公开(公告)号：US10232020B2

公开(公告)日：2019-03-19

申请号：US15513748

申请日：2015-09-23

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. Dimarchi ,  John P. Mayer ,  David L. Smiley ,  Fa Liu

IPC: A61K38/28 ,  A61K38/22 ,  A61K47/48 ,  C07K14/575 ,  C07K14/605 ,  C07K14/62 ,  A61K47/64 ,  A61K38/00 ,  A61K9/00 ,  A61K47/02 ,  C07K2/00

Abstract: Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.