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公开(公告)号：US20200172960A1
公开(公告)日：2020-06-04
申请号：US16782833
申请日：2020-02-05
Applicant: ILLUMINA, INC.
Inventor： Teng Li , Chia-Ling Hsieh , Charles Lin , Han-Yu Chuang
IPC: C12Q1/6806
Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.
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