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公开(公告)号:US20210159321A1
公开(公告)日:2021-05-27
申请号:US17099339
申请日:2020-11-16
发明人: Koen Martens , Sybren Santermans , Geert Hellings , David Barge
IPC分类号: H01L29/66 , G01N27/414
摘要: A method for forming a sensor is provided. The method includes: providing an active region comprising a channel having: a length, and a periphery consisting of one or more surfaces having said length, said periphery comprising a first part and a second part, each part having said length, the first part representing from 10 to 75% of the area of the periphery and the second part representing from 25 to 90% of the area of the periphery; providing a first dielectric structure on the entire first part, the first dielectric structure having a maximal equivalent oxide thickness; and providing a second dielectric structure on the entire second part, the second dielectric structure having a minimal equivalent oxide thickness larger than the maximal equivalent oxide thickness of the first dielectric structure.
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公开(公告)号:US20240218441A1
公开(公告)日:2024-07-04
申请号:US18397221
申请日:2023-12-27
申请人: IMEC VZW
IPC分类号: C12Q1/6869 , C12Q1/6825
CPC分类号: C12Q1/6869 , C12Q1/6825
摘要: The present disclosure relates to single-peptide sequencing. A method for sequencing peptides is provided that includes attaching a base end of a peptide to a channel region surface of a biosensor field effect transistor (bio-FET) and obtaining a first measurement of a parameter of the bio-FET, the parameter depending on the bio-FET's threshold voltage. The method further includes providing first molecular probes into the electrolyte gate, each first molecular probe being linked to a respective charge tag, and obtaining a second measurement of the parameter. Then, the method includes determining whether a shift of the parameter occurred between the first and second measurements, which indicates that a first molecular probe attached to an amino acid at a free end of the peptide. If the shift of the parameter occurred, the method includes determining a type of the amino acid based on a type of the first molecular probe.
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公开(公告)号:US11735645B2
公开(公告)日:2023-08-22
申请号:US17099339
申请日:2020-11-16
发明人: Koen Martens , Sybren Santermans , Geert Hellings , David Barge
IPC分类号: H01L29/66 , G01N27/414
CPC分类号: H01L29/6656 , G01N27/4145
摘要: A method for forming a sensor is provided. The method includes: providing an active region comprising a channel having: a length, and a periphery consisting of one or more surfaces having said length, said periphery comprising a first part and a second part, each part having said length, the first part representing from 10 to 75% of the area of the periphery and the second part representing from 25 to 90% of the area of the periphery; providing a first dielectric structure on the entire first part, the first dielectric structure having a maximal equivalent oxide thickness; and providing a second dielectric structure on the entire second part, the second dielectric structure having a minimal equivalent oxide thickness larger than the maximal equivalent oxide thickness of the first dielectric structure.
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