公开(公告)号：US20230240553A1

公开(公告)日：2023-08-03

申请号：US18127538

申请日：2023-03-28

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01V3/10 ,  G01R33/36 ,  G01R33/60 ,  G01R33/341

CPC分类号： A61B5/055 ,  G01V3/104 ,  G01R33/3621 ,  G01R33/3607 ,  G01R33/60 ,  G01R33/341

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

公开(公告)号：US20160324438A1

公开(公告)日：2016-11-10

申请号：US15213768

申请日：2016-07-19

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60

CPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/104

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

摘要翻译： 使用高隔离发射/接收表面线圈和时间间隔的RF能量的脉冲（例如，在一些实施例中，RF pi脉冲）中用于改善在原位和体内电子顺磁共振成像的S / N测量的装置和方法， 具有足够的振幅，以便在变化的延迟之后将磁化旋转180度，通过具有振幅为初始脉冲的一半的第二RF脉冲将磁化旋转例如90度（一个π/ 2脉冲））到 与静态场正交的平面，其演化时间短。 然后，足以使磁化旋转例如180度的第三RF pi脉冲形成回波（在一些实施例中，第二和第三脉冲来自与第一脉冲相同的信号，但是相位偏移0,90,180 ，或270度以减少信号伪影），以形象人体。

公开(公告)号：US11612336B2

公开(公告)日：2023-03-28

申请号：US15213768

申请日：2016-07-19

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01R33/36 ,  G01V3/10

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

公开(公告)号：US09392957B1

公开(公告)日：2016-07-19

申请号：US13032637

申请日：2011-02-22

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01R33/60 ,  G01R33/341

CPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/104

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

摘要翻译： 使用高隔离发射/接收表面线圈和时间间隔的RF能量的脉冲（例如，在一些实施例中，RF pi脉冲）中用于改善在原位和体内电子顺磁共振成像的S / N测量的装置和方法， 具有足够的振幅，以便在变化的延迟之后将磁化旋转180度，通过具有振幅为初始脉冲的一半的第二RF脉冲将磁化旋转例如90度（一个π/ 2脉冲））到 与静态场正交的平面，其演化时间短。 然后，足以使磁化旋转例如180度的第三RF pi脉冲形成回波（在一些实施例中，第二和第三脉冲来自与第一脉冲相同的信号，但是相位偏移0,90,180 ，或270度以减少信号伪影），以形象人体。

公开(公告)号：US10551450B2

公开(公告)日：2020-02-04

申请号：US14128423

申请日：2012-06-14

申请人： Howard Halpern ,  Subramanian V. Sundramoorthy ,  Boris Epel

发明人： Howard Halpern ,  Subramanian V. Sundramoorthy ,  Boris Epel

IPC分类号： G01R33/343 ,  G01R33/60

摘要： Techniques provide for passive Q switching in a bimodal resonator environment, where magnetic resonators are coupled for power transfer. A passive Q switch is responsive to a driving power from one magnetic resonator coupled to another magnetic resonator. After the driving power reaches a threshold, the passive Q switch shunts the receiving magnetic resonator, at least partially, to reduce the Q of that second resonator, which allows faster detection operation of the second resonator in some applications. The technique allows for fast Q switching in a bimodal resonator system, especially one having resonators having magnetic fields that are orthogonal to one another.

公开(公告)号：US20150022209A1

公开(公告)日：2015-01-22

申请号：US14128423

申请日：2012-06-14

申请人： Howard Halpern ,  Subramanian V. Sundramoorthy ,  Boris Epel

发明人： Howard Halpern ,  Subramanian V. Sundramoorthy ,  Boris Epel

IPC分类号： G01R33/343 ,  G01R33/60

CPC分类号： G01R33/343 ,  A61B5/055 ,  G01R33/34069 ,  G01R33/3671 ,  G01R33/60

摘要： Techniques provide for passive Q switching in a bimodal resonator environment, where magnetic resonators are coupled for power transfer. A passive Q switch is responsive to a driving power from one magnetic resonator coupled to another magnetic resonator. After the driving power reaches a threshold, the passive Q switch shunts the receiving magnetic resonator, at least partially, to reduce the Q of that second resonator, which allows faster detection operation of the second resonator in some applications. The technique allows for fast Q switching in a bimodal resonator system, especially one having resonators having magnetic fields that are orthogonal to one another.

摘要翻译： 技术在双模谐振器环境中提供无源Q开关，其中磁共振器耦合用于功率传输。 无源Q开关响应于耦合到另一个磁共振器的一个磁共振器的驱动功率。 在驱动功率达到阈值之后，无源Q开关至少部分地分流接收磁共振器，以减小该第二谐振器的Q，这允许在一些应用中更快地检测第二谐振器的操作。 该技术允许双模谐振器系统中的快速Q开关，特别是具有彼此正交的具有磁场的谐振器的谐振器。