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公开(公告)号：US08226928B1
公开(公告)日：2012-07-24
申请号：US13434800
申请日：2012-03-29
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Ha Giang Thi Nguyen , Fang Yi Su , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Ha Giang Thi Nguyen , Fang Yi Su , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55 , A61K47/593 , A61K47/61
摘要： The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein the bioactive agent may include mitofusin 1, mitofusin 2, and/or anti-diabetic compounds.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种生物活性剂组成的纳米颗粒，其中生物活性剂可包括mitofusin 1，mitofusin 2和/或抗糖尿病化合物。
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公开(公告)号：US08287905B1
公开(公告)日：2012-10-16
申请号：US13438764
申请日：2012-04-03
申请人： Hsing-Wen Sung , Er-Yuan Chuang , Ha Giang Thi Nguyen , Fang Yi Su , Kiran Sonaje , Hosheng Tu
发明人： Hsing-Wen Sung , Er-Yuan Chuang , Ha Giang Thi Nguyen , Fang Yi Su , Kiran Sonaje , Hosheng Tu
IPC分类号： A61K9/66
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K38/00 , A61K47/6935 , A61K47/6939
摘要： The invention discloses a composition of chitosan-shelled nanoparticles and methods of manufacturing. The chitosan-shelled nanoparticles are characterized with a positive surface charge and enhanced epithelial permeability for oral drug delivery.
摘要翻译： 本发明公开了一种壳聚糖壳形纳米颗粒的组成及其制造方法。 壳聚糖壳的纳米粒子的特征在于具有正的表面电荷和增强的口服药物递送的上皮通透性。
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公开(公告)号：US08354094B1
公开(公告)日：2013-01-15
申请号：US13589618
申请日：2012-08-20
申请人： Hsing-Wen Sung , Kiran Sonaje , Zi-Xian Liao , Ha Giang Thi Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Zi-Xian Liao , Ha Giang Thi Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
摘要翻译： 本发明公开了一种由壳聚糖，聚谷氨酸和用于口服递送的生物活性剂组成的生物活性纳米粒子的药物组合物。 基于壳聚糖的纳米颗粒的特征在于具有正的表面电荷和增强的口服药物递送的渗透性。
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公开(公告)号：US08361439B1
公开(公告)日：2013-01-29
申请号：US13589934
申请日：2012-08-20
申请人： Hsing-Wen Sung , Kiran Sonaje , Zi-Xian Liao , Ha Giang Thi Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Zi-Xian Liao , Ha Giang Thi Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
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公开(公告)号：US08221795B1
公开(公告)日：2012-07-17
申请号：US13374046
申请日：2011-12-08
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5161 , A61K9/5169 , A61K31/445 , A61K31/55 , A61K49/1881
摘要： The invention relates to a method of managing a tumor of an animal subject comprising imaging the tumor by delivering a dosage of imaging nanoparticles to the tumor site, the imaging nanoparticles consisting of positively charged chitosan, optionally a zero-charge substance or bioactive agent, and a negatively charged substrate having gadolinium (Gd) chelated to the negatively charged substrate.
摘要翻译： 本发明涉及一种管理动物受试者的肿瘤的方法，包括通过将剂量的成像纳米颗粒递送到肿瘤部位来成像肿瘤，由正电荷的壳聚糖，任选的零电荷物质或生物活性剂组成的成像纳米颗粒，以及 具有与带负电的基底螯合的钆（Gd）的带负电荷的衬底。
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公开(公告)号：US08192718B1
公开(公告)日：2012-06-05
申请号：US13373995
申请日：2011-12-07
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55 , A61K47/645
摘要： The invention relates to a method for treating disorders or diseases of a tight junction comprising delivering a pharmaceutical composition of nanoparticles to the tight junction, wherein the nanoparticles consist of positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating said disorders or diseases of the tight junction of an animal subject.
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公开(公告)号：US08349799B1
公开(公告)日：2013-01-08
申请号：US13525307
申请日：2012-06-16
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K38/00
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for drug delivery.
摘要翻译： 本发明公开了一种由壳聚糖，聚谷氨酸和用于口服递送的生物活性剂组成的生物活性纳米粒子的药物组合物。 基于壳聚糖的纳米颗粒的特征在于具有正的表面电荷并增加药物递送的渗透性。
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公开(公告)号：US08337811B1
公开(公告)日：2012-12-25
申请号：US13418299
申请日：2012-03-12
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
摘要翻译： 本发明公开了一种由壳聚糖，聚谷氨酸和用于口服递送的生物活性剂组成的生物活性纳米粒子的药物组合物。 基于壳聚糖的纳米颗粒的特征在于具有正的表面电荷和增强的口服药物递送的渗透性。
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公开(公告)号：US08202839B1
公开(公告)日：2012-06-19
申请号：US13374675
申请日：2012-01-07
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K38/00
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
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公开(公告)号：US20120207845A1
公开(公告)日：2012-08-16
申请号：US13453149
申请日：2012-04-23
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K9/14 , A61K31/573 , A61K31/52 , A61K31/519 , A61K31/7048 , A61K31/496 , A61K31/4196 , A61K38/28 , A61P25/08 , A61P29/00 , A61P39/06 , A61P31/10 , A61P25/00 , A61P25/28 , A61P3/10 , A61K31/196 , B82Y5/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55 , A61K47/645
摘要： The invention relates to a method for treating disorders or diseases of a tight junction comprising delivering a pharmaceutical composition of nanoparticles to the tight junction, wherein the nanoparticles consist of positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating said disorders or diseases of the tight junction of an animal subject.
摘要翻译： 本发明涉及用于治疗紧密连接的疾病或疾病的方法，包括将纳米颗粒的药物组合物递送到紧密连接处，其中纳米颗粒由带正电荷的壳聚糖，带负电荷的底物，任选的零电荷化合物组成， 至少一种用于治疗动物受试者紧密连接的疾病或疾病的生物活性剂。
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