公开(公告)号：US08197470B2

公开(公告)日：2012-06-12

申请号：US12197104

申请日：2008-08-22

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61B18/18

CPC分类号： A61B18/04 ,  A61B2017/3425 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2018/00005 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/048

摘要： A method and system of providing therapy to a patient's uterus. The method include the following steps: inserting an access tool through a cervix and a cervical canal into the uterus; after inserting the access tool into the uterus, inserting a vapor delivery tool through an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool, the access tool being adapted to be inserted through a human cervical canal to place an opening of the access tool lumen within a uterus when the access tool is inserted through the cervical canal; and a vapor delivery mechanism, the vapor delivery mechanism having a vapor delivery tool and a vapor source, the vapor delivery tool being adapted to be inserted through the access tool to deliver condensable vapor from the vapor source to the uterus, the condensable vapor being adapted to condense within the uterus.

摘要翻译： 为患者子宫提供治疗的方法和系统。 该方法包括以下步骤：通过子宫颈和子宫颈管将入口工具插入子宫; 在将进入工具插入子宫之后，将蒸气输送工具插入入口工具内腔; 将蒸汽通过蒸气递送工具输送到子宫中; 并将蒸气冷凝在子宫内的组织上。 所述系统具有进入工具，所述通道工具适于插入通过人宫颈管，以在所述进入工具插入通过所述子宫颈管时将所述进入工具内腔的开口放置在子宫内; 蒸气输送机构，其具有蒸气输送工具和蒸气源，所述蒸气输送工具适于插入通过进入工具以将可冷凝蒸汽从蒸气源输送到子宫，该可冷凝蒸气适于 在子宫内凝结。

公开(公告)号：US10154871B2

公开(公告)日：2018-12-18

申请号：US13550392

申请日：2012-07-16

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61B18/04 ,  A61B17/34 ,  A61B17/42 ,  A61B18/00

摘要： A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

公开(公告)号：US08221403B2

公开(公告)日：2012-07-17

申请号：US12197111

申请日：2008-08-22

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61B18/04

CPC分类号： A61B18/04 ,  A61B2017/3425 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2018/00005 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/048

摘要： A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

摘要翻译： 为患者子宫提供治疗的方法和系统。 该系统具有内腔的进入工具，当进入工具插入通过子宫颈管道时，进入工具适于插入人宫颈管以将管腔的开口放置在子宫内; 设置在所述进入工具的远侧区域处并适于将所述进入工具密封抵靠内部颈部口的密封件; 密封指示器，其适于向使用者提供所述密封件已经将所述进入工具与所述内部宫颈口密封的指示; 以及适于将可冷凝蒸气通过所述进入工具输送到子宫的蒸汽递送机构，所述可冷凝蒸气适于在子宫内冷凝。

公开(公告)号：US08216217B2

公开(公告)日：2012-07-10

申请号：US12197096

申请日：2008-08-22

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61B18/04

CPC分类号： A61B18/04 ,  A61B2017/3425 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2018/00005 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/048

摘要： In some embodiments the method includes inserting an access tool through a cervix and a cervical canal into the uterus; placing an expansion mechanism in contact with tissue within the uterus to move uterine tissue surfaces away from an opening in an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool adapted to be inserted through a cervical canal to place an opening of an access tool lumen within a uterus; an expansion mechanism adapted to be advanced into the uterus to move uterine tissue surfaces away from the opening in the access tool lumen; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

摘要翻译： 在一些实施例中，该方法包括将进入工具通过子宫颈和子宫颈管插入到子宫中; 使扩张机构与子宫内的组织接触以使子宫组织表面远离入口工具内腔中的开口; 将蒸汽通过蒸气递送工具输送到子宫中; 并将蒸气冷凝在子宫内的组织上。 该系统具有适于通过子宫颈管插入以将入口工具内腔的开口置于子宫内的通路工具; 适于进入子宫以使子宫组织表面远离进入工具内腔中的开口的扩张机构; 以及适于将可冷凝蒸气通过所述进入工具输送到子宫的蒸汽递送机构，所述可冷凝蒸气适于在子宫内冷凝。

公开(公告)号：US20120283717A1

公开(公告)日：2012-11-08

申请号：US13550392

申请日：2012-07-16

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61B18/04

CPC分类号： A61B18/04 ,  A61B2017/3425 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2018/00005 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/048

摘要： A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

摘要翻译： 为患者子宫提供治疗的方法和系统。 该系统具有内腔的进入工具，当进入工具插入通过子宫颈管道时，进入工具适于插入人宫颈管以将管腔的开口放置在子宫内; 设置在所述进入工具的远侧区域处并适于将所述进入工具密封抵靠内部颈部口的密封件; 密封指示器，其适于向使用者提供所述密封件已经将所述进入工具与所述内部宫颈口密封的指示; 以及适于将可冷凝蒸气通过所述进入工具输送到子宫的蒸汽递送机构，所述可冷凝蒸气适于在子宫内冷凝。

公开(公告)号：US08221401B2

公开(公告)日：2012-07-17

申请号：US12197084

申请日：2008-08-22

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61B18/18

CPC分类号： A61B18/04 ,  A61B2017/3425 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2018/00005 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/048

摘要： A method and system of providing therapy to a patient's uterus. The method includes the steps of inserting an access tool through a cervix and a cervical canal into the uterus; actively cooling the cervical canal; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; an active cooling mechanism adapted to cool the cervical canal, the active cooling mechanism having a coolant source; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

摘要翻译： 为患者子宫提供治疗的方法和系统。 该方法包括将进入工具通过子宫颈和子宫颈管插入子宫的步骤; 积极冷却宫颈管; 通过进入工具内腔将蒸气输送到子宫中; 并将蒸气冷凝在子宫内的组织上。 该系统具有内腔的进入工具，当进入工具插入通过子宫颈管道时，进入工具适于插入人宫颈管以将管腔的开口放置在子宫内; 主动冷却机构，其适于冷却颈管，主动冷却机构具有冷却剂源; 以及适于将可冷凝蒸气通过所述进入工具输送到子宫的蒸汽递送机构，所述可冷凝蒸气适于在子宫内冷凝。

公开(公告)号：US20090054868A1

公开(公告)日：2009-02-26

申请号：US12197084

申请日：2008-08-22

申请人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

发明人： Hugh R. Sharkey ,  Ramiro Reyes ,  Kurt D. Sparks

IPC分类号： A61M31/00

CPC分类号： A61B18/04 ,  A61B2017/3425 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2018/00005 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/048

摘要： A method and system of providing therapy to a patient's uterus. The method includes the steps of inserting an access tool through a cervix and a cervical canal into the uterus; actively cooling the cervical canal; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; an active cooling mechanism adapted to cool the cervical canal, the active cooling mechanism having a coolant source; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

摘要翻译： 为患者子宫提供治疗的方法和系统。 该方法包括将进入工具通过子宫颈和子宫颈管插入子宫的步骤; 积极冷却宫颈管; 通过进入工具内腔将蒸气输送到子宫中; 并将蒸气冷凝在子宫内的组织上。 该系统具有内腔的进入工具，当进入工具插入通过子宫颈管道时，进入工具适于插入人宫颈管以将管腔的开口放置在子宫内; 主动冷却机构，其适于冷却颈管，主动冷却机构具有冷却剂源; 以及适于将可冷凝蒸气通过所述进入工具输送到子宫的蒸汽递送机构，所述可冷凝蒸气适于在子宫内冷凝。

公开(公告)号：US08500795B2

公开(公告)日：2013-08-06

申请号：US12198010

申请日：2008-08-25

申请人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

发明人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

IPC分类号： A61F2/06

CPC分类号： A61F2/2427 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B17/3468 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/12054 ,  A61B2017/12095 ,  A61F2/2487 ,  A61F2002/2484 ,  A61F2250/0003

摘要： Removable cardiac implants, applicators for inserting, repositioning and/or removing them, and methods of using them are described. In particular, removable or repositionable ventricular partitioning devices are described. Systems including removable implants and applicators for inserting and/or removing them are also described.

摘要翻译： 描述了可移除的心脏植入物，用于插入，重新定位和/或去除它们的施用器以及使用它们的方法。 特别地，描述了可拆卸或可重新定位的心室分配装置。 还描述了包括用于插入和/或移除它们的可移除植入物和施用器的系统。

公开(公告)号：US20090254195A1

公开(公告)日：2009-10-08

申请号：US12422144

申请日：2009-04-10

申请人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

发明人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

IPC分类号： A61F2/04

CPC分类号： A61F2/2487 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12195 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/12095

摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.

摘要翻译： 本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。 本文所述的分隔装置可以包括具有向外偏置构件的增强膜。 增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。 这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。 非生产性部分可以填充材料，包括封闭材料。 密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。 本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

公开(公告)号：US07582051B2

公开(公告)日：2009-09-01

申请号：US11151164

申请日：2005-06-10

申请人： Alexander Khairkhahan ,  Hugh R. Sharkey ,  Serjan D. Nikolic ,  Branislav Radovancevic

发明人： Alexander Khairkhahan ,  Hugh R. Sharkey ,  Serjan D. Nikolic ,  Branislav Radovancevic

IPC分类号： A61F2/00

CPC分类号： A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00243 ,  A61B2017/12095 ,  A61B2017/22061

摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.

摘要翻译： 一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。 分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。 在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。 在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。 加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。 从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。