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1.发明申请Novel compounds as inhibitors of hepatitis C virus NS3 serine protease 失效新型化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20050288233A1
公开(公告)日：2005-12-29
申请号：US11065509
申请日：2005-02-24
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K38/00 , A61K38/04 , C07D209/52 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/04 , C07K5/06 , C07K5/065 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的疾病的方法。
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![(1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease](/abs-image/US/2005/11/10/US20050249702A1/abs.jpg.150x150.jpg)
2.发明申请(1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease 审中-公开（1R，2S，5S）-N - [（1S）-3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[（1,1-二甲基乙基 ）氨基]羰基]氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基-3-氮杂双环[3.1.0]己烷-2-甲酰胺作为丙型肝炎病毒NS3 / NS4a丝氨酸蛋白酶的抑制剂公开(公告)号：US20050249702A1
公开(公告)日：2005-11-10
申请号：US11121433
申请日：2005-05-04
申请人： F. Njoroge , Srikanth Venkatraman
发明人： F. Njoroge , Srikanth Venkatraman
IPC分类号： A61K31/403 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/21 , C07K5/06
CPC分类号： C07K5/0808 , A61K38/21 , A61K2300/00
摘要： The present invention discloses the compound of Formula 3 as an inhibitor of HCV protease, as well as methods for preparing the compound. In another embodiment, the invention discloses pharmaceutical compositions comprising the compound as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了作为HCV蛋白酶抑制剂的式3化合物，以及制备该化合物的方法。 在另一个实施方案中，本发明公开了包含该化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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3.发明申请公开(公告)号：US20050153900A1
公开(公告)日：2005-07-14
申请号：US11007910
申请日：2004-12-09
IPC分类号： A61K31/401 , A61K38/05 , C07D209/52 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/02 , C07K5/06 , C07K5/107 , C07K7/02 , C07D43/02
CPC分类号： C07D209/52 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/0202 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US20050059672A1
公开(公告)日：2005-03-17
申请号：US10911340
申请日：2004-08-04
申请人： Hugh Zhu , Alan Cooper , Jagdish Desai , James Wang , Dinanath Rane , Ronald Doll , F. Njoroge , Viyyoor Girijavallabhan
发明人： Hugh Zhu , Alan Cooper , Jagdish Desai , James Wang , Dinanath Rane , Ronald Doll , F. Njoroge , Viyyoor Girijavallabhan
IPC分类号： A61P35/00 , C07D401/06 , A61K31/496 , C07D43/14
CPC分类号： C07D401/06
摘要： Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
摘要翻译： 公开了下式的新型三环化合物及其药学上可接受的盐或溶剂化物。 该化合物可用于抑制法呢基蛋白转移酶。 还公开了包含式（I）化合物的药物组合物。 还公开了式（I）化合物在制备用于治疗癌症的药物中的用途。
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公开(公告)号：US20070232549A1
公开(公告)日：2007-10-04
申请号：US11714457
申请日：2007-03-06
申请人： F. Njoroge , Ashok Arasappan , Srikanth Venkatraman , Stephane Bogen , Kevin Chen , Frank Bennett
发明人： F. Njoroge , Ashok Arasappan , Srikanth Venkatraman , Stephane Bogen , Kevin Chen , Frank Bennett
IPC分类号： A61K38/00
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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6.发明申请Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效具有循环P4的新型酮酰胺作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070093430A1
公开(公告)日：2007-04-26
申请号：US11602174
申请日：2006-11-20
申请人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
发明人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K38/04 , C07K5/06 , C07D417/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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7.发明申请Novel compounds as inhibitors of hepatitis C virus NS3 serine protease 失效新型化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070049536A1
公开(公告)日：2007-03-01
申请号：US11542228
申请日：2006-10-03
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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8.发明申请Novel substituted prolines as inhibitors of hepatitis C virus NS3 serine protease 失效新型取代的脯氨酸作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20050272663A1
公开(公告)日：2005-12-08
申请号：US11132083
申请日：2005-05-18
IPC分类号： A61K38/00 , A61K38/04 , A61K38/05 , A61K38/21 , A61K38/55 , C07D401/12 , C07D401/14 , C07D409/14 , C07D417/02 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/083 , C07K5/087 , C07K5/10 , C07K7/02
CPC分类号： C07D401/12 , A61K38/21 , A61K38/212 , C07D401/14 , C07D409/14 , C07K5/0202 , C07K5/0205 , C07K7/02 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的疾病的方法。
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公开(公告)号：US20050267043A1
公开(公告)日：2005-12-01
申请号：US11065572
申请日：2005-02-24
申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
IPC分类号： A61K31/401 , A61K31/403 , A61K31/4035 , A61K31/407 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K38/00 , A61K38/04 , C07D207/10 , C07D209/02 , C07D209/52 , C07D209/70 , C07D295/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D491/04 , C07D495/10 , C07K5/02 , C07K5/04 , C07K5/08 , C07K5/083 , C07K5/087 , C07D43/02
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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10.发明申请Novel ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权具有环状P4'S的新型酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号：US20050222047A1
公开(公告)日：2005-10-06
申请号：US11065647
申请日：2005-02-24
申请人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
发明人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K31/40 , A61K38/00 , A61K38/04 , C07D209/52 , C07D401/12 , C07D417/02 , C07D417/12 , C07D513/04 , C07K5/02 , C07K5/04 , C07K5/08 , C12Q1/70 , C07D43/02 , C07D49/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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