公开(公告)号：US20150202294A1

公开(公告)日：2015-07-23

申请号：US14603539

申请日：2015-01-23

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Wenle XIA ,  David GOODEN ,  Erik J. SODERBLOM ,  Eric J. TOONE ,  Neil L. SPECTOR ,  Wayne F. BEYER, JR. ,  Harold WALDER

IPC分类号： A61K41/00 ,  A61K51/12 ,  A61K31/37 ,  A61K31/4709 ,  A61K31/436 ,  A61K31/517

CPC分类号： A61K31/436 ,  A61K31/37 ,  A61K31/4709 ,  A61K31/517 ,  A61K41/0066 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

摘要翻译： 用于治疗受试者细胞增殖疾病或病症的方法，包括将缺乏DNA交联基序的补骨脂素衍生物施用于癌细胞，施用补骨脂素或其衍生物和拉帕替尼，或施用补骨脂素或其衍生物和神经胶质细胞 ，并且进一步施加起始辐射能量形成能量源。

公开(公告)号：US20200009398A1

公开(公告)日：2020-01-09

申请号：US16554831

申请日：2019-08-29

申请人： IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

发明人： Mark OLDHAM ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Mark DEWHIRST ,  Neil L. SPECTOR ,  Paul YOON ,  Justus ADAMSON ,  David ALCORTA ,  Kim LYERLY ,  Leihua LIU ,  Takuya OSADA

IPC分类号： A61N5/06 ,  A61K31/352 ,  A61K41/00

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.

公开(公告)号：US20170157418A1

公开(公告)日：2017-06-08

申请号：US15434871

申请日：2017-02-16

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark OLDHAM ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Harold WALDER ,  Frederic A. BOURKE, JR. ,  Mark DEWHIRST ,  Neil L. SPECTOR ,  Paul YOON ,  Justus ADAMSON ,  David ALCORTA ,  Kim LYERLY ,  Leihua LIU ,  Takuya OSADA

IPC分类号： A61N5/06 ,  A61K31/352 ,  A61K41/00 ,  A61N5/10

CPC分类号： A61N5/062 ,  A61K31/352 ,  A61K31/525 ,  A61K33/00 ,  A61K35/00 ,  A61K38/00 ,  A61K41/0066 ,  A61N5/10 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1089 ,  A61N2005/1098

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.