公开(公告)号：US10385107B2

公开(公告)日：2019-08-20

申请号：US15513762

申请日：2015-09-23

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. Dimarchi ,  Binbin Kou ,  Fa Zhang ,  John P. Mayer

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/54 ,  A61K47/69 ,  A61K38/00 ,  A61K47/00

Abstract: Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.