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    Modulated release from biocompatible polymers
    1.
    发明授权
    Modulated release from biocompatible polymers 失效

    公开(公告)号：US06749866B2

    公开(公告)日：2004-06-15

    申请号：US10039285

    申请日：2002-01-03

    申请人： Howard Bernstein ,  Yan Zhang ,  M. Amin Khan ,  Mark A. Tracy

    发明人： Howard Bernstein ,  Yan Zhang ,  M. Amin Khan ,  Mark A. Tracy

    IPC分类号： A61K914

    CPC分类号： A61K9/7007 ,  A61K9/1611 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/212 ,  A61K38/27 ,  A61K38/35 ,  A61K38/465 ,  C12Y301/27005 ,  Y10S514/805 ,  Y10S514/965

    摘要： The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.

    Modulated release from biocompatible polymers
    3.
    发明授权
    Modulated release from biocompatible polymers 失效
    生物相容聚合物的调制释放

    公开(公告)号：US5656297A

    公开(公告)日：1997-08-12

    申请号：US237057

    申请日：1994-05-03

    申请人： Howard Bernstein ,  Yan Zhang ,  M. Amin Khan ,  Mark A. Tracy

    发明人： Howard Bernstein ,  Yan Zhang ,  M. Amin Khan ,  Mark A. Tracy

    IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/52 ,  A61K9/70 ,  A61K38/21 ,  A61K38/22 ,  A61K38/35 ,  A61K38/46 ,  A61K47/30 ,  A61K47/34 ,  A61K9/14

    CPC分类号： A61K9/1694 ,  A61K33/10 ,  A61K33/30 ,  A61K38/212 ,  A61K38/27 ,  A61K38/35 ,  A61K38/465 ,  A61K9/1611 ,  A61K9/1647 ,  A61K9/7007 ,  C12Y301/27005 ,  Y10S514/805 ,  Y10S514/935

    摘要： The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.

    摘要翻译： 本发明涉及用于调节释放生物活性剂的组合物。 组合物包含生物相容性聚合物基质，分散在聚合物基质内的生物活性剂和分散分散在聚合物基质内的金属阳离子组分，由此金属阳离子组分调节生物活性剂从聚合物中的释放 矩阵。 本发明还涉及一种用于调节生物相容性聚合物基质释放生物活性剂的方法，包括以下步骤：将生物相容性聚合物溶解在溶剂中以形成聚合物溶液，并且还分别分散金属阳离子组分和生物相容性聚合物 聚合物溶液中的活性剂。 然后将聚合物溶液固化以形成聚合物基质，其中至少大部分金属阳离子组分与生物活性蛋白质分开分散在聚合物基质中，由此金属阳离子组分调节生物活性剂的释放 从聚合物基质。

    Modulated release from biocompatible polymers
    4.
    发明授权
    Modulated release from biocompatible polymers 失效

    公开(公告)号：US06368630B1

    公开(公告)日：2002-04-09

    申请号：US09274613

    申请日：1999-03-23

    申请人： Howard Bernstein ,  Yan Zhang ,  M. Amin Khan ,  Mark A. Tracy

    发明人： Howard Bernstein ,  Yan Zhang ,  M. Amin Khan ,  Mark A. Tracy

    IPC分类号： A61K914

    CPC分类号： A61K9/7007 ,  A61K9/1611 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/212 ,  A61K38/27 ,  A61K38/35 ,  A61K38/465 ,  C12Y301/27005 ,  Y10S514/805 ,  Y10S514/965

    摘要： The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.

    Controlled release of metal cation-stabilized interferon
    5.
    发明授权
    Controlled release of metal cation-stabilized interferon 失效
    金属阳离子稳定的干扰素的控制释放

    公开(公告)号：US06780434B2

    公开(公告)日：2004-08-24

    申请号：US10092365

    申请日：2002-03-06

    申请人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    发明人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    IPC分类号： A61K910

    CPC分类号： B82Y5/00 ,  A61K9/1611 ,  A61K9/1647 ,  A61K38/212 ,  C07K14/56

    摘要： This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.

    摘要翻译： 本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。 本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒，其中颗粒分散在生物相容性聚合物内。 本发明的制备用于干扰素控制释放的组合物的方法包括将聚合物溶解在聚合物溶剂中以形成聚合物溶液，将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中，然后固化聚合物 以形成含有干扰素颗粒的分散体的聚合物基质。

    Controlled release of metal cation-stabilized interferon
    6.
    发明授权
    Controlled release of metal cation-stabilized interferon 失效
    金属阳离子稳定的干扰素的控制释放

    公开(公告)号：US06379701B1

    公开(公告)日：2002-04-30

    申请号：US09664299

    申请日：2000-09-18

    申请人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    发明人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    IPC分类号： A61K910

    CPC分类号： B82Y5/00 ,  A61K9/1611 ,  A61K9/1647 ,  A61K38/212 ,  C07K14/56

    摘要： This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.

    摘要翻译： 本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。 本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒，其中颗粒分散在生物相容性聚合物内。本发明的用于制备用于控制释放干扰素的组合物的方法包括将 聚合物在聚合物溶剂中以形成聚合物溶液，将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中，然后固化聚合物以形成含有干扰素颗粒分散体的聚合物基质。

    Controlled release of metal cation-stabilized interferon
    7.
    发明授权
    Controlled release of metal cation-stabilized interferon 失效
    金属阳离子稳定的干扰素的控制释放

    公开(公告)号：US6165508A

    公开(公告)日：2000-12-26

    申请号：US765558

    申请日：1997-03-07

    申请人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    发明人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    IPC分类号： A61K9/16 ,  A61K38/21 ,  A61K47/30 ,  C07K14/56 ,  A61K9/10

    CPC分类号： B82Y5/00 ,  A61K9/1611 ,  A61K9/1647 ,  A61K38/212 ,  C07K14/56

    摘要： This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation-stabilized interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.

    摘要翻译： 本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。 本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒，其中颗粒分散在生物相容性聚合物内。 本发明的制备用于控制干扰素释放的组合物的方法包括将聚合物溶解在聚合物溶剂中以形成聚合物溶液，将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中，然后固化聚合物 以形成含有干扰素颗粒的分散体的聚合物基质。

    Composition and method for the controlled release of metal cation-stabilized interferon
    9.
    发明授权
    Composition and method for the controlled release of metal cation-stabilized interferon 失效
    金属阳离子稳定化干扰素的控制释放的组成和方法

    公开(公告)号：US5711968A

    公开(公告)日：1998-01-27

    申请号：US279784

    申请日：1994-07-25

    申请人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    发明人： Mark A. Tracy ,  Howard Bernstein ,  M. Amin Khan

    IPC分类号： A61K9/16 ,  A61K38/21 ,  A61K47/30 ,  C07K14/56 ,  A61K9/10

    CPC分类号： B82Y5/00 ,  A61K38/212 ,  A61K9/1611 ,  A61K9/1647 ,  C07K14/56

    摘要： This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.

    摘要翻译： 本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。 本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒，其中颗粒分散在生物相容性聚合物内。 本发明的制备用于干扰素控制释放的组合物的方法包括将聚合物溶解在聚合物溶剂中以形成聚合物溶液，将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中，然后固化聚合物 以形成含有干扰素颗粒的分散体的聚合物基质。