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公开(公告)号：US11850274B2
公开(公告)日：2023-12-26
申请号：US17238943
申请日：2021-04-23
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a WIC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US11648292B2
公开(公告)日：2023-05-16
申请号：US17733260
申请日：2022-04-29
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US10478471B2
公开(公告)日：2019-11-19
申请号：US16502268
申请日：2019-07-03
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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4.发明申请公开(公告)号：US20170304399A1
公开(公告)日：2017-10-26
申请号：US15636486
申请日：2017-06-28
Applicant: IMMATICS BIOTECHNOLOGIES GMBH
Inventor： Jens FRITSCHE , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US11969455B2
公开(公告)日：2024-04-30
申请号：US17358676
申请日：2021-06-25
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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Patent Agency Ranking
公开(公告)号：US09895415B2
公开(公告)日：2018-02-20
申请号：US15636958
申请日：2017-06-29
Applicant: IMMATICS BIOTECHNOLOGIES GMBH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
Abstract: A method of treating a patient who has gastric cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has gastric cancer. A method of treating a patient who has gastric cancer includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the gastric cancer.
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7.发明申请公开(公告)号：US20130323272A1
公开(公告)日：2013-12-05
申请号：US13931413
申请日：2013-06-28
Applicant: Immatics Biotechnologies GmbH
Inventor： Hans Georg Rammensee , Stefan Stevanovic , Cecile Gouttefanges , Toni Weinschenk , Peter Lewandrowski
IPC: A61K39/00
CPC classification number: A61K38/10 , A61K39/0011 , C07H21/00 , C07K7/08 , C07K14/4747 , C07K14/4748 , C07K14/7056 , C07K16/18 , C12N15/10 , C12N15/86
Abstract: The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
Abstract translation: 本发明涉及用于癌症免疫治疗的肽，核酸和细胞。 本发明还涉及存活蛋白衍生的肿瘤相关细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。 本发明具体涉及可衍生自人类肿瘤细胞的HLA I类和II类分子的三种新型肽序列及其变体，其可用于引发抗肿瘤免疫应答的疫苗组合物。
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公开(公告)号：US11273200B2
公开(公告)日：2022-03-15
申请号：US17484703
申请日：2021-09-24
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US11077171B2
公开(公告)日：2021-08-03
申请号：US17161253
申请日：2021-01-28
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US10933118B2
公开(公告)日：2021-03-02
申请号：US16894212
申请日：2020-06-05
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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