公开(公告)号：US20060026702A1

公开(公告)日：2006-02-02

申请号：US10902137

申请日：2004-07-30

申请人： Howard Rockman ,  Sathyamangla Naga Prasad ,  Stephane Laporte ,  Larry Barak ,  Marc Caron

发明人： Howard Rockman ,  Sathyamangla Naga Prasad ,  Stephane Laporte ,  Larry Barak ,  Marc Caron

IPC分类号： G01N33/53 ,  G01N33/567 ,  A01K67/027

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/10

摘要： The present invention relates to compounds that alter GPCR internalization and new methods for their identification. Compounds of this invention include modified phosphoinositide 3-kinase (PI3K), modified HEAT domain, modified β-adrenergic receptor kinase 1 (βARK1), as well as other peptides or small molecules that alter GPCR internalization. The present invention also includes the use of such compounds to treat GPCR-related diseases, such as cardiovascular disease, heart failure, asthma, nephrogenic diabetes insipidus, or hypertension.

公开(公告)号：US06610532B2

公开(公告)日：2003-08-26

申请号：US09121814

申请日：1998-07-24

申请人： Walter J. Koch ,  Robert J. Lefkowitz ,  Shahab A. Akhter ,  Louis M. Luttrell ,  Howard Rockman

发明人： Walter J. Koch ,  Robert J. Lefkowitz ,  Shahab A. Akhter ,  Louis M. Luttrell ,  Howard Rockman

IPC分类号： A61K4800

CPC分类号： C07K14/4722 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0375 ,  A61K38/00 ,  A61K48/00 ,  C12N15/8509 ,  C12N2830/008

摘要： The present invention relates, in general, to myocardial hypertrophy and, in particular, to agents that inhibit cardiac Gq-coupled receptor signaling and to methods of inhibiting myocardial hypertrophy using same.