公开(公告)号：US20220370525A1

公开(公告)日：2022-11-24

申请号：US17811542

申请日：2022-07-08

Applicant: IMMUNOBIOME INC.

Inventor： Sin-Hyeog IM ,  Garima SHARMA ,  Sun-Hee PARK ,  Amit SHARMA

IPC: A61K35/747 ,  C12N1/20 ,  A23L33/135 ,  A61P35/00

Abstract: The present invention relates to a novel Lactobacillus plantarum IMB19 strain, polysaccharides derived from the strain, and a use thereof. A novel Lactobacillus plantarum IMB19 strain and polysaccharides derived from the strain of the present invention exhibit an excellent CD8+T cell activity stimulating ability and Treg cell inhibitory activity, and stimulate and improve an antitumor immune response through various mechanisms such as increased macrophage infiltration in CPS tumors and differentiation and reprogramming of macrophages into an inflammatory phenotype (M1). Therefore, a strain and polysaccharides derived from the strain of the present invention can be effectively used for immune regulation, especially immune boosting, in a subject, and can inhibit tumor growth by inducing and enhancing an antitumor immune response. A novel strain and polysaccharides derived from the strain of the present invention are useful in the prevention, alleviation or treatment of such as tumors, infectious diseases and various immune diseases that are the cause of or symptom of immune dysfunction.