公开(公告)号：US20230240553A1

公开(公告)日：2023-08-03

申请号：US18127538

申请日：2023-03-28

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01V3/10 ,  G01R33/36 ,  G01R33/60 ,  G01R33/341

CPC分类号： A61B5/055 ,  G01V3/104 ,  G01R33/3621 ,  G01R33/3607 ,  G01R33/60 ,  G01R33/341

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

公开(公告)号：US20160324438A1

公开(公告)日：2016-11-10

申请号：US15213768

申请日：2016-07-19

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60

CPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/104

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

摘要翻译： 使用高隔离发射/接收表面线圈和时间间隔的RF能量的脉冲（例如，在一些实施例中，RF pi脉冲）中用于改善在原位和体内电子顺磁共振成像的S / N测量的装置和方法， 具有足够的振幅，以便在变化的延迟之后将磁化旋转180度，通过具有振幅为初始脉冲的一半的第二RF脉冲将磁化旋转例如90度（一个π/ 2脉冲））到 与静态场正交的平面，其演化时间短。 然后，足以使磁化旋转例如180度的第三RF pi脉冲形成回波（在一些实施例中，第二和第三脉冲来自与第一脉冲相同的信号，但是相位偏移0,90,180 ，或270度以减少信号伪影），以形象人体。

公开(公告)号：US20140285198A1

公开(公告)日：2014-09-25

申请号：US14196982

申请日：2014-03-04

申请人： Howard J. Halpern

发明人： Howard J. Halpern

IPC分类号： G01R33/60

CPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/104

摘要： The present invention provides an apparatus and a corresponding method useful for electron paramagnetic resonance imaging, in situ and in vivo, using high-isolation transmit/receive (TX/RX) coils, which, in some embodiments, provide microenvironmental images that are representative of particular internal structures in the human body and spatially resolved images of tissue/cell protein signals responding to conditions (such as hypoxia) that show the temporal sequence of certain biological processes, and, in some embodiments, that distinguish malignant tissue from healthy tissue. In some embodiments, the TX/RX coils are in a surface, volume or surface-volume configuration. In some embodiments, the transmit coils are oriented to generate an RF magnetic field in directions substantially orthogonal to a static gradient field, and the receive coils are oriented to sense RF EPR signal in directions substantially orthogonal to the transmitted field and to the static field, to minimize coupling of the transmitted signal to the receive coils.

摘要翻译： 本发明提供了使用高隔离发射/接收（TX / RX）线圈的原位和体内对于电子顺磁共振成像有用的装置和相应的方法，其在一些实施例中提供代表以下的微环境图像： 响应于显示某些生物过程的时间序列的条件（例如缺氧），并且在一些实施方案中，将恶性组织与健康组织区分开来，人体中特定的内部结构和组织/细胞蛋白质信号的空间分辨图像。 在一些实施例中，TX / RX线圈处于表面，体积或表面体积配置。 在一些实施例中，发射线圈被定向以在与静态梯度场基本正交的方向上产生RF磁场，并且接收线圈被定向以在基本上正交于发射场和静态场的方向上感测RF EPR信号， 以使发射信号与接收线圈的耦合最小化。

公开(公告)号：US11612336B2

公开(公告)日：2023-03-28

申请号：US15213768

申请日：2016-07-19

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01R33/36 ,  G01V3/10

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

公开(公告)号：US09392957B1

公开(公告)日：2016-07-19

申请号：US13032637

申请日：2011-02-22

申请人： Howard J. Halpern ,  Boris Epel

发明人： Howard J. Halpern ,  Boris Epel

IPC分类号： A61B5/055 ,  G01R33/60 ,  G01R33/341

CPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/104

摘要： An apparatus and method for improved S/N measurements useful for electron paramagnetic resonance imaging in situ and in vivo, using high-isolation transmit/receive surface coils and temporally spaced pulses of RF energy (e.g., in some embodiments, a RF pi pulse) having an amplitude sufficient to rotate the magnetization by 180 degrees followed after varied delays, by a second RF pulse having an amplitude half that of the initial pulse to rotate the magnetization by, e.g., 90 degrees (a pi/2 pulse), to the plane orthogonal to the static field where it evolves for a short time. Then a third RF pi pulse sufficient to rotate the magnetization by, e.g., 180 degrees, forms an echo (in some embodiments, the second and third pulses are from the same signal as the first pulse but are phase shifted by 0, 90, 180, or 270 degrees to reduce signal artifact), to image human body.

摘要翻译： 使用高隔离发射/接收表面线圈和时间间隔的RF能量的脉冲（例如，在一些实施例中，RF pi脉冲）中用于改善在原位和体内电子顺磁共振成像的S / N测量的装置和方法， 具有足够的振幅，以便在变化的延迟之后将磁化旋转180度，通过具有振幅为初始脉冲的一半的第二RF脉冲将磁化旋转例如90度（一个π/ 2脉冲））到 与静态场正交的平面，其演化时间短。 然后，足以使磁化旋转例如180度的第三RF pi脉冲形成回波（在一些实施例中，第二和第三脉冲来自与第一脉冲相同的信号，但是相位偏移0,90,180 ，或270度以减少信号伪影），以形象人体。

公开(公告)号：US08664955B1

公开(公告)日：2014-03-04

申请号：US13032626

申请日：2011-02-22

申请人： Howard J. Halpern

发明人： Howard J. Halpern

IPC分类号： G01V3/00

CPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/104

摘要： The present invention provides an apparatus and a corresponding method useful for electron paramagnetic resonance imaging, in situ and in vivo, using high-isolation transmit/receive (TX/RX) coils, which, in some embodiments, provide microenvironmental images that are representative of particular internal structures in the human body and spatially resolved images of tissue/cell protein signals responding to conditions (such as hypoxia) that show the temporal sequence of certain biological processes, and, in some embodiments, that distinguish malignant tissue from healthy tissue. In some embodiments, the TX/RX coils are in a surface, volume or surface-volume configuration. In some embodiments, the transmit coils are oriented to generate an RF magnetic field in directions substantially orthogonal to a static gradient field, and the receive coils are oriented to sense RF EPR signal in directions substantially orthogonal to the transmitted field and to the static field, to minimize coupling of the transmitted signal to the receive coils.

摘要翻译： 本发明提供了使用高隔离发射/接收（TX / RX）线圈的原位和体内对电子顺磁共振成像有用的装置和相应的方法，其在一些实施例中提供了代表 响应于显示某些生物过程的时间序列的条件（例如缺氧），并且在一些实施方案中，将恶性组织与健康组织区分开来，人体中特定的内部结构和组织/细胞蛋白质信号的空间分辨图像。 在一些实施例中，TX / RX线圈处于表面，体积或表面体积配置。 在一些实施例中，发射线圈被定向以在与静态梯度场基本正交的方向上产生RF磁场，并且接收线圈被定向以在基本上正交于发射场和静态场的方向上感测RF EPR信号， 以使发射信号与接收线圈的耦合最小化。

公开(公告)号：US10568537B2

公开(公告)日：2020-02-25

申请号：US14196982

申请日：2014-03-04

申请人： Howard J. Halpern

发明人： Howard J. Halpern

IPC分类号： G01R33/60 ,  A61B5/055 ,  G01V3/10 ,  G01R33/341

摘要： The present invention provides an apparatus and a corresponding method useful for electron paramagnetic resonance imaging, in situ and in vivo, using high-isolation transmit/receive (TX/RX) coils, which, in some embodiments, provide microenvironmental images that are representative of particular internal structures in the human body and spatially resolved images of tissue/cell protein signals responding to conditions (such as hypoxia) that show the temporal sequence of certain biological processes, and, in some embodiments, that distinguish malignant tissue from healthy tissue. In some embodiments, the TX/RX coils are in a surface, volume or surface-volume configuration. In some embodiments, the transmit coils are oriented to generate an RF magnetic field in directions substantially orthogonal to a static gradient field, and the receive coils are oriented to sense RF EPR signal in directions substantially orthogonal to the transmitted field and to the static field, to minimize coupling of the transmitted signal to the receive coils.

公开(公告)号：US5431901A

公开(公告)日：1995-07-11

申请号：US227793

申请日：1988-08-03

申请人： Howard J. Halpern ,  Beverly A. Teicher

发明人： Howard J. Halpern ,  Beverly A. Teicher

IPC分类号： A61K49/20 ,  C07B60/00 ,  C07D207/46 ,  C07D211/94

CPC分类号： A61K49/20 ,  C07B61/02 ,  C07D207/46 ,  Y10T436/24

摘要： Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramagnetic species, such as the determination of oxygen tension in solution or in a biological sample, like a living organism. Spin label compounds, such as nitroxides, like 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl (CTPO), are selectively, but not completely, isotopically-labeled, such as partially deuterated, to increase the sensitivity and reliability of assays employing electron spin resonance spectroscopic measurements.

摘要翻译： 用于电子自旋共振光谱法的自旋标记化合物的选择性同位素标记用于检测，测量和监测顺磁性物质的存在，增加了电子自旋共振技术在顺磁性物质的测定中的灵敏度，例如测定氧气张力 溶液或生物样品，如活体。 旋转标记化合物，例如硝基氧，如3-氨基甲酰基-2,2,5,5-四甲基-3-吡咯啉-1-基氧基（CTPO），是选择性但不完全同位素标记的，例如部分氘代， 以提高使用电子自旋共振光谱测量的测定的灵敏度和可靠性。

公开(公告)号：US4714886A

公开(公告)日：1987-12-22

申请号：US755666

申请日：1985-07-16

申请人： Howard J. Halpern

发明人： Howard J. Halpern

IPC分类号： A61B5/055 ,  G01N24/10 ,  G01R33/345 ,  G01R33/385 ,  G01R33/60 ,  G01R33/20

CPC分类号： G01R33/60 ,  G01R33/345 ,  G01R33/385

摘要： Magnetic resonance images of the distribution of a substance within a sample are obtained by splaying a pair of magnetic field generating coils relative to each other to generate a magnetic field gradient along an axis of the sample. In other aspects, electron spin resonance data is derived from animal tissue, or images are derived from a sample that includes dissipative material, using a radio frequency signal of sufficiently low frequency.

摘要翻译： 通过相对于彼此张开一对磁场产生线圈来获得样品中物质分布的磁共振图像，以沿着样品轴产生磁场梯度。 在其它方面，电子自旋共振数据来源于动物组织，或者使用具有足够低频率的射频信号从包括耗散材料的样品中导出图像。

公开(公告)号：US11583203B2

公开(公告)日：2023-02-21

申请号：US16801021

申请日：2020-02-25

申请人： Howard J. Halpern

发明人： Howard J. Halpern

IPC分类号： A61B5/055 ,  G01R33/341 ,  G01R33/60 ,  G01V3/10 ,  G01R33/36

摘要： The present invention provides an apparatus and a corresponding method useful for electron paramagnetic resonance imaging, in situ and in vivo, using high-isolation transmit/receive (TX/RX) coils, which, in some embodiments, provide microenvironmental images that are representative of particular internal structures in the human body and spatially resolved images of tissue/cell protein signals responding to conditions (such as hypoxia) that show the temporal sequence of certain biological processes, and, in some embodiments, that distinguish malignant tissue from healthy tissue. In some embodiments, the TX/RX coils are in a surface, volume or surface-volume configuration. In some embodiments, the transmit coils are oriented to generate an RF magnetic field in directions substantially orthogonal to a static gradient field, and the receive coils are oriented to sense RF EPR signal in directions substantially orthogonal to the transmitted field and to the static field, to minimize coupling of the transmitted signal to the receive coils.