公开(公告)号：US20250025521A1

公开(公告)日：2025-01-23

申请号：US18577252

申请日：2022-07-07

Applicant: IMMUNOBIOME INC. ,  POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Sin-Hyeog IM ,  Garima SHARMA ,  Amit Kumar SHARMA ,  Sunhee PARK

IPC: A61K35/747 ,  A61K31/715 ,  A61K35/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to a combination use of a novel Lactobacillus plantarum IMB19 strain and/or polysaccharides derived from the strain with an anticancer drug for preventing or treating tumors. The novel Lactobacillus plantarum IMB19 strain and polysaccharides derived from the strain of the present invention exhibit an excellent ability to stimulate CD8+T cell activity and exhibit excellent Treg cell inhibitory activity, and stimulate and improve antitumor immune response through various mechanisms such as increased macrophage infiltration in CPS tumors and differentiation and reprogramming of macrophages into an inflammatory phenotype (M1). Furthermore, the strain and the polysaccharides may significantly increase antitumor immune response when administered in combination with an anticancer drug, particularly an immuno-anticancer drug such as a PD-1 or PD-L1 inhibitor (e.g., a PD-1 antibody, a PD-L1 antibody, or the like), and exhibit a remarkable tumor growth suppression effect compared to the case of using the anticancer drug alone. Therefore, the present invention can be effectively used to prevent, relieve, or treat tumors through administration in combination with various anticancer drugs.

公开(公告)号：US20220370525A1

公开(公告)日：2022-11-24

申请号：US17811542

申请日：2022-07-08

Applicant: IMMUNOBIOME INC.

Inventor： Sin-Hyeog IM ,  Garima SHARMA ,  Sun-Hee PARK ,  Amit SHARMA

IPC: A61K35/747 ,  C12N1/20 ,  A23L33/135 ,  A61P35/00

Abstract: The present invention relates to a novel Lactobacillus plantarum IMB19 strain, polysaccharides derived from the strain, and a use thereof. A novel Lactobacillus plantarum IMB19 strain and polysaccharides derived from the strain of the present invention exhibit an excellent CD8+T cell activity stimulating ability and Treg cell inhibitory activity, and stimulate and improve an antitumor immune response through various mechanisms such as increased macrophage infiltration in CPS tumors and differentiation and reprogramming of macrophages into an inflammatory phenotype (M1). Therefore, a strain and polysaccharides derived from the strain of the present invention can be effectively used for immune regulation, especially immune boosting, in a subject, and can inhibit tumor growth by inducing and enhancing an antitumor immune response. A novel strain and polysaccharides derived from the strain of the present invention are useful in the prevention, alleviation or treatment of such as tumors, infectious diseases and various immune diseases that are the cause of or symptom of immune dysfunction.