公开(公告)号：US20120184499A1

公开(公告)日：2012-07-19

申请号：US13427352

申请日：2012-03-22

申请人： Hyeong Kyu LEE ,  Sei Ryang-Oh ,  Kyung Seop AHN ,  Sang Ku LEE ,  Joong Ku LEE ,  Ok Kyoung KWON ,  Doo Young KIM ,  Hyouk JOUNG ,  Gui Hua QUAN ,  Mi Jin KIM ,  Bo Young PARK

发明人： Hyeong Kyu LEE ,  Sei Ryang-Oh ,  Kyung Seop AHN ,  Sang Ku LEE ,  Joong Ku LEE ,  Ok Kyoung KWON ,  Doo Young KIM ,  Hyouk JOUNG ,  Gui Hua QUAN ,  Mi Jin KIM ,  Bo Young PARK

IPC分类号： A61K31/7048 ,  A61P11/06 ,  A61P29/00 ,  A61P37/08

CPC分类号： A61K31/7048 ,  A61K9/2059 ,  A61K9/4866

摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

公开(公告)号：US20120183632A1

公开(公告)日：2012-07-19

申请号：US13427334

申请日：2012-03-22

申请人： Hyeong Kyu LEE ,  Sei Ryang OH ,  Kyung Seop AHN ,  Sang Ku LEE ,  Joong Ku LEE ,  Ok Kyoung KWON ,  Doo Young KIM ,  Hyouk JOUNG ,  Gui Hua QUAN ,  Mi Jin KIM ,  Bo Young PARK

发明人： Hyeong Kyu LEE ,  Sei Ryang OH ,  Kyung Seop AHN ,  Sang Ku LEE ,  Joong Ku LEE ,  Ok Kyoung KWON ,  Doo Young KIM ,  Hyouk JOUNG ,  Gui Hua QUAN ,  Mi Jin KIM ,  Bo Young PARK

IPC分类号： A61K36/68 ,  A61P29/00 ,  A61P37/08 ,  A61K31/7048

CPC分类号： A61K36/185 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/352 ,  A61K36/68 ,  A61K36/80 ,  C07H17/04 ,  A23V2250/21 ,  A23V2200/324 ,  A23V2200/304

摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

摘要翻译： 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。