公开(公告)号：US20240262869A1

公开(公告)日：2024-08-08

申请号：US18004065

申请日：2021-06-29

Applicant: Indian Institute of Science ,  MYNVAX PRIVATE LIMITED

Inventor： Raghavan VARADARAJAN ,  Sameer Kumar MALLADI ,  Shahbaz AHMED ,  Suman PANDEY ,  Randhir SINGH

IPC: C07K14/005 ,  A61K9/00 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K14/005 ,  A61K9/0019 ,  A61K39/215 ,  A61P31/14 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071

Abstract: The present disclosure discloses the polypeptide fragment having an amino acid sequence with at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, and SEQ ID NO: 6. The present disclosure also discloses nucleic acid fragment encoding the polypeptide fragment as described herein. Moreover, the present disclosure also discloses recombinant construct, recombinant vector and recombinant host cells. Also disclosed herein is an immunogenic composition comprising the polypeptide fragment as described herein, and a method for preparing the said immunogenic composition. The immunogenic composition is in form of vaccine. The polypeptide fragment and/or immunogenic composition is capable of eliciting protection against severe acute respiratory syndrome coronavirus 2. A kit comprising the polypeptide, or the immunogenic composition as described herein is also disclosed.

公开(公告)号：US20170204142A1

公开(公告)日：2017-07-20

申请号：US15305575

申请日：2015-04-29

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan VARADARAJAN ,  Vamsee V. Aditya MALLAJOSYUL

IPC: C07K14/005 ,  A61K39/145

CPC classification number: C07K14/005 ,  A61K39/145 ,  C07K2319/40 ,  C12N2760/16034 ,  C12N2760/16134

Abstract: The present disclosure relates to a polypeptide comprising hemagglutinin stem domain fragments that can elicit broadly cross-reactive anti-influenza antibodies and confer protection against influenza virus. The disclosure also provides a method of preparing the polypeptide with biochemical and biophysical properties that enhance its immunogenic properties. Also provided are recombinant DNA constructs, vectors, and host cells comprising the nucleic acid encoding the polypeptide, as well as uses of the polypeptide, particularly in the prevention, and detection of influenza.