公开(公告)号：US08916607B2

公开(公告)日：2014-12-23

申请号：US13498272

申请日：2009-10-20

申请人： Huayin Wan ,  Rubing Li ,  Lijian Zhou ,  Tieqiu Liu ,  Yangshu Chen ,  Yonghe Li

发明人： Huayin Wan ,  Rubing Li ,  Lijian Zhou ,  Tieqiu Liu ,  Yangshu Chen ,  Yonghe Li

IPC分类号： A61K31/335 ,  A61K31/36 ,  A61K31/357

CPC分类号： A61K31/36 ,  A61K31/357

摘要： The present invention relates to the use of piperphentonamine or pharmaceutically acceptable salts thereof to prevent/treat encephalopathy in mammals, and the use of a combination of piperphentonamine or pharmaceutically acceptable salts thereof and other medicines in manufacture a medicine to prevent/treat encephalopathy in mammals. The mammals include human beings, and the encephalopathy includes cerebral injury related diseases or cerebrovascular diseases. The cerebrovascular diseases refer to cerebral ischemia, cerebral ischemia/reperfusion-induced injury or cerebral hemorrhage. The cerebral hemorrhage includes hypertensive cerebral hemorrhage, cerebral hemorrhage secondary to infarction, tumor cerebral hemorrhage or cerebral hemorrhage caused by arteritis. The cerebral ischemia means carotid system cerebral ischemia or vertebrobasilar cerebral ischemia.

摘要翻译： 本发明涉及哌酚苯胺或其药学上可接受的盐在哺乳动物中预防/治疗脑病的用途，以及在制备用于预防/治疗哺乳动物中的脑病的药物中使用胡椒胺或其药学上可接受的盐与其它药物的组合的用途。 哺乳动物包括人类，脑病包括脑损伤相关疾病或脑血管疾病。 脑血管疾病是指脑缺血，脑缺血/再灌注损伤或脑出血。 脑出血包括高血压性脑出血，继发于脑梗塞的脑出血，脑出血，脑动脉炎引起的脑出血。 脑缺血是指颈动脉系脑缺血或椎基底动脉脑缺血。