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    Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
    1.
    发明申请
    Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation 审中-公开
    用于生产和筛选用于药物发现和目标验证的大规模组合文库的方法

    公开(公告)号：US20060063169A1

    公开(公告)日：2006-03-23

    申请号：US11061499

    申请日：2005-02-18

    申请人： Huw Nash ,  Seth Birnbaum ,  Edward Wintner ,  Krishna Kalghatgi ,  Gerald Shipps ,  Satish Jindal

    发明人： Huw Nash ,  Seth Birnbaum ,  Edward Wintner ,  Krishna Kalghatgi ,  Gerald Shipps ,  Satish Jindal

    IPC分类号： C40B40/08 ,  C40B40/10

    CPC分类号： G01N33/6845 ,  B01J19/0046 ,  B01J2219/00581 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00695 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B20/04 ,  C40B30/10 ,  C40B40/06 ,  C40B70/00 ,  G01N33/6848 ,  G01N2458/15

    摘要： The present invention provides a method for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups. Methods of use of the mass-coded combinatorial library produced by this method for identifying a ligand to a particular biomolecule are also disclosed.

    摘要翻译： 本发明提供一种生产大量编码的组合文库的方法，该组合文库包含一组具有通式X（Y）N n的化合物，其中X是支架，每个Y独立地是外周 部分，并且n是大于1的整数。该方法包括从外周部分前体组选择外周部分前体子集。 该子集包括足够数量的外周部分前体，其存在衍生自该子集中的外周部分前体的n个外周部分的至少约50个不同组合。 选择外周部分前体的子集，使得衍生自子集的n个外围部分的所有可能组合的至少约90％具有不同于n个外围部分的所有其它组合的分子质量和的分子质量和 。 该方法还包括使外周部分前体子集与具有n个反应性基团的支架前体接触。 还公开了通过该方法产生的用于鉴定特定生物分子的配体产生的批量编码的组合文库的方法。

    Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation
    4.
    发明授权
    Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation 失效
    用于生产和筛选用于药物发现和目标验证的大规模组合文库的方法

    公开(公告)号：US06207861B1

    公开(公告)日：2001-03-27

    申请号：US09024592

    申请日：1998-02-17

    申请人： Huw M. Nash ,  Seth Birnbaum ,  Edward A. Wintner ,  Krishna Kalghatgi ,  Gerald Shipps ,  Satish Jindal

    发明人： Huw M. Nash ,  Seth Birnbaum ,  Edward A. Wintner ,  Krishna Kalghatgi ,  Gerald Shipps ,  Satish Jindal

    IPC分类号： C07C23100

    CPC分类号： B01J19/0046 ,  B01J2219/00581 ,  B01J2219/00722 ,  C40B40/06 ,  C40B70/00 ,  Y10T436/24

    摘要： The present invention provides a method for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups. Methods of use of the mass-coded combinatorial library produced by this method for identifying a ligand to a particular biomolecule are also disclosed.

    摘要翻译： 本发明提供一种生产大量编码的组合文库的方法，其包含一组具有通式X（Y）n的化合物，其中X是支架，每个Y独立地是外围部分，n是整数 该方法包括从外周部分前体组选择外周部分前体子集。 该子集包括足够数量的外周部分前体，其存在衍生自该子集中的外周部分前体的n个外周部分的至少约50个不同组合。 选择外周部分前体的子集，使得衍生自子集的n个外围部分的所有可能组合的至少约90％具有不同于n个外围部分的所有其它组合的分子质量和的分子量和 。 该方法还包括使外周部分前体子集与具有n个反应性基团的支架前体接触。 还公开了通过该方法产生的用于鉴定特定生物分子的配体产生的批量编码的组合文库的方法。

    Application instrumentation and monitoring
    5.
    发明申请
    Application instrumentation and monitoring 有权

    公开(公告)号：US20060123101A1

    公开(公告)日：2006-06-08

    申请号：US10995020

    申请日：2004-11-22

    申请人： Donato Buccella ,  Seth Birnbaum ,  Nicholas Stamos ,  Leonard Halio ,  Dwayne Carson ,  Luis Fernandes

    发明人： Donato Buccella ,  Seth Birnbaum ,  Nicholas Stamos ,  Leonard Halio ,  Dwayne Carson ,  Luis Fernandes

    IPC分类号： G06F15/173

    CPC分类号： G06F21/554 ,  G06F21/552 ,  G06F21/6245 ,  G06F2221/2101 ,  Y10S707/99939

    摘要： A data processing application logging, recording, and reporting process and infrastructure. Compliance with regulatory directives such as HIPAA, internal organizational and corporate, personal information privacy, and other security policies can thus be enforced without the need to recode legacy application software. In one preferred embodiment, a core agent process provides “listener” functionality that captures user input events, such as keyboard and mouse interactions, between a user and a legacy application of interest. The agent obtains instructions for how to deal with such events, accessing information that describes the application's behavior as already captured by an application profiler tool. Keyboard and mouse data entry sequences, screen controls and fields of interest are tagged during application profiling process. This data is stored in application profile developed for each mode of a legacy application. The technique can be implemented in various Information Technology (IT) environments including mainframe/terminal applications and/or client/server applications. Thus, full coverage of “fat” client, “thin” client, and legacy “mainframe” applications can be provided with a common approach across an enterprise.

    Managed distribution of digital assets
    6.
    发明申请
    Managed distribution of digital assets 有权
    数字资产的管理分配

    公开(公告)号：US20050060537A1

    公开(公告)日：2005-03-17

    申请号：US10706871

    申请日：2003-11-12

    申请人： Nicholas Stamos ,  Seth Birnbaum ,  Tomas Revesz ,  Donato Buccella ,  Keith MacDonald ,  Dwayne Carson ,  William Fletcher

    发明人： Nicholas Stamos ,  Seth Birnbaum ,  Tomas Revesz ,  Donato Buccella ,  Keith MacDonald ,  Dwayne Carson ,  William Fletcher

    IPC分类号： G06F20060101 ,  G06F11/30 ,  H04L9/00

    CPC分类号： H04L63/10 ,  G06F21/552 ,  H04L41/0613 ,  H04L41/147 ,  H04L43/0811

    摘要： A technique for establishing usage control over digital assets such as computer files. The system model not only tracks authorized users' access to files, but monitors passage of such files to uncontrollable removable storage media or through network connections and the like which may indicate possible abuse of access rights. In accordance with a preferred embodiment, an autonomous independent agent process running at a point of use, such a background process in a client operating system kernel, interrupts requests for access to resources. The agent process senses low level system events, filters, and aggregates them. A policy engine analyzes sequences of aggregate events to determine when policy violations occur.

    摘要翻译： 一种用于建立诸如计算机文件等数字资产的使用控制的技术。 系统模型不仅跟踪授权用户对文件的访问，而且监视这些文件通过不可控制的可移动存储介质，或通过可能指示可能滥用访问权限的网络连接等。 根据优选实施例，在使用点运行的自主独立代理进程，客户端操作系统内核中的这种后台进程中断对资源的访问请求。 代理进程感知低级系统事件，过滤器和聚合它们。 策略引擎分析聚合事件的顺序，以确定何时发生策略违规。

    Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
    7.
    发明授权
    Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation 有权
    用于生产和筛选用于药物发现和目标验证的大规模组合文库的方法

    公开(公告)号：US06721665B2

    公开(公告)日：2004-04-13

    申请号：US10133109

    申请日：2002-04-26

    申请人： Seth Birnbaum ,  Edward A. Wintner

    发明人： Seth Birnbaum ,  Edward A. Wintner

    IPC分类号： C06F1700

    CPC分类号： G01N33/6845 ,  B01J19/0046 ,  B01J2219/00581 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00695 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B20/04 ,  C40B30/10 ,  C40B40/06 ,  C40B70/00 ,  G01N33/6848 ,  G01N2458/15

    摘要： The present invention provides an apparatus for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The apparatus comprises a digital processor assembly for selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. Methods of use of the mass-coded combinatorial library produced by this apparatus are also disclosed.

    摘要翻译： 本发明提供一种用于生产大量编码的组合文库的装置，其包括一组具有通式X（Y）n的化合物，其中X是支架，每个Y独立地是外围部分，n是整数 大于1.该装置包括用于从外围部分前体集合中选择外围部分前体子集的数字处理器组件。 该子集包括足够数量的外周部分前体，其存在衍生自该子集中的外周部分前体的n个外周部分的至少约50个不同组合。 选择外周部分前体的子集，使得衍生自子集的n个外围部分的所有可能组合的至少约90％具有不同于n个外围部分的所有其它组合的分子质量和的分子质量和 。 还公开了使用由该装置产生的大规模组合文库的方法。