分。 因此，有可能扩大临床药物的可选范围，对充分利用穿心莲的植物资源具有重要意义。

公开(公告)号：US20130237596A1

公开(公告)日：2013-09-12

申请号：US13823841

申请日：2011-10-19

申请人： Guifu Dai ,  Haiwei Xu ,  Liping Zhu ,  Ruijing Dong ,  Fengjuan Wu ,  Yanan Wang ,  Zhiwen Jiang ,  Lijun Yan ,  Weiyi Li ,  Hongmin Liu

发明人： Guifu Dai ,  Haiwei Xu ,  Liping Zhu ,  Ruijing Dong ,  Fengjuan Wu ,  Yanan Wang ,  Zhiwen Jiang ,  Lijun Yan ,  Weiyi Li ,  Hongmin Liu

IPC分类号： A61K31/341 ,  A61K45/06 ,  C07D307/33

CPC分类号： A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07D307/33

摘要： The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity. Thereby it has potential to expand the selectable range of clinical drug and is of high significance to make full use of the plant resources of Andrographis paniculata.

摘要翻译： 本发明涉及具有穿心莲内酯衍生物的抗肿瘤药物的制备，属于制药领域，涉及14-脱氧-11,12-脱氢穿心莲内酯的15-亚苄基取代衍生物及其3,19- 酯衍生物。 通过实验证明，这些化合物显着抑制了各种癌细胞的集落形成和迁移能力，并且还抑制了体外血管内皮细胞的迁移能力。 本发明化合物显着抑制小鼠异种移植模型的肿瘤生长，侵袭，转移和血管生成，并抑制B16-F10恶性黑素瘤细胞的实验性肺转移。 因此，这类化合物可用作制备有效和低毒的抗肿瘤药物的活性成分。 因此，有可能扩大临床药物的可选范围，对充分利用穿心莲的植物资源具有重要意义。

公开(公告)号：US09388169B2

公开(公告)日：2016-07-12

申请号：US14377386

申请日：2013-02-05

申请人： Guifu Dai ,  Songlin Zhu ,  Yanan Wang ,  Jian Wu ,  Dan Zhao ,  Di Wu ,  Huanfei Liu ,  Haiwei Xu ,  Mengjiao Liu ,  Jing Zhao ,  Wei Han ,  Zhenwei Wu ,  Hang Wang ,  Hongmin Liu

发明人： Guifu Dai ,  Songlin Zhu ,  Yanan Wang ,  Jian Wu ,  Dan Zhao ,  Di Wu ,  Huanfei Liu ,  Haiwei Xu ,  Mengjiao Liu ,  Jing Zhao ,  Wei Han ,  Zhenwei Wu ,  Hang Wang ,  Hongmin Liu

IPC分类号： C07D405/00 ,  C07D405/12 ,  A61K31/365 ,  A61K31/443 ,  A61K9/00 ,  C07D307/33 ,  C07D307/58 ,  A61K47/38

CPC分类号： A61K31/365 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/443 ,  A61K31/455 ,  A61K47/38 ,  C07D307/33 ,  C07D307/58 ,  C07D405/12

摘要： Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.