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公开(公告)号：US20230013143A1
公开(公告)日：2023-01-19
申请号：US17777193
申请日：2020-11-13
发明人： Hong Chul Yoon , Kyung Mi An , Myong Jae Lee , Jin Hee Lee , Jeong-geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： C07D405/14 , C07D471/04 , C07D413/14 , C07D235/14 , A61P3/10
摘要： Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.
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公开(公告)号：US20230373954A1
公开(公告)日：2023-11-23
申请号：US18228672
申请日：2023-08-01
发明人： Hong Chul Yoon , Joon Tae Park , Jung Woo Lee , Kyung Mi An , A Rang IM , Woo Jin Jeon , Jae Ho Heo , Chang Hee Hong , Jung Eun Park , Te Ik Sohn , Da Hae Hong , Jung Ho Kim , Jae Eui Shin , Yeong Ran Yoo , Min Whan Chang , In Gyu Je , Su Yeon Kang , Yoon Sung Song , Joo Yun Lee
IPC分类号： C07D401/12 , A61P29/00 , A61P1/04
CPC分类号： C07D401/12 , A61P29/00 , A61P1/04
摘要： The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.
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公开(公告)号：US20230192650A1
公开(公告)日：2023-06-22
申请号：US18011084
申请日：2021-06-16
发明人： Hong Chul Yoon , Joon Tae Park , Jung Woo Lee , Kyung Mi An , Rang A IM , Woo Jin Jeon , Jae Ho Heo , Chang Hee Hong , Jung Eun Park , Te Ik Sohn , Da Hae Hong , Jung Ho Kim , Jae Eui Shin , Yeong Ran Yoo , Min Whan Chang , In Gyu Je , Su Yeon Kang , Yoon Sung Song , Joo Yun Lee
IPC分类号： C07D401/12 , A61P29/00 , A61P1/04
CPC分类号： C07D401/12 , A61P29/00 , A61P1/04
摘要： The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.
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公开(公告)号：US11767311B2
公开(公告)日：2023-09-26
申请号：US18011084
申请日：2021-06-16
发明人： Hong Chul Yoon , Joon Tae Park , Jung Woo Lee , Kyung Mi An , Rang A Im , Woo Jin Jeon , Jae Ho Heo , Chang Hee Hong , Jung Eun Park , Te Ik Sohn , Da Hae Hong , Jung Ho Kim , Jae Eui Shin , Yeong Ran Yoo , Min Whan Chang , In Gyu Je , Su Yeon Kang , Yoon Sung Song , Joo Yun Lee
IPC分类号： C07D401/12 , A61P1/04 , A61P29/00
CPC分类号： C07D401/12 , A61P1/04 , A61P29/00
摘要： The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.
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公开(公告)号：US11932618B2
公开(公告)日：2024-03-19
申请号：US18120876
申请日：2023-03-13
发明人： Hong Chul Yoon , Kyung Mi An , Myong Jae Lee , Jin Hee Lee , Jeong-geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-Eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/496 , A61K31/497 , A61P3/10 , C07D211/22 , C07D213/74 , C07D235/14 , C07D239/47 , C07D295/096 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/06 , C07D413/14
CPC分类号： C07D401/04 , A61K31/4545 , A61K31/496 , A61K31/497 , A61P3/10 , C07D211/22 , C07D213/74 , C07D235/14 , C07D239/47 , C07D295/096 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D471/04
摘要： Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.
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公开(公告)号：US20230002348A1
公开(公告)日：2023-01-05
申请号：US17776052
申请日：2020-11-13
发明人： Hong Chul Yoon , Kyung Mi An , Myong Jae Lee , Jin Hee Lee , Jeong-geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-Eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-Gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： C07D401/04 , C07D239/47 , C07D213/74 , C07D401/12 , C07D295/096 , C07D401/14 , C07D405/14 , C07D413/06 , C07D403/06 , C07D211/22
摘要： The present invention provides novel compounds of chemical formula 1, optical isomers of the compounds, or a pharmaceutically acceptable salts of the compounds, or the optical isomers. The compounds, isomers, and salts exhibits excellent activity as GLP-1 receptor agonists. Particularly, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used therapeutic agents for metabolic diseases. In addition, they exhibits excellent pharmacological safety for cardiovascular systems.
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公开(公告)号：US20230212140A1
公开(公告)日：2023-07-06
申请号：US18120876
申请日：2023-03-13
发明人： Hong Chul Yoon , Kyung Mi , myong Jae Lee , Jin Hee Lee , Jeong-Geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-Eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： A61K31/496 , A61K31/4545 , A61K31/497 , A61P3/10
CPC分类号： A61K31/496 , A61K31/4545 , A61K31/497 , A61P3/10
摘要： Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.
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公开(公告)号：US11643403B2
公开(公告)日：2023-05-09
申请号：US17777193
申请日：2020-11-13
发明人： Hong Chul Yoon , Kyung Mi An , Myong Jae Lee , Jin Hee Lee , Jeong-geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-Gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： C07D471/04 , A61P3/10 , C07D405/14 , C07D235/14 , C07D413/14
CPC分类号： C07D405/14 , A61P3/10 , C07D235/14 , C07D413/14 , C07D471/04
摘要： Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.
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