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公开(公告)号：US11414485B2
公开(公告)日：2022-08-16
申请号：US16687387
申请日：2019-11-18
Applicant: I-MAB Biopharma US Limited
Inventor： Lei Fang , Zhengyi Wang , Bingshi Guo , Jingwu Zang , Wenqing Jiang , Yongqiang Wang
Abstract: The present disclosure provides antibodies that bind Lymphocyte Activation Gene-3 (LAG-3). Also provided are methods of stimulating an immune response, inhibiting growth of tumor cells, and treating an autoimmune, inflammatory, or viral disease.
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公开(公告)号：US20200347146A1
公开(公告)日：2020-11-05
申请号：US16963091
申请日：2019-07-25
Applicant: I-Mab Biopharma US Limited
Inventor： Zhengyi Wang , Lei Fang , Bingshi Guo , Jingwu Zang , Qiumei Yang
IPC: C07K16/28
Abstract: Provided are bispecific antibodies capable of binding to human CD73 protein and human PD-L1 protein. These bispecific C antibodies are effective in treating cancer.
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公开(公告)号：US10973853B2
公开(公告)日：2021-04-13
申请号：US16483870
申请日：2019-02-11
Applicant: I-Mab Biopharma US Limited
Inventor： Feifei Cui , Lei Fang , Bingshi Guo , Zhengyi Wang , Jingwu Zang
Abstract: The present disclosure provides antibodies and fragments thereof having specificity to a human T cell immunoreceptor with Ig and ITIM domains (TIGIT) protein. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and viral infections are also provided.
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公开(公告)号：US20210054093A1
公开(公告)日：2021-02-25
申请号：US16989702
申请日：2020-08-10
Applicant: I-Mab Biopharma US Limited
Inventor： Zhengyi Wang , Lei Fang , Bingshi Guo , Jingwu Zang
Abstract: The present invention provides novel CD47 antibodies or immunologically active fragments thereof that have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination, as well as pharmaceutical compositions containing such antibodies that can be used for treatment diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation.
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公开(公告)号：US20210015858A1
公开(公告)日：2021-01-21
申请号：US16483870
申请日：2019-02-11
Applicant: I-MAB BIOPHARMA US LIMITED
Inventor： Feifei Cui , Lei Fang , Bingshi Guo , Zhengyi Wang , Jingwu Zang
Abstract: The present disclosure provides antibodies and fragments thereof having specificity to a human T cell immunoreceptor with Ig and ITIM domains (TIGIT) protein. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and viral infections are also provided.
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Patent Agency Ranking
公开(公告)号：US20200317789A1
公开(公告)日：2020-10-08
申请号：US16909400
申请日：2020-06-23
Applicant: I-MAB Biopharma US Limited
Inventor： Lei Fang , Zhengyi Wang , Bingshi Guo , Jingwu Zang
IPC: C07K16/28 , A61P31/20 , A61P31/14 , A61P35/00 , A61P35/02 , A61P31/18 , A61P31/22 , A61P31/08 , A61P31/04 , A61P31/06 , A61P31/16 , A61K35/17
Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.
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公开(公告)号：US11613577B2
公开(公告)日：2023-03-28
申请号：US16785953
申请日：2020-02-10
Applicant: I-MAB Biopharma US Limited
Inventor： Zhengyi Wang , Lei Fang , Bingshi Guo , Jingwu Zang
IPC: C07K16/00 , C07K16/28 , A61P35/00 , A61K9/00 , A61K9/06 , A61K35/17 , A61K39/395 , C07K16/40 , G01N33/574 , A61K39/00
Abstract: Provided are anti-CD73 antibodies or fragments thereof. The antibodies or fragments therefore include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. More generally, antibodies or fragments thereof are described which have specificity to one or more amino acid residues selected from the C-terminal half of a human CD73 protein, such as those in the C-terminal domains. Specific epitope amino acids in these domains include Y345, D399, E400, R401 and R480. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer are also provided.
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公开(公告)号：US20200377611A1
公开(公告)日：2020-12-03
申请号：US16989670
申请日：2020-08-10
Applicant: I-Mab Biopharma US Limited
Inventor： Zhengyi Wang , Lei Fang , Bingshi Guo , Jingwu Zang
Abstract: The present invention provides novel CD47 antibodies or immunologically active fragments thereof that have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination, as well as pharmaceutical compositions containing such antibodies that can be used for treatment diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation.
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公开(公告)号：US20200071403A1
公开(公告)日：2020-03-05
申请号：US16687387
申请日：2019-11-18
Applicant: I-MAB Biopharma US Limited
Inventor： Lei Fang , Zhengyi Wang , Bingshi Guo , Jingwu Zang , Wenqing Jiang , Yongqiang Wang
Abstract: The present disclosure provides antibodies that bind Lymphocyte Activation Gene-3 (LAG-3). Also provided are methods of stimulating an immune response, inhibiting growth of tumor cells, and treating an autoimmune, inflammatory, or viral disease.
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公开(公告)号：US12091467B2
公开(公告)日：2024-09-17
申请号：US16989702
申请日：2020-08-10
Applicant: I-Mab Biopharma US Limited
Inventor： Zhengyi Wang , Lei Fang , Bingshi Guo , Jingwu Zang
CPC classification number: C07K16/2896 , A61K47/6803 , A61P35/00 , C07K16/30 , G01N33/6893 , A61K39/395 , C07K2317/56 , C07K2317/569 , G01N2333/70596
Abstract: The present invention provides novel CD47 antibodies or immunologically active fragments thereof that have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination, as well as pharmaceutical compositions containing such antibodies that can be used for treatment diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation.
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