公开(公告)号：US20220249363A1

公开(公告)日：2022-08-11

申请号：US17730149

申请日：2022-04-26

申请人： IMMUNICOM, INC.

发明人： Thomas ICHIM ,  Amir JAFRI ,  Steven F. JOSEPHS

IPC分类号： A61K9/00 ,  A61K39/00 ,  A61P35/00 ,  G01N33/574

摘要： Disclosed are means, methods and compositions of matter useful for amplification of adaptive immune responses towards neoplastic tissue. In one embodiment, immunization of a patient is performed by a means comprising of administering either an exogenous vaccine or stimulation of immunogenicity of the tumor so as to cause release of antigens/increased exposure of antigens, thus resulting in an “endogenous” vaccine. Subsequent to vaccination a patient is treated by an immunopheresis procedure, in order to allow for removal of “blocking factors” produced by the tumor or produced by cells programmed by tumors to produce said blocking factors. In one embodiment further immunization is performed subsequent to removal of said blocking factors in order to allow for enhancement of adaptive immune responses.

公开(公告)号：US20240252732A1

公开(公告)日：2024-08-01

申请号：US18607187

申请日：2024-03-15

申请人： IMMUNICOM, INC.

发明人： Michael MATHO ,  Steven F. JOSEPHS ,  Annette MARLEAU

IPC分类号： A61M1/36 ,  A61K39/395 ,  A61M1/34 ,  B01D15/38 ,  C07K14/525 ,  C07K14/555 ,  C07K14/705 ,  G01N33/543

CPC分类号： A61M1/362 ,  A61K39/395 ,  A61K39/39516 ,  A61K39/39525 ,  B01D15/3809 ,  B01D15/3828 ,  C07K14/525 ,  C07K14/555 ,  C07K14/70575 ,  G01N33/543 ,  G01N33/54353 ,  A61M1/3496

摘要： A column is disclosed for removal of sTNF-R2 from a body fluid. The column has a compartment, an inlet coupled to the compartment and configured to receive the body fluid, and a substrate disposed within the compartment. A capture ligand is coupled to the substrate and has a modified sequence with an amino acid substitution in a reference sequence that includes a portion of a natural TNF sequence. The modified sequence has an affinity for the sTNF-R2 that is greater than an affinity of the reference sequence for the sTNF-R2.

公开(公告)号：US20220409795A1

公开(公告)日：2022-12-29

申请号：US17843950

申请日：2022-06-17

申请人： IMMUNICOM, INC.

发明人： Michael MATHO ,  Steven F. JOSEPHS ,  Annette MARLEAU

IPC分类号： A61M1/36 ,  B01D15/38

摘要： A column is disclosed for removal of sTNF-R2 from a body fluid. The column has a compartment, an inlet coupled to the compartment and configured to receive the body fluid, and a substrate disposed within the compartment. A capture ligand is coupled to the substrate and has a modified sequence with an amino acid substitution in a reference sequence that includes a portion of a natural TNF sequence. The modified sequence has an affinity for the sTNF-R2 that is greater than an affinity of the reference sequence for the sTNF-R2.