专利检索 ap:("Hugh Zhu" OR "Alan Cooper" OR "Jagdish Desai" OR "James Wang" OR "Dinanath Rane" OR "Ronald Doll" OR "F. Njoroge" OR "Viyyoor Girijavallabhan") AND inv:"Dinanath Rane" 第 1 页

1.

发明申请
Novel farnesyl protein transferase inhibitors as antitumor agents 失效
标题翻译：新型法呢基蛋白转移酶抑制剂作为抗肿瘤剂

公开(公告)号：US20050059672A1

公开(公告)日：2005-03-17

申请号：US10911340

申请日：2004-08-04

申请人： Hugh Zhu , Alan Cooper , Jagdish Desai , James Wang , Dinanath Rane , Ronald Doll , F. Njoroge , Viyyoor Girijavallabhan

发明人： Hugh Zhu , Alan Cooper , Jagdish Desai , James Wang , Dinanath Rane , Ronald Doll , F. Njoroge , Viyyoor Girijavallabhan

IPC分类号： A61P35/00 , C07D401/06 , A61K31/496 , C07D43/14

CPC分类号： C07D401/06

摘要： Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.

摘要翻译： 公开了下式的新型三环化合物及其药学上可接受的盐或溶剂化物。该化合物可用于抑制法呢基蛋白转移酶。还公开了包含式（I）化合物的药物组合物。还公开了式（I）化合物在制备用于治疗癌症的药物中的用途。

2.

发明申请
Novel farnesyl protein transferase inhibitors and their use to treat cancer 失效
标题翻译：新型法呢基蛋白转移酶抑制剂及其用于治疗癌症的用途

公开(公告)号：US20060154937A1

公开(公告)日：2006-07-13

申请号：US11301308

申请日：2005-12-12

申请人： Dinanath Rane

发明人： Dinanath Rane

IPC分类号： A61K31/496 , C07D491/02

CPC分类号： C07D491/04

摘要： Disclosed are compounds of the formula: wherein R8 represents a cyclic and acyclic moiety to which is bound an imidazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

摘要翻译： 公开了下式的化合物：其中R 8表示与咪唑基烷基结合的环状和非环状部分; R 9表示氨基甲酸酯，脲，酰胺或磺酰胺基; 并且其余的取代基如本文所定义。还公开了使用所公开的化合物治疗癌症的方法和抑制法呢基蛋白转移酶的方法。

3.

发明授权
Process for the preparation of 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy derivatives produced thereby 失效
标题翻译：制备5-氟-5-脱氧和5-表氟-5-脱氧-4,6-二-O-（氨基糖基）-1,3-二氨基二醇的方法和新的5-氟-5-脱氧和由此制备的5-表氟-5-脱氧衍生物

公开(公告)号：US4284764A

公开(公告)日：1981-08-18

申请号：US122097

申请日：1980-02-19

申请人： Peter J. L. Daniels , Dinanath Rane

发明人： Peter J. L. Daniels , Dinanath Rane

IPC分类号： C07H15/234 , A61K31/71 , C07H15/22

CPC分类号： C07H15/234

摘要： A novel process whereby 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols are reacted with a dialkylaminosulfur trifluoride to produce novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents.

摘要翻译： 将4,6-二-O-（氨基糖基）-1,3-二氨基环糊精与二烷基氨基三氟化硫反应以制备新的5-氟-5-脱氧和5-表氟-5-脱氧-4的新方法， 6-二-O-（氨基糖基）-1,3-二氨基环糊精抗菌剂。