公开(公告)号：US20240115609A1

公开(公告)日：2024-04-11

申请号：US18319677

申请日：2023-05-18

Applicant: IMMATICS US, INC.

Inventor： Monique DAO ,  Steffen WALTER ,  Melinda MATA ,  Aleksandra NORWICKA ,  Yannick BULLIARD ,  Sarah MISSELL ,  Sabrina KUTTRUFF-COQUI ,  Norbert HILF

IPC: A61K35/17 ,  A61K31/663 ,  A61K31/675 ,  A61K38/20 ,  C07K14/54 ,  C07K14/55 ,  C12N5/00 ,  C12N5/0783 ,  C12N15/62 ,  C12N15/85

CPC classification number: A61K35/17 ,  A61K31/663 ,  A61K31/675 ,  A61K38/2013 ,  C07K14/5443 ,  C07K14/55 ,  C12N5/0018 ,  C12N5/0636 ,  C12N5/0638 ,  C12N15/62 ,  C12N15/8509 ,  A61K2035/122 ,  C12N2501/155 ,  C12N2501/2302 ,  C12N2501/2315 ,  C12N2501/515 ,  C12N2501/998 ,  C12N2740/10043

Abstract: The present disclosure relates to expansion and activation of T cells. In an aspect, the present disclosure relates to expansion and activation of γδ T cells that may be used for transgene expression. In another aspect, the disclosure relates to expansion and activation of γδ T cells while depleting α- and/or β-TCR positive cells. T cell populations comprising expanded γδ T cell and depleted or reduced α- and/or β-TCR positive cells are also provided for by the instant disclosure. The disclosure further provides for methods of using the disclosed T cell populations.

公开(公告)号：US20250002855A1

公开(公告)日：2025-01-02

申请号：US18886331

申请日：2024-09-16

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Mamta KALRA ,  Ali MOHAMED ,  Steffen WALTER ,  Yannick BULLIARD

IPC: C12N5/0783 ,  A61K39/00 ,  C07K14/725

Abstract: An in vitro method of expanding γδ T cells includes isolating γδ T cells from a blood sample of a human subject, activating the isolated γδ T cells in the presence of an aminobisphosphonate and/or a feeder cell and at least one cytokine, expanding the activated γδ T cells, and optionally restimulating the expanded γδ T cells.

公开(公告)号：US20210285011A1

公开(公告)日：2021-09-16

申请号：US17197927

申请日：2021-03-10

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Mamta KALRA ,  Yannick BULLIARD ,  Steffen WALTER ,  Ali MOHAMED

IPC: C12N15/86 ,  C12N15/10 ,  C07K14/725 ,  C12N15/113

Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.

公开(公告)号：US20240150790A1

公开(公告)日：2024-05-09

申请号：US18501269

申请日：2023-11-03

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Mamta KALRA ,  Yannick BULLIARD ,  Steffen WALTER ,  Ali MOHAMED

IPC: C12N15/86 ,  C07K14/725 ,  C12N15/10 ,  C12N15/113

CPC classification number: C12N15/86 ,  C07K14/7051 ,  C12N15/102 ,  C12N15/113 ,  C12N2830/48

Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.

公开(公告)号：US20220280564A1

公开(公告)日：2022-09-08

申请号：US17281095

申请日：2021-02-23

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Mamta KALRA ,  Ali MOHAMED ,  Steffen WALTER ,  Yannick BULLIARD

IPC: A61K35/17 ,  C07K14/725 ,  C12N5/0783

Abstract: An in vitro method of expanding γδ T cells includes isolating γδ T cells from a blood sample of a human subject, activating the isolated γδ T cells in the presence of an aminobisphosphonate and/or a feeder cell and at least one cytokine, expanding the activated γδ T cells, and optionally restimulating the expanded γδ T cells.

公开(公告)号：US20250075230A1

公开(公告)日：2025-03-06

申请号：US18824203

申请日：2024-09-04

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Mamta KALRA ,  Yannick BULLIARD ,  Steffen WALTER ,  Ali MOHAMED

IPC: C12N15/86 ,  A61K39/00 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/10 ,  C12N15/113

Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.

公开(公告)号：US20250051418A1

公开(公告)日：2025-02-13

申请号：US18590008

申请日：2024-02-28

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Yannick BULLIARD ,  Mamta KALRA

IPC: C07K14/705 ,  A61K39/00 ,  C07K14/725 ,  C12N5/078 ,  C12N5/0783 ,  C12N15/64 ,  C12N15/86

Abstract: A vector containing a first nucleotide sequence S1 encoding a protein Z1, a second nucleotide sequence S2 encoding a protein Z2, a third nucleotide sequence S3 encoding a protein Y1, and a fourth nucleotide sequence S4 encoding a protein Y2, in which Z1 and Z2 form a first dimer and Y1 and Y2 form a second dimer, in which the first dimer Z1Z2 is different from the second dimer Y1Y2.