公开(公告)号：US20190094220A1

公开(公告)日：2019-03-28

申请号：US15818478

申请日：2017-11-20

Applicant: I-SHOU UNIVERSITY

Inventor： Chih-Feng Kuo ,  Ni-Na Tsao ,  Ching-Chuan Liu ,  Tzong-Shiann Ho

IPC: G01N33/569 ,  C07K16/12

CPC classification number: G01N33/56944 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/1275 ,  G01N2333/315 ,  G01N2469/20

Abstract: A method for treating infection of group A Streptococcus (GAS) includes grouping a patient infected with GAS into an invasive infected candidate. An antibiotic is then administrated to the invasive infected candidate to treat the infection of GAS. Moreover, the patient is grouped into the invasive infected candidate when a first detected level, determined by ex vivo contacting a first biopsy obtained from the patient with a FSBM recombinant protein having an amino acid sequence set forth as SEQ ID NO: 10, is smaller than 0.6.

公开(公告)号：US10345301B2

公开(公告)日：2019-07-09

申请号：US15818478

申请日：2017-11-20

Applicant: I-SHOU UNIVERSITY

Inventor： Chih-Feng Kuo ,  Ni-Na Tsao ,  Ching-Chuan Liu ,  Tzong-Shiann Ho

IPC: A61K39/40 ,  G01N33/569 ,  C07K16/12 ,  A61K39/00

Abstract: A method for treating infection of group A Streptococcus (GAS) includes grouping a patient infected with GAS into an invasive infected candidate. An antibiotic is then administrated to the invasive infected candidate to treat the infection of GAS. Moreover, the patient is grouped into the invasive infected candidate when a first detected level, determined by ex vivo contacting a first biopsy obtained from the patient with a FSBM recombinant protein having an amino acid sequence set forth as SEQ ID NO: 10, is smaller than 0.6.

公开(公告)号：US10391161B2

公开(公告)日：2019-08-27

申请号：US15461120

申请日：2017-03-16

Applicant: I-SHOU UNIVERSITY

Inventor： Chih-Feng Kuo ,  Ni-Na Tsao

IPC: A61K39/09 ,  A61K39/00

Abstract: The invention discloses a FSBM recombinant protein for conferring protection against group C streptococcus infection in an animal subject, comprising: a first peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 5; a second peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 6; a third peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 7; and a fourth peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 8. The invention also discloses a method of protecting an animal subject against group C streptococcus infection.

公开(公告)号：US20180169209A1

公开(公告)日：2018-06-21

申请号：US15461120

申请日：2017-03-16

Applicant: I-SHOU UNIVERSITY

Inventor： Chih-Feng Kuo ,  Ni-Na Tsao

IPC: A61K39/09

CPC classification number: A61K39/092 ,  A61K2039/54 ,  A61K2039/545

Abstract: The invention discloses a FSBM recombinant protein for conferring protection against group C streptococcus infection in an animal subject, comprising: a first peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 5; a second peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 6; a third peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 7; and a forth peptide fragment, having an amino acid sequence set forth as SEQ ID NO. 8. The invention also discloses a method of protecting an animal subject against group C streptococcus infection.