公开(公告)号：US20080138339A1

公开(公告)日：2008-06-12

申请号：US11895207

申请日：2007-08-22

申请人： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Jie Feng ,  Ping Zhou ,  Xiaocong Yu ,  Qing Lin

发明人： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Jie Feng ,  Ping Zhou ,  Xiaocong Yu ,  Qing Lin

IPC分类号： A61K39/395 ,  C12N15/11 ,  C07K16/18 ,  A61P43/00 ,  C12N15/00 ,  C12N1/20

CPC分类号： C07K16/2809 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.

摘要翻译： 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。

公开(公告)号：US07262276B2

公开(公告)日：2007-08-28

申请号：US10478345

申请日：2002-05-23

申请人： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Xiaocong Yu ,  Jie Feng ,  Ping Zhou ,  Qing Lin

发明人： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Xiaocong Yu ,  Jie Feng ,  Ping Zhou ,  Qing Lin

IPC分类号： C07K16/30

CPC分类号： C07K16/2809 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.

摘要翻译： 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。

公开(公告)号：US20050255115A1

公开(公告)日：2005-11-17

申请号：US10478345

申请日：2002-05-23

申请人： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Jie Feng ,  Ping Zhou ,  Xiaocong Yu ,  Qing Lin

发明人： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Jie Feng ,  Ping Zhou ,  Xiaocong Yu ,  Qing Lin

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  C12N15/13 ,  C12N15/62 ,  C12N15/63 ,  C12P21/08 ,  G01N33/574 ,  C12N5/06

CPC分类号： C07K16/2809 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.

摘要翻译： 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。