公开(公告)号：US10232020B2

公开(公告)日：2019-03-19

申请号：US15513748

申请日：2015-09-23

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. Dimarchi ,  John P. Mayer ,  David L. Smiley ,  Fa Liu

IPC: A61K38/28 ,  A61K38/22 ,  A61K47/48 ,  C07K14/575 ,  C07K14/605 ,  C07K14/62 ,  A61K47/64 ,  A61K38/00 ,  A61K9/00 ,  A61K47/02 ,  C07K2/00

Abstract: Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.

公开(公告)号：US10385107B2

公开(公告)日：2019-08-20

申请号：US15513762

申请日：2015-09-23

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. Dimarchi ,  Binbin Kou ,  Fa Zhang ,  John P. Mayer

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/54 ,  A61K47/69 ,  A61K38/00 ,  A61K47/00

Abstract: Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

公开(公告)号：US10683334B2

公开(公告)日：2020-06-16

申请号：US16098236

申请日：2017-05-31

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. Dimarchi ,  John P. Mayer ,  Piotr Mroz

IPC: A61K38/26 ,  C07K14/605 ,  A61K38/28 ,  A61P3/10

Abstract: Modified glucagon peptides are disclosed having improved solubility and/or stability while retaining glucagon agonist activity. The glucagon peptides have been modified by the substitution of pyridyl-alanine for a native amino acid at one or more of positions 6, 10 or 13 and/or substitution with an amino acid in the D-conformation at position 20 or 21 compared to native glucagon.