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1.发明申请公开(公告)号：US20120183632A1
公开(公告)日：2012-07-19
申请号：US13427334
申请日：2012-03-22
Applicant: Hyeong Kyu LEE , Sei Ryang OH , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
Inventor： Hyeong Kyu LEE , Sei Ryang OH , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
IPC: A61K36/68 , A61P29/00 , A61P37/08 , A61K31/7048
CPC classification number: A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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2.发明申请Composition comprising an extract of tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权组合物，其包含从其中分离的天竺葵提取物和由其分离的天竺葵酸，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US20090148542A1
公开(公告)日：2009-06-11
申请号：US11989053
申请日：2006-07-18
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
CPC classification number: C07J53/00 , A23L33/105 , A61K36/185 , Y10S514/826
Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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3.发明申请COMPOSITION COMPRISING (S)-(-)-BENPROPERINE FOR PREVENTING OR TREATING CANCER 审中-公开包含（S） - （ - ） - 用于预防或治疗癌症的化合物的组合物公开(公告)号：US20160095845A1
公开(公告)日：2016-04-07
申请号：US14876509
申请日：2015-10-06
Applicant: Byoung Mog KWON , Dong Cho HAN , Sang Ku LEE , Yu Jin LEE , Yoon Jung JEON , Jiyeon CHOI , Ah-Rum HA , Young Min HAN
Inventor： Byoung Mog KWON , Dong Cho HAN , Sang Ku LEE , Yu Jin LEE , Yoon Jung JEON , Jiyeon CHOI , Ah-Rum HA , Young Min HAN
IPC: A61K31/4453 , A61K45/06
CPC classification number: A61K31/4453 , A61K45/06
Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising (S)-(−)-benproperine or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for preventing or treating cancer using the same.
Abstract translation: 本发明涉及用于预防或治疗癌症的药物组合物，其包含（S） - （ - ） - 苯丙氨酸或其药学上可接受的盐作为活性成分，以及使用其的预防或治疗癌症的方法。
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4.发明授权Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权药物组合物，其包含假单胞菌属植物提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US08974837B2
公开(公告)日：2015-03-10
申请号：US13427334
申请日：2012-03-22
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
IPC: A61K36/00 , A61K36/185 , A23L1/30 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04
CPC classification number: A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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公开(公告)号：US20120184499A1
公开(公告)日：2012-07-19
申请号：US13427352
申请日：2012-03-22
Applicant: Hyeong Kyu LEE , Sei Ryang-Oh , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
Inventor： Hyeong Kyu LEE , Sei Ryang-Oh , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
IPC: A61K31/7048 , A61P11/06 , A61P29/00 , A61P37/08
CPC classification number: A61K31/7048 , A61K9/2059 , A61K9/4866
Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
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Patent Agency Ranking
6.发明授权Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers 有权用于预防和治疗癌症的二芳基 - 异恶唑衍生物的药物组合物公开(公告)号：US07250432B2
公开(公告)日：2007-07-31
申请号：US10969291
申请日：2004-10-20
Applicant: Byoung-Mog Kwon , Kwang-Hee Son , Dong-Cho Han , Sang-Ku Lee , Ki-Deok Shin , Sun-Bok Jeon , Jung-Hoon Oh
Inventor： Byoung-Mog Kwon , Kwang-Hee Son , Dong-Cho Han , Sang-Ku Lee , Ki-Deok Shin , Sun-Bok Jeon , Jung-Hoon Oh
IPC: A61K31/42 , C07D261/06
CPC classification number: C07D261/08
Abstract: The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.
Abstract translation: 本发明涉及用于预防和治疗含有二芳基 - 异恶唑衍生物作为有效成分的癌症的药物组合物。 本发明的二芳基 - 异恶唑衍生物抑制乳腺癌细胞系的转移和血管发生，从而可以作为转移抑制剂和进一步作为预防和治疗血管生成相关疾病的药物组合物，包括癌症，类风湿性关节炎， 牛皮癣或眼球引起的血管发生疾病等
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7.发明授权Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权药物组合物，其包含假单胞菌长柄菌的提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US08455541B2
公开(公告)日：2013-06-04
申请号：US13427352
申请日：2012-03-22
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
IPC: A61K31/35
CPC classification number: A61K31/7048 , A61K9/2059 , A61K9/4866
Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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8.发明授权Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权药物组合物，其包含假单胞菌属植物提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US08168235B2
公开(公告)日：2012-05-01
申请号：US11916216
申请日：2006-05-30
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
IPC: A61K36/00
CPC classification number: A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其分离的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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9.发明授权Composition comprising an extract of Tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权组合物，其包含从其中分离的天竺葵提取物和由其分离的含有抗炎，抗过敏和抗哮喘活性的叶酸公开(公告)号：US07763286B2
公开(公告)日：2010-07-27
申请号：US11989053
申请日：2006-07-18
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
CPC classification number: C07J53/00 , A23L33/105 , A61K36/185 , Y10S514/826
Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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公开(公告)号：US20080260934A1
公开(公告)日：2008-10-23
申请号：US11885031
申请日：2006-01-12
Applicant: Song Hae Bok , Sang-Ku Lee , Tae-sook Jeong , Eun-eai Kim , Myung-sook Choi
Inventor： Song Hae Bok , Sang-Ku Lee , Tae-sook Jeong , Eun-eai Kim , Myung-sook Choi
IPC: A23L1/30
CPC classification number: A23C9/13 , A23C9/152 , A23L13/426 , A23L27/10 , A23L33/105 , A23V2002/00 , A23V2250/2116 , A23V2250/2132 , A23V2250/21 , A23V2200/332 , A23V2250/28 , A23V2250/0644
Abstract: The present invention is related to food for preventing fatness and hyperlipidemia, which shows prominent effects capable of providing food excellent for preventing fatness and hyperlipidemiaby preparing powders or mixed powders, boiling water extracts or ethanol extracts of plants containing plenty of bioflavonoid substances, polyphenolic substances or diet fibers, and then treating meats products, processed meats products or dairy products with those preparation.
Abstract translation: 本发明涉及用于预防脂肪和高脂血症的食物，其显示出能够提供优异的预防脂肪食物的食品和制备粉剂或混合粉末的高脂蛋白，沸水提取物或含有大量生物类黄酮物质的植物的乙醇提取物，多酚类物质或 饮食纤维，然后用这些准备处理肉制品，加工肉制品或乳制品。
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