公开(公告)号：US20070167724A1

公开(公告)日：2007-07-19

申请号：US11298876

申请日：2005-12-09

申请人： Hrishikesh Gadagkar ,  Catherine Elsinger ,  Stephanie Sylve ,  Stephen Rao

发明人： Hrishikesh Gadagkar ,  Catherine Elsinger ,  Stephanie Sylve ,  Stephen Rao

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  G01R33/4806 ,  G01R33/546

摘要： A data acquisition system for use in conducting functional magnetic resonance imaging studies. fMRI studies can provide clues to the neurobiological basis of CNS disorders and reliable and quantifiable data relating to their symptoms. The data acquisition system includes a control station, a patient stimulus and response system and fMRI data acquisition software for controlling the operation of the system in response to operator input and acquiring fMRI data comprising MR images and associated behavioral response data. The stimulus and response system presents visual or auditory or other stimuli to the patient under direction of the control station while functional MRI scanning takes place. The MRI image data is collected from the MRI scanner and combined with the behavioral data generated as the patient responds to the stimuli and archived for later analysis and use. The system includes quality control measures for properly setting up the equipment and preparing and training the patient and for verifying data quality during the different steps in the process.

摘要翻译： 用于进行功能磁共振成像研究的数据采集系统。 功能磁共振成像研究可以为CNS疾病的神经生物学基础提供线索，并提供与其症状有关的可靠且可量化的数据。 数据采集​​系统包括控制站，患者刺激和响应系统以及fMRI数据采集软件，用于响应于操作员输入控制系统的操作并获取包括MR图像和相关行为响应数据的fMRI数据。 刺激和反应系统在进行功能性MRI扫描时向控制站的指导下呈现视觉或听觉或其他刺激。 从MRI扫描仪收集MRI图像数据，并结合当患者对刺激进行响应时生成的行为数据，并存档以供以后分析和使用。 该系统包括正确设置设备，准备和培训患者的质量控制措施，以及在过程中的不同步骤中验证数据质量。

公开(公告)号：US20050267357A1

公开(公告)日：2005-12-01

申请号：US11179167

申请日：2005-07-12

申请人： Stephen Rao ,  Catherine Elsinger

发明人： Stephen Rao ,  Catherine Elsinger

IPC分类号： A61B5/055 ,  G01N33/68 ,  G06F19/00 ,  A61B5/05

CPC分类号： A61B5/055 ,  A61B5/168 ,  A61B5/4064 ,  G01N33/6896 ,  G16H10/20

摘要： A system based on the use of fMRI techniques for use in detecting neurological abnormalities indicative of Attention Deficit Hyperactivity Disorder (ADHD), in determining the severity of ADHD and in gauging the efficacy of medications used in treating ADHD. The system includes the steps of activating a selected region of the brain which is known to be affected by ADHD using a working memory and sustained attention task such as an N-Back task and concurrently acquiring fMRI image data responsive to the task. The patient's task-active fMRI data is then compared to reference fMRI data derived from a database of task-active fMRI data acquired from healthy individuals and determining whether the patient has symptoms related to ADHD. The extent of the patient's ADHD related symptoms and the severity of the disorder may also be assessed. Additionally, patients who are affected by ADHD may be administered medications intended to address their symptoms and based on comparing the severity of the patient's symptoms on and off therapy, the efficiency of the medication may be gauged and a measure may be provided of how well individual patients respond to a given medication.

摘要翻译： 基于使用fMRI技术用于检测指示缺陷多动障碍（ADHD）的神经系统异常的系统，用于确定ADHD的严重程度和衡量用于治疗ADHD的药物的功效。 该系统包括以下步骤：利用工作记忆和持续关注任务（例如N-Back任务）激活已知受ADHD影响的大脑的选定区域，以及响应于该任务同时获取fMRI图像数据。 然后将患者的任务活动的fMRI数据与从从健康个体获得的任务活动的fMRI数据的数据库导出的参考fMRI数据进行比较并确定患者是否具有与ADHD相关的症状。 也可以评估患者ADHD相关症状的程度和病情的严重程度。 另外，受ADHD影响的患者可能会被给予旨在解决其症状的药物，并且基于对患者症状的严重程度进行治疗和比较，可以测量药物的效率，并且可以提供个体的程度 患者对给定的药物作出反应。

公开(公告)号：US20050197560A1

公开(公告)日：2005-09-08

申请号：US10793994

申请日：2004-03-05

申请人： Stephen Rao ,  Catherine Elsinger

发明人： Stephen Rao ,  Catherine Elsinger

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/4088 ,  G01R33/4806

摘要： A system for using functional magnetic resonance imaging (fMRI) for detecting symptoms indicative of Alzheimer's disease, diagnosing Alzheimer's disease and gauging the efficacy of medications used in treating Alzheimer's disease. The system includes steps involving activating a selected region of the brain which may be affected by Alzheimer's disease using an identity recognition type task, concurrently acquiring task-active MRI data responsive to the task, comparing the patient's task-active MRI data to reference data derived from a database of task-active data from healthy individuals and detecting whether the patient has symptoms related to Alzheimer's disease. The severity of the patient's symptoms and the staging of the disease may also be determined. Also, a medication may be administered to the patient and the efficacy of the medication may be gauged based on the severity of the patient's symptoms.

摘要翻译： 一种使用功能磁共振成像（fMRI）检测表征阿尔茨海默病的症状，诊断阿尔茨海默病和测量用于治疗阿尔茨海默病的药物疗效的系统。 该系统包括使用身份识别类型任务激活可能受阿尔茨海默病影响的脑的选定区域的步骤，同时获取响应于该任务的任务活动MRI数据，将患者的任务活动MRI数据与导出的参考数据进行比较 来自健康个体的任务活动数据的数据库，并检测患者是否具有与阿尔茨海默病有关的症状。 也可以确定患者症状的严重程度和疾病的分期。 此外，可以向患者施用药物，并且可以基于患者症状的严重性来测量药物的功效。

公开(公告)号：US20050197561A1

公开(公告)日：2005-09-08

申请号：US10793995

申请日：2004-03-05

申请人： Catherine Elsinger ,  Stephen Rao

发明人： Catherine Elsinger ,  Stephen Rao

IPC分类号： A61B5/05 ,  A61B5/055 ,  G01R33/48

CPC分类号： A61B5/055 ,  A61B5/4064 ,  A61B5/4082 ,  G01R33/4806

摘要： A system for using functional magnetic resonance imaging (fMRI) for detecting symptoms indicative of Parkinson's disease, diagnosing Parkinson's disease and gauging the efficacy of medications used in treating Parkinson's disease. The system includes process steps involving activating a selected region of the brain which may be affected by Parkinson's disease using a delayed response motor sequence type task, concurrently acquiring task-active MRI data responsive to the task, comparing the patient's task-active MRI data to reference data derived from a database of task-active data from healthy individuals and detecting whether the patient has symptoms related to Parkinson's disease. The severity of the patient's symptoms and the staging of the disease may also be determined. Also, a medication may be administered to the patient and the efficacy of the medication may gauged based on the severity of the patient's symptoms on and off of medication.

摘要翻译： 一种使用功能磁共振成像（fMRI）来检测指示帕金森病的症状，诊断帕金森病并测量用于治疗帕金森病的药物疗效的系统。 该系统包括使用延迟响应运动序列类型任务激活可能受帕金森病影响的脑的选定区域的过程步骤，同时获取响应于该任务的任务活动MRI数据，将患者的任务活动MRI数据与 来自健康个体的任务活动数据的数据库的参考数据，并检测患者是否存在与帕金森病相关的症状。 也可以确定患者症状的严重程度和疾病的分期。 此外，可以向患者施用药物，并且可以基于患者的药物的症状的严重程度来测量药物的功效。

公开(公告)号：US20050107682A1

公开(公告)日：2005-05-19

申请号：US10971289

申请日：2004-10-21

申请人： Stephen Rao ,  Catherine Elsinger

发明人： Stephen Rao ,  Catherine Elsinger

IPC分类号： A61B5/055 ,  A61B5/05

CPC分类号： A61B5/055 ,  A61B5/4064 ,  A61B5/4088

摘要： A system for assessing the medical effectiveness of therapies such as pharmaceutical medications for use in treating central nervous system disorders. Functional magnetic resonance imaging techniques are utilized in measuring neural activity induced by specific activation tasks in specific regions of the brain that are known to be affected by a central nervous system disorder. The levels of neural activity induced in patients subject to the disorder when on and off of the therapy are compared and then compared with normative data generated with respect to healthy individuals under comparable conditions. These comparisons quantify and assess the efficacy of the therapy.

摘要翻译： 用于评估用于治疗中枢神经系统疾病的药物治疗药物疗效的系统。 功能磁共振成像技术用于测量由已知受中枢神经系统疾病影响的特定区域的特定活化任务诱导的神经活动。 比较在治疗期间患有疾病的患者中诱导的神经活动水平，然后与在可比较的条件下对健康个体生成的规范数据进行比较。 这些比较量化和评估治疗的功效。

公开(公告)号：US20050085705A1

公开(公告)日：2005-04-21

申请号：US10970927

申请日：2004-10-21

申请人： Stephen Rao ,  Catherine Elsinger

发明人： Stephen Rao ,  Catherine Elsinger

IPC分类号： A61B5/055 ,  G01N33/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50 ,  A61B5/05

CPC分类号： G01N33/6896 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4088 ,  G16H10/20

摘要： A system for detecting neural abnormalities associated with specific central nervous system disorders in patients suspected of suffering from said disorders and for assisting in assessing the staging of said disorders in patients suffering from said disorders. Magnetic resonance imaging (MRI) machines and functional magnetic resonance imaging (fMRI) techniques are used to generate fMRI time series image data with respect to a selected regions of interest in the brain known to be affected by given disorders in response to activation tasks known to induce neural activity specifically in these regions. The fMRI data is used in generating statistically based standards and profiles by which abnormalities can be identified and the staging of disorders can be assessed. The results are diagrammatically or graphically displayed so that the data, standards and profiles can be usefully compared.

摘要翻译： 一种用于检测涉嫌患有所述病症的患者中与特定中枢神经系统疾病相关的神经异常并用于协助评估患有所述疾病的患者所述疾病的分期的系统。 使用磁共振成像（MRI）机器和功能性磁共振成像（fMRI）技术来产生关于已知受给定障碍影响的选定感兴趣的区域的fMRI时间序列图像数据，以响应已知的激活任务 在这些区域特异性诱导神经活动。 fMRI数据用于产生基于统计学的标准和分布，通过其可以识别异常，并且可以评估疾病分期。 结果以图形方式或图形显示，以便可以有效地比较数据，标准和配置文件。