公开(公告)号：US11999770B2

公开(公告)日：2024-06-04

申请号：US17134977

申请日：2020-12-28

申请人： University of Bradford

发明人： Mohamed El-Tanani ,  Paul McCarron ,  Ahmed Faheem

IPC分类号： C07K14/47 ,  A61K9/51 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K38/00

CPC分类号： C07K14/4703 ,  A61K9/51 ,  A61K9/5153 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4722 ,  A61K9/5146 ,  A61K38/00 ,  G01N2500/02

摘要： The present invention relates to peptides, methods for production of the same, nanoparticle formulations of the same and the use of these new peptides and nanoparticle formulations as inhibitors of protein-protein interactions, in particular for application in the treatment of diseases associated with overexpression of the RAN gene.

公开(公告)号：US10011634B2

公开(公告)日：2018-07-03

申请号：US14843152

申请日：2015-09-02

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Xiaoping Du

IPC分类号： C07K7/06 ,  A61K38/08 ,  C07K14/47 ,  C07K14/705 ,  A61K47/69 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  A61K47/6909 ,  A61K2039/505 ,  C07K14/4722 ,  C07K14/70546 ,  C07K14/70557

摘要： Provided herein are compounds that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.

公开(公告)号：US20180147252A1

公开(公告)日：2018-05-31

申请号：US15862535

申请日：2018-01-04

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Daria Mochly-Rosen ,  Xin Qi ,  Nir Qvit

IPC分类号： A61K38/08 ,  A61K38/16 ,  C12Q1/34 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/47 ,  C12N9/14 ,  G01N33/573 ,  C07K14/00 ,  A61K51/08 ,  A61K38/00

CPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/16 ,  A61K51/08 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4722 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/14 ,  C12Q1/34 ,  G01N33/573 ,  G01N2333/4703 ,  G01N2333/914 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on binding of dynamin-1-related protein (Drp1) GTPase activity, Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.

公开(公告)号：US20160152676A1

公开(公告)日：2016-06-02

申请号：US14936200

申请日：2015-11-09

申请人： COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Brian R. McNaughton ,  Susanne N. Walker ,  Racel L. Tennyson ,  Alan J. Kennan

IPC分类号： C07K14/47 ,  C12N7/00 ,  C07K14/005

CPC分类号： C07K14/4722 ,  A61K38/00 ,  C07K14/005 ,  C07K2319/33 ,  C12N2740/16033 ,  C12N2740/16122

摘要： The disclosure provides helix grafted proteins, methods of producing helix grafted proteins and methods of use of helix grafted proteins as inhibitors of protein-protein interactions involved in disease pathogenesis.

摘要翻译： 本公开提供螺旋移植蛋白，生产螺旋移植蛋白的方法和使用螺旋移植蛋白作为参与疾病发病的蛋白质 - 蛋白质相互作用的抑制剂的方法。

公开(公告)号：US20150306248A1

公开(公告)日：2015-10-29

申请号：US14695265

申请日：2015-04-24

申请人： Sujata Acharjee

发明人： Sujata Acharjee

IPC分类号： A61K48/00 ,  C07K14/435 ,  C12N9/22 ,  C07K14/005

CPC分类号： A61K48/0008 ,  C07K14/005 ,  C07K14/435 ,  C07K14/4722 ,  C07K2319/01 ,  C07K2319/80 ,  C07K2319/85 ,  C12N9/22 ,  C12N15/87 ,  C12N2760/20222

摘要： The design and generation of a number of chimeric VSV-G (or VSV-G variants) proteins are used as transfer vehicles to enhance delivery of nucleic acids like plasmid DNA, single and double stranded DNA and RNA, and antisense oligonucleotides into human and animal cells. These chimeric VSV-G protein-nucleic acid transfer vehicles have widespread applications to deliver nucleic acids for exon skipping and gene delivery for gene replacement in human and animals.

摘要翻译： 使用许多嵌合VSV-G（或VSV-G变体）蛋白质的设计和生成作为转运载体来增强核酸如质粒DNA，单链和双链DNA和RNA以及反义寡核苷酸向人和动物的递送 细胞。 这些嵌合VSV-G蛋白 - 核酸转运载体在人和动物中具有用于递送核酸用于外显子跳过和基因递送用于基因替换的广泛应用。

公开(公告)号：US20130315934A1

公开(公告)日：2013-11-28

申请号：US13881623

申请日：2011-10-28

申请人： Ruth Halaban ,  Michael Krauthammer ,  Joseph Schlessinger ,  Titus J. Boggon

发明人： Ruth Halaban ,  Michael Krauthammer ,  Joseph Schlessinger ,  Titus J. Boggon

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C07K14/4722 ,  C12N9/14 ,  G01N33/5743 ,  G01N2333/82 ,  G01N2800/52

摘要： The invention relates to methods and compositions for identifying mutations associated with cancer, such as melanoma. More particularly, the invention relates to methods and compositions for assessing particular mutations as markers for cancer, such as melanoma. Such methods and compositions allow medical providers to diagnose cancer, such as melanoma, based upon the presence of one or more particular mutations in a subject, as compared with an otherwise healthy control. The methods and compositions are also useful in guiding the type of therapy to be applied, and monitoring the effects of the therapy applied.

摘要翻译： 本发明涉及用于鉴定与癌症相关的突变的方法和组合物，例如黑素瘤。 更具体地，本发明涉及用于评估特定突变作为癌症标志物的方法和组合物，例如黑素瘤。 与其他健康对照相比，这样的方法和组合物允许医疗提供者基于受试者中一种或多种特定突变的存在来诊断癌症，例如黑素瘤。 方法和组合物也可用于指导所应用的治疗类型，并监测所施用的治疗效果。

公开(公告)号：US20120065139A1

公开(公告)日：2012-03-15

申请号：US13058836

申请日：2008-08-11

申请人： Xiaohui LI ,  Haigang Zhang ,  Jianzhi Zhou ,  Shuhui Li

发明人： Xiaohui LI ,  Haigang Zhang ,  Jianzhi Zhou ,  Shuhui Li

IPC分类号： A61K38/17 ,  C07K7/08 ,  A61P9/00 ,  C07K1/00 ,  C12P21/02 ,  C07K14/47 ,  A61K38/10

CPC分类号： C07K14/4722 ,  A61K38/00 ,  C07K14/47

摘要： Provided are a series of Gq protein competitive inhibitory polypeptides (GCIPs), polynucleotides encoding them, and preparation methods thereof. Also provided are pharmaceutical compositions comprising GCIP polypeptides and their uses in the manufacture of drugs for treating myocardial hypertrophy.

摘要翻译： 提供了一系列Gq蛋白竞争性抑制多肽（GCIP），编码它们的多核苷酸及其制备方法。 还提供了包含GCIP多肽的药物组合物及其在制备用于治疗心肌肥大的药物中的用途。

公开(公告)号：US07893203B2

公开(公告)日：2011-02-22

申请号：US12118247

申请日：2008-05-09

申请人： Yasuhiko Takahashi ,  Yasuo Matsumoto ,  Kenji Oeda

发明人： Yasuhiko Takahashi ,  Yasuo Matsumoto ,  Kenji Oeda

IPC分类号： C07K14/47

CPC分类号： C07K14/4722

摘要： A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein α subunits and a trimer forming domain conserved among G protein α subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. A method for screening for a substance capable of regulating a cellular signal transduction employs a polynucleotide encoding the Gm1 protein.

摘要翻译： 一种新型蛋白质（Gm1）包括与G蛋白α亚基保守的G蛋白α亚基和三聚体形成结构域在G蛋白α亚基中保守的与GTP结合位点和GTP酶位点高度同源的结构域具有高度同源性的氨基酸序列部分。 Gm1蛋白通过G蛋白偶联受体（GPCR）刺激参与信号转导。 Gm1蛋白在人脑，胸腺，睾丸，脾脏，小肠，子宫和心脏中都集中表达。 筛选能够调节细胞信号转导的物质的方法采用编码Gm1蛋白的多核苷酸。

公开(公告)号：US07649088B2

公开(公告)日：2010-01-19

申请号：US11523305

申请日：2006-09-19

申请人： John K. Fink ,  Xinping Zhao

发明人： John K. Fink ,  Xinping Zhao

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4722 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893

摘要： The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment of these disabling diseases.

摘要翻译： 本发明涉及新基因的方法和组合以及由该基因编码的肽。 基因突变，命名为atlastin，是疾病中的因素遗传性痉挛性截瘫及相关疾病。 本发明将用于研究，诊断和治疗这些致残性疾病。

公开(公告)号：US20090137501A1

公开(公告)日：2009-05-28

申请号：US11793575

申请日：2005-12-28

申请人： Masaaki Miyazawa ,  Shinji Irie ,  Mario Clerici

发明人： Masaaki Miyazawa ,  Shinji Irie ,  Mario Clerici

IPC分类号： A61K31/711 ,  C12Q1/68 ,  A61P31/18 ,  C07K16/18

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/4705 ,  C07K14/4722 ,  C07K14/4747 ,  C07K14/4753 ,  C07K14/52 ,  C12N9/1205 ,  C12N9/78 ,  C12Q1/703 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： Genes involved in immune resistance to infection and uses thereof are described. In particular genes which are involved in resistance to HIV infection and in slowing disease progression in infected individuals are described.

摘要翻译： 描述了涉及免疫抵抗感染的基因及其用途。 具体描述了涉及HIV感染的抗性和感染个体中疾病进展缓慢的基因。