公开(公告)号：US11624084B2

公开(公告)日：2023-04-11

申请号：US16782833

申请日：2020-02-05

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US20200172960A1

公开(公告)日：2020-06-04

申请号：US16782833

申请日：2020-02-05

Applicant: ILLUMINA, INC.

Inventor： Teng Li ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US20170101676A1

公开(公告)日：2017-04-13

申请号：US15286374

申请日：2016-10-05

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q2535/122 ,  C12Q2537/159 ,  C12Q2537/163 ,  C12Q2563/131

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US10577643B2

公开(公告)日：2020-03-03

申请号：US15286374

申请日：2016-10-05

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US20230193357A1

公开(公告)日：2023-06-22

申请号：US18165153

申请日：2023-02-06

Applicant: ILLUMINA, INC.

Inventor： Li Teng ,  Chia-Ling Hsieh ,  Charles Lin ,  Han-Yu Chuang

IPC: C12Q1/6806

CPC classification number: C12Q1/6806

Abstract: Presented herein are methods and compositions for enhancing specific enrichment of target sequences in a nucleic acid library. Off-target hybridization probes may be used to reduce binding and/or capture of off-target regions of a nucleic acid library in a targeted sequencing workflow. The off-target hybridization probes may be specific for locations known to generate off-target sequencing reads for a particular set of hybridization probes.

公开(公告)号：US20220411859A1

公开(公告)日：2022-12-29

申请号：US16609727

申请日：2018-08-01

Applicant: Illumina, Inc.

Inventor： Yir-Shyuan Wu ,  Xi-Jun Chen ,  Filiz Gorpe-Yasar ,  Falko Noé ,  Charles Lin ,  Tarun Kumar Khurana ,  Foad Mashayekhi ,  Pallavi Daggumati ,  Frank J Steemers ,  Kevin Gunderson ,  Jeffrey S Fisher

IPC: C12Q1/6869 ,  C12N15/10 ,  C12Q1/6806

Abstract: Systems, methods, and compositions provided herein relate to preparation of beads encapsulating genetic material. Some embodiments include preparation of nucleic acid libraries within the bead, wherein the bead includes pores that allow diffusion of reagents while retaining genetic material.