公开(公告)号：US08916607B2

公开(公告)日：2014-12-23

申请号：US13498272

申请日：2009-10-20

申请人： Huayin Wan ,  Rubing Li ,  Lijian Zhou ,  Tieqiu Liu ,  Yangshu Chen ,  Yonghe Li

发明人： Huayin Wan ,  Rubing Li ,  Lijian Zhou ,  Tieqiu Liu ,  Yangshu Chen ,  Yonghe Li

IPC分类号： A61K31/335 ,  A61K31/36 ,  A61K31/357

CPC分类号： A61K31/36 ,  A61K31/357

摘要： The present invention relates to the use of piperphentonamine or pharmaceutically acceptable salts thereof to prevent/treat encephalopathy in mammals, and the use of a combination of piperphentonamine or pharmaceutically acceptable salts thereof and other medicines in manufacture a medicine to prevent/treat encephalopathy in mammals. The mammals include human beings, and the encephalopathy includes cerebral injury related diseases or cerebrovascular diseases. The cerebrovascular diseases refer to cerebral ischemia, cerebral ischemia/reperfusion-induced injury or cerebral hemorrhage. The cerebral hemorrhage includes hypertensive cerebral hemorrhage, cerebral hemorrhage secondary to infarction, tumor cerebral hemorrhage or cerebral hemorrhage caused by arteritis. The cerebral ischemia means carotid system cerebral ischemia or vertebrobasilar cerebral ischemia.

摘要翻译： 本发明涉及哌酚苯胺或其药学上可接受的盐在哺乳动物中预防/治疗脑病的用途，以及在制备用于预防/治疗哺乳动物中的脑病的药物中使用胡椒胺或其药学上可接受的盐与其它药物的组合的用途。 哺乳动物包括人类，脑病包括脑损伤相关疾病或脑血管疾病。 脑血管疾病是指脑缺血，脑缺血/再灌注损伤或脑出血。 脑出血包括高血压性脑出血，继发于脑梗塞的脑出血，脑出血，脑动脉炎引起的脑出血。 脑缺血是指颈动脉系脑缺血或椎基底动脉脑缺血。

公开(公告)号：US20100197731A1

公开(公告)日：2010-08-05

申请号：US12598356

申请日：2007-01-31

申请人： Huayin Wan ,  Rubing Li ,  Yonghe Li ,  Lijian Zhou ,  Tieqiu Liu ,  Xiaohui Zhong

发明人： Huayin Wan ,  Rubing Li ,  Yonghe Li ,  Lijian Zhou ,  Tieqiu Liu ,  Xiaohui Zhong

IPC分类号： A61K31/445 ,  A61P9/00

CPC分类号： A61K31/36 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07D317/48

摘要： A kind of piperphentonamine hydrochloride lyophilized powder for injection and a preparation method thereof. The injection is prepared by one portion of piperphentonamine hydrochloride, 2.5-30 parts of excipient and 400-600 parts of water for injection with pH 1.5-5.5 via freeze-drying. The excipient is mannitol, dextran, lactose, saccharose, polyethylene glycol, poloxamer, glycine, etc.; It is preferred that the injection comprises one part of piperphentonamine hydrochloride, 10 parts of mannitol and 500 parts of water for injection with pH 2.0-3.0. The product is prepared by adding said piperphentonamine hydrochloride and excipient into water for injection, heating at 40° C.-90° C., ultrasonic dissolving, degerming, individually packing, pre-freezing and multistage drying, and packaging. Individually packing into a tubular glass bottle with brown color is preferred. The appearance, color & luster and solubility of the injection are excellent, the stability is good and with long storage period. The invention also provides the uses of the injection in the preparation of a medicament for treatment of heart failure and/or cardioprotection.

摘要翻译： 一种盐酸椒苯酮胺冻干粉末及其制备方法。 注射液由盐酸椒苯酮胺，2.5-30份赋形剂和400-600份注射用水通过冷冻干燥制备，pH为1.5-5.5。 赋形剂是甘露糖醇，葡聚糖，乳糖，蔗糖，聚乙二醇，泊洛沙姆，甘氨酸等; 注射剂优选包含一部分盐酸椒苯酮胺，10份甘露醇和500份注射用水，pH为2.0-3.0。 通过将所述盐酸椒苯酮胺和赋形剂加入注射用水中，在40℃〜90℃加热，超声溶解，除菌，单独包装，预冷冻和多级干燥以及包装，制备产品。 单独包装成棕色的管状玻璃瓶是首选。 注射剂的外观，颜色，光泽和溶解性优异，稳定性好，储存时间长。 本发明还提供了注射用于制备用于治疗心力衰竭和/或心脏保护的药物的用途。

公开(公告)号：US08513301B2

公开(公告)日：2013-08-20

申请号：US12598356

申请日：2007-01-31

申请人： Huayin Wan ,  Rubing Li ,  Yonghe Li ,  Lijian Zhou ,  Tieqiu Liu ,  Xiaohui Zhong

发明人： Huayin Wan ,  Rubing Li ,  Yonghe Li ,  Lijian Zhou ,  Tieqiu Liu ,  Xiaohui Zhong

IPC分类号： A61K31/36 ,  A61K31/445 ,  A61K9/00

CPC分类号： A61K31/36 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07D317/48

摘要： A kind of piperphentonamine hydrochloride lyophilized powder for injection and a preparation method thereof. The injection is prepared by one portion of piperphentonamine hydrochloride, 2.5-30 parts of excipient and 400-600 parts of water for injection with pH 1.5-5.5 via freeze-drying. The excipient is mannitol, dextran, lactose, saccharose, polyethylene glycol, poloxamer, glycine, etc.; It is preferred that the injection comprises one part of piperphentonamine hydrochloride, 10 parts of mannitol and 500 parts of water for injection with pH 2.0-3.0. The product is prepared by adding said piperphentonamine hydrochloride and excipient into water for injection, heating at 40° C.-90° C., ultrasonic dissolving, degerming, individually packing, pre-freezing and multistage drying, and packaging. Individually packing into a tubular glass bottle with brown color is preferred. The appearance, color & luster and solubility of the injection are excellent, the stability is good and with long storage period. The invention also provides the uses of the injection in the preparation of a medicament for treatment of heart failure and/or cardioprotection.

摘要翻译： 一种盐酸椒苯酮胺冻干粉末及其制备方法。 注射液由盐酸椒苯酮胺，2.5-30份赋形剂和400-600份注射用水通过冷冻干燥制备，pH为1.5-5.5。 赋形剂是甘露糖醇，葡聚糖，乳糖，蔗糖，聚乙二醇，泊洛沙姆，甘氨酸等; 注射剂优选包含一部分盐酸椒苯酮胺，10份甘露醇和500份注射用水，pH为2.0-3.0。 通过将所述盐酸椒苯酮胺和赋形剂加入注射用水中，在40℃〜90℃加热，超声溶解，除菌，单独包装，预冷冻和多级干燥以及包装，制备产品。 单独包装成棕色的管状玻璃瓶是首选。 注射剂的外观，颜色，光泽和溶解性优异，稳定性好，储存时间长。 本发明还提供了注射用于制备用于治疗心力衰竭和/或心脏保护的药物的用途。

公开(公告)号：US20120184607A1

公开(公告)日：2012-07-19

申请号：US13498272

申请日：2009-10-20

申请人： Huayin Wan ,  Rubing Li ,  Lijian Zhou ,  Tieqiu Liu ,  Yanshu Chen ,  Yonghe Li

发明人： Huayin Wan ,  Rubing Li ,  Lijian Zhou ,  Tieqiu Liu ,  Yanshu Chen ,  Yonghe Li

IPC分类号： A61K31/36 ,  A61P9/10 ,  A61P9/00 ,  C07D317/58 ,  A61P25/00

CPC分类号： A61K31/36 ,  A61K31/357

摘要： The present invention relates to the use of piperphentonamine or pharmaceutically acceptable salts thereof to prevent/treat encephalopathy in mammals, and the use of a combination of piperphentonamine or pharmaceutically acceptable salts thereof and other medicines in manufacture a medicine to prevent/treat encephalopathy in mammals. The mammals include human beings, and the encephalopathy includes cerebral injury related diseases or cerebrovascular diseases. The cerebrovascular diseases refer to cerebral ischemia, cerebral ischemia/reperfusion-induced injury or cerebral hemorrhage. The cerebral hemorrhage includes hypertensive cerebral hemorrhage, cerebral hemorrhage secondary to infarction, tumor cerebral hemorrhage or cerebral hemorrhage caused by arteritis. The cerebral ischemia means carotid system cerebral ischemia or vertebrobasilar cerebral ischemia.

摘要翻译： 本发明涉及哌酚苯胺或其药学上可接受的盐在哺乳动物中预防/治疗脑病的用途，以及在制备用于预防/治疗哺乳动物中的脑病的药物中使用胡椒胺或其药学上可接受的盐与其它药物的组合的用途。 哺乳动物包括人类，脑病包括脑损伤相关疾病或脑血管疾病。 脑血管疾病是指脑缺血，脑缺血/再灌注损伤或脑出血。 脑出血包括高血压性脑出血，继发于脑梗塞的脑出血，脑出血，脑动脉炎引起的脑出血。 脑缺血是指颈动脉系脑缺血或椎基底动脉脑缺血。