专利检索 ap:("IDENIX PHARMACEUTICALS LLC" OR "Centre National De La Recherche Scientifique" OR "UNIVERSITE DE MONTPELLIER") AND inv:"Jean-Francois Griffon" 第 1 页

1.

发明授权
2′-chloro nucleoside analogs for HCV infection 有权

公开(公告)号：US10513534B2

公开(公告)日：2019-12-24

申请号：US14047862

申请日：2013-10-07

申请人： IDENIX PHARMACEUTICALS LLC , Centre National De La Recherche Scientifique , UNIVERSITE DE MONTPELLIER

发明人： Gilles Gosselin , Christophe Claude Parsy , Francois-Rene Alexandre , Houcine Rahali , Jean-Francois Griffon , Dominique Surleraux , Cyril B. Dousson , Claire Pierra , Adel M. Moussa , Benjamin Alexander Mayes , Alistair James Stewart

IPC分类号： C07H19/06 , C07H19/073 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/173 , C07H19/20 , C07H19/213 , A61K31/7072 , A61K45/06 , A61K38/21 , A61K31/7076 , C07H19/14 , A61K31/7064 , C07H19/12 , A61K31/706 , A61K31/7068 , A61K31/708 , A61K31/403 , A61K31/497 , A61K31/7105 , C07H19/23

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.