公开(公告)号：US11305131B2

公开(公告)日：2022-04-19

申请号：US16554831

申请日：2019-08-29

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Mark DeWhirst ,  Neil L. Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada

IPC分类号： A61N5/06 ,  A61K41/00 ,  A61N5/10 ,  A61K31/352

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.

公开(公告)号：US11992697B2

公开(公告)日：2024-05-28

申请号：US17655683

申请日：2022-03-21

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Mark Dewhirst ,  Neil L. Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada

IPC分类号： A61N5/06 ,  A61K31/352 ,  A61K41/00 ,  A61N5/10

CPC分类号： A61N5/062 ,  A61K31/352 ,  A61K41/0066 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N5/10 ,  A61N2005/1089 ,  A61N2005/1098

摘要： A method for treating a diseased site in a human or animal body is provided which includes injecting in a diseased site one or more phosphors which are capable of emitting ultraviolet or visible light into the body;



infusing the diseased site with a photoactivatable drug;
applying an initiation energy from an initiation energy source comprising an x-ray, gamma ray, or electron source to thereby initiate emission of ultraviolet or visible light into the body; and
controlling a dose of the initiation energy with a processor to produce (i) a cytotoxicity inside the diseased site of greater than 20% or (ii) a day-25 stable tumor volume,
wherein the processor is programmed to apply the initiation energy in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode, or (ii) a pulsed fluoroscopy mode.

公开(公告)号：US10441810B2

公开(公告)日：2019-10-15

申请号：US15434871

申请日：2017-02-16

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Mark Dewhirst ,  Neil L. Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada

IPC分类号： A61N5/06 ,  A61K41/00 ,  A61N5/10 ,  A61K31/352

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.

公开(公告)号：US20220226666A1

公开(公告)日：2022-07-21

申请号：US17655683

申请日：2022-03-21

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Frederic A. Bourke, JR. ,  Harold Walder ,  Mark Dewhirst ,  Neil L. Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada

IPC分类号： A61N5/06 ,  A61K31/352 ,  A61K41/00

摘要： A method for treating a diseased site in a human or animal body is provided which includes injecting in a diseased site one or more phosphors which are capable of emitting ultraviolet or visible light into the body;
infusing the diseased site with a photoactivatable drug;
applying an initiation energy from an initiation energy source comprising an x-ray, gamma ray, or electron source to thereby initiate emission of ultraviolet or visible light into the body; and
controlling a dose of the initiation energy with a processor to produce (i) a cytotoxicity inside the diseased site of greater than 20% or (ii) a day-25 stable tumor volume,
wherein the processor is programmed to apply the initiation energy in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode, or (ii) a pulsed fluoroscopy mode.

公开(公告)号：US11207409B2

公开(公告)日：2021-12-28

申请号：US15992852

申请日：2018-05-30

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Frederic A. Bourke, Jr. ,  Mark Dewhirst ,  Neil Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada ,  Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Harold Walder

IPC分类号： A61K41/00 ,  A61K31/37 ,  A61K45/06 ,  A61K9/00 ,  A61N5/06 ,  A61N5/10 ,  A61K31/409 ,  A61P35/00

摘要： A system (and associated method) for treating a human or animal body. The system has a photoactivatable drug for treating a first diseased site, a first pharmaceutically acceptable carrier including one or more phosphorescent or fluorescent agents which are capable of emitting an activation energy into the body which activates the photoactivatable drug, a first device which infuses the first diseased site with a photoactivatable drug and the first pharmaceutically acceptable carrier, a first energy source which irradiates the diseased site with an initiation energy to thereby initiate emission of the activation energy into the body, and a supplemental treatment device which administers one or both of a therapeutic drug or radiation to the body at a second diseased site or the first diseased site, to provide an immune system stimulation in the body.